Lab Efficiency News

Greetings, Lab Enthusiasts!

Countless diseases, especially cancer, affect individuals differently. A one-drug-fits-all approach isn’t practical for treating or fighting these diseases effectively.

That’s where you come in. Understanding both the molecular and functional aspects of an individual is key to optimizing treatment. Our advanced technologies can help you unlock the full potential of precision medicine. In this issue we will cover:

? Spotlight on Precision Medicine solutions

? Revealing genomic profiles

? Best practices: remove PCR bias from NGS workflow

? Cell health analysis: flow cytometry cocktail prep made easier

? Experience before you buy: request a demo or join a webinar

A path to precision

Besides learning about how Revvity can help you get the clarity you need in your research to identify the right target, you will get access to case studies, app notes, a webinar, and more.

• Jensen Lab at the Translational Genomics Institute (TGen) on the use cell-free biomarkers to improve their understanding of neurodegenerative diseases.
• Institute for Molecular Medicine Finland (FIMM) , HiLIFE, and University of Helsinki on functional screening of 3D patient derived cancer cells.
• Centre for Brain Research at the University of Auckland on a multidisciplinary approach in defining early biomarkers of dementia.
• Ronald Germain’s laboratory at the US National Institutes of Health on open microscopy for the high-content multiplex imaging of diverse tissues.

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Revealing genomic profiles?

NGS help researchers discover single nucleotide polymorphisms (SNPs), insertions, deletions, and structural variations. Identification of genetic variations is crucial to allow tailoring research to specific gene makeup. From extraction to analysis, Revvity offers solutions to support NGS research.

Explore now

Biomarkers: remove PCR bias from NGS workflow

Now you can remove bias introduced during PCR with a complete workflow that enzymatically fragments, prepares, and normalizes libraries.

The NEXTFLEX? Rapid XP DNA-Seq Kit v2 is an enzymatic fragmentation-based DNA sequencing solution which produces consistent results without requiring the traditional normalization steps by using NEXTFLEX? Normalization Beads (included in the kit).

Learn more in the app note.

The protocol is completely automated from library prep to normalization pooling on the Fontus?, Sciclone?, and Zephyr? workstations.

Review the results

Cell health and pathway analysis

Functional assays allow researchers to monitor key cellular processes such as apoptosis, proliferation, and immune status – critical for evaluating therapeutic efficacy. Determining cell health through functional drug testing can be assessed in multiple models, one of them being flow cytometry.

Preparing the antibody cocktail accurately is crucial for determining the quality of the collected data. The Fontus flow cytometry cocktail prep workstation can improve precision, standardization, and enhanced productivity.

Learn More

November's top 3 resources

FlexDrop? Plus: another powerful tool for your flow cytometry workflow

This study explores how the use of an automated antibody dispensing system can improve efficiency and data quality by precisely dispensing the colored (fluorophore-conjugated) antibodies and allowing for more control samples.

Check it out

Precision oncology: cfDNA from liquid biopsies

“We use cfDNA extracted with chemagic? technology in digital droplet PCR (ddPCR) assays to support research of colorectal cancer, lung cancer, and anal cancer (based on HPV cfDNA detection) with a sample to result turnaround time down to 24 hours.”

- Professor Niels Pallisgaard, Dept of Pathology, Zealand University Hospital, Denmark

Read the publication

Cell free DNA analysis: end-to-end workflow from plasma

cfDNA is an attractive substrate as it is amenable for inexpensive noninvasive testing and serial sampling. However, it also presents technical challenges such as low concentrations and high levels of fragmentation.

Reliable automated solutions for plasma isolation, cfDNA extraction and processing are critical for sensitive downstream applications such as next generation sequencing (NGS).

Check the app note results

Event news

Dec. 5th: Live researchers’ experience

Emanuele Alves, PhD and D. Joshua Cohen, MD, Virginia Commonwealth University (VCU) on the development of a method metabolite analysis. Benchmark your workflow efficiency for tough sample processing against their work.

Register here.

Or contact your local representative to discuss your specific lab workflow needs and to schedule a demo online or in-person.

Contact us for more info.

We are Revvity, a visionary partner in developing technologies and solutions across disease pathways to help solve the world’s greatest health challenges.

Stay updated on Revvity’s news by visiting our evolving website revvity.com, subscribing to our newsroom, and following us on our new social channels.