L-5-Methyltetrahydrofolate: A Superior Alternative to Synthetic Folic Acid

What is L-5-Methyltetrahydrofolate?

L-5-Methyltetrahydrofolate (L-5-MTHF) represents a form of reduced folate that is a metabolic product of synthetic folic acid in the human body. This includes both L-5-MTHF and dietary folate. It is not derived from natural extracts, and its synthesis avoids the use of harmful solvents and does not produce potentially harmful impurities.

Why use L-5-Methyltetrahydrofolate instead of synthetic folic acid?

1. Direct Absorption without Metabolism: L-5-MTHF can be directly absorbed by the body without the need for metabolic conversion.
2. Effective for Individuals with MTHFR Gene Mutations: MTHFR gene defects can affect the metabolism of synthetic folic acid, whereas active folate like L-5-MTHF is effective for these individuals.
3. Safer Source of Folate: High doses of synthetic folic acid (≥200mcg) can lead to the accumulation of unmetabolized folic acid, which may inhibit DHFR and reduce the body's ability to metabolize natural dietary folate, disrupting normal folate metabolism. The potential harmful effects of unmetabolized synthetic folic acid can take up to 20 years to manifest, while active folate can correct these issues.

Four Major Advantages of L-5-Methyltetrahydrofolate over Folic Acid:

1. Twice the Bioavailability: L-5-MTHF has higher bioavailability compared to folic acid.
2. Direct Absorption without Metabolic Conversion: It can be absorbed directly by the body.
3. Suitable for All Populations: This includes 70% of people who cannot convert folic acid due to genetic metabolic disorders.
4. Safer: It does not produce unmetabolized folic acid.

Advantages of VEGA's L-5-Methyltetrahydrofolate:

1. Stability: It has the longest shelf life, stable at room temperature for two years.
2. High Purity: With a purity level of over 99% and effective folic acid content over 90%.
3. Minimal Impurities: Special techniques are used to minimize all potential harmful impurities and avoid the use of highly toxic raw materials such as formaldehyde during production.

Applications:

1. Theoretical Scientific Perspective:

• Protects red blood cells and prevents megaloblastic anemia, reducing the risk of neural tube defects in newborns.
• Controls homocysteine levels in the blood, preventing cardiovascular diseases, stroke, and hypertension; balances neurotransmitter levels to combat depression and aid sleep; maintains the immune system and improves physical condition.

2. Market Applications:

• Maternal and Infant: Folic acid supplements for pregnant women, cognitive-enhancing children's food, infant formula (Europe), regular food (Europe and the US), maternal milk powder.
• Cardiovascular: Products to lower homocysteine and protect the cardiovascular system, dietary supplements for H-type hypertension, preventive products, adult milk powder (middle-aged and elderly).
• Anti-Depression: Medical food in the US.
• Sports Nutrition Supplements.
• Pharmaceuticals.

L-5-Methyltetrahydrofolate provides a versatile and effective form of folate suitable for various health applications, with significant advantages over traditional synthetic folic acid.

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https://www.vegapharma.com/

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