?? Investing in the Future of Health: Insights from Sergey Jakimov & LongeVC ??

?? Welcome to Your Weekly Dose of The Microdose Diet Inspiration

Where health meets success! I’m Peggy Van de Plassche, and after two decades in finance and tech, I’ve redefined personal and professional growth through health and mental health optimization.

? Prevention, promotion, personalization, and natural solutions are my first lines of defense for staying healthy, happy—and yes, even wealthy. ??

As individuals and companies, stronger health means greater success. As members of society, we have the power to shape a healthcare system that prioritizes prevention, promotes well-being, and embraces natural, personalized solutions.

This is the conversation we’re having on The Microdose Diet podcast: health as the foundation of success + the future of health.

Let’s explore the tools and strategies to help you thrive while shaping the future of wellness. ??

This week, we dive deep into the fascinating world of longevity and biotech with Sergey Jakimov, co-founder and partner at LongeVC. Sergey is a visionary in the VC landscape, focusing on disruptive startups that redefine health and extend human lifespan. His thoughtful, pragmatic approach to longevity and aging provides invaluable insights for investors, innovators, and anyone curious about the future of health.

Here are the key takeaways from our thought-provoking conversation.

??Longevity: More Than Just Lifespan

Sergey started by distinguishing between lifespan—how long we live—and healthspan—how well we live those years. He emphasized that merely living longer isn’t a meaningful goal unless those extra years are healthy and fulfilling. Healthspan, according to Sergey, is the true measure of success in longevity research and investment.

As Sergey eloquently put it, “Why live a long life if it’s not a life worth living?” At LongeVC, this philosophy shapes every investment decision. Their focus is on disease-modifying treatments that improve quality of life while targeting age-related conditions like cancer, neurodegenerative diseases, and cardiovascular ailments.

??A Pragmatic Approach to Aging

Sergey highlighted an ideological divide in the longevity field:

1. Holistic Aging Treatment: Viewing aging as a root cause and addressing it systemically.
2. Disease-by-Disease Focus: Tackling aging through individual conditions that arise as we grow older.

LongeVC belongs to the second camp. By focusing on specific diseases, they ensure investments have clear entry points, measurable outcomes, and realistic exit opportunities. This approach isn’t just practical; it’s essential for aligning with the timelines and goals of venture capital.

Sergey shared that big pharma’s acquisition strategies are driven by concrete results in disease-specific indications. Longevity startups must deliver actionable, disease-modifying innovations to succeed in this competitive landscape.

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??The Investment Thesis: Building Blocks for Longevity

LongeVC’s investments focus on three key verticals:

1. Therapeutics for Age-Related Diseases: Developing disease-modifying drugs for conditions like Alzheimer’s, Parkinson’s, and cancer.
2. Diagnostics: Supporting groundbreaking diagnostic tools, such as a blood-based ovarian cancer detection test, that address critical unmet needs.
3. Drug Discovery Platforms: Investing in enabling technologies, like AI for drug discovery, that accelerate the development of new treatments.

Sergey underscored the importance of disease-modifying therapies over symptomatic treatments. These therapies not only address specific conditions but also offer insights into the underlying mechanisms of aging, potentially paving the way for future breakthroughs.

??Longevity Meets Venture Capital: Balancing Vision and Pragmatism

As a venture capitalist, Sergey emphasized the balance between long-term vision and short-term pragmatism. While the ultimate goal is to better understand and treat aging, investments must deliver tangible results within realistic timelines. Sergey explained that successful exits, often through acquisitions by big pharma, depend on disease-specific assets with proven clinical results.

This pragmatic mindset doesn’t diminish the broader vision of longevity. Instead, it lays the groundwork for sustainable progress by funding research that yields both immediate and long-term benefits.

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??Emerging Trends: Longevity Drugs and AI-Driven Innovation

Looking ahead, Sergey sees longevity dividend drugs—treatments that positively impact multiple diseases—as the next blockbuster category. These drugs have the potential to redefine healthcare by addressing systemic aging processes while delivering disease-specific benefits.

AI is another game-changer. Sergey highlighted its role in accelerating drug discovery, with companies like Insilico Medicine already achieving significant milestones. Innovations in AI-designed molecules and single-molecule protein sequencing are paving the way for faster, more efficient drug development.

??Collaborative Efforts: The Ecosystem of Longevity

Sergey emphasized that progress in longevity is a collective effort involving research groups, startups, VCs, and big pharma. Each plays a unique role in advancing the field. For LongeVC, collaboration is key—whether it’s partnering with researchers to validate hypotheses or supporting early-stage startups through their Longevity Science Foundation.

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??The Big Questions: Lifespan vs. Healthspan

As we wrapped up, Sergey left us with a thought-provoking question: What’s the bigger achievement—living to 100 with a high quality of life or reaching 120 with decades of poor health? For LongeVC, the answer is clear: prioritizing healthspan leads to a life worth living, and as a byproduct, it may naturally extend lifespan.

??Final Thoughts and What’s Next

Our conversation with Sergey Jakimov was a masterclass in blending vision with pragmatism. His insights into longevity, aging, and the VC mindset challenge us to think differently about what it means to invest in health. Sergey’s focus on healthspan, disease-modifying therapies, and innovative platforms offers a roadmap for sustainable, impactful progress in the longevity space.

Stay tuned for more episodes of The Microdose Diet Podcast, where we explore transformative ideas at the intersection of health, wellness, and innovation.

??Transforming Health and Success: Meet Peggy Van de Plassche ??

I’m Peggy Van de Plassche, a former banker and venture capitalist with 20 years of experience in financial services, technology, and public service. Today, I leverage my expertise in navigating innovation, highly regulated environments, and large-scale transformation to bring fresh solutions to the healthcare space.

I focus on two core areas: 1?? Advising Large Organizations: I work with companies and public service entities to navigate the tectonic shifts in healthcare, driving systemic improvements through innovation, technology, and strategic insights. 2?? Empowering Individuals and Companies: I help leaders, professionals, and teams achieve greater success by strengthening their physical and mental health. This means calming the body, rewiring the brain, mastering emotions, and raising energy to unlock their full potential.

How I Can Help You

?? Order My Book: MORE! The Microdose Diet, The 90-Day Plan for More Success, Passion, and Happiness—a comprehensive guide to personal transformation. Available on Amazon and Indigo.

?? Work With Me:

• For Organizations: Let’s strategize on healthcare system improvements, from leveraging technology to embracing patient-centric models.
• For Individuals and Teams: My 90-day coaching programs (one-on-one or group) focus on achieving optimal mental and physical health for sustained success.

?? Keynotes and Workshops: Bring actionable insights to your organization with “Microdosing for Personal and Professional Development” or customized workshops on health-driven performance.

?? Try Brain Power Microdose: Enhance cognitive function, reduce stress, and elevate creativity with this science-backed supplement.

?? Explore My Online Course: The Microdose Diet: The 90-Day Plan for More Career Success, Passion, and Happiness is a proven system to transform your health and career trajectory.

A Trusted Voice in Health and Wellness Innovation

My work bridges the worlds of healthcare reform and individual wellness. With two decades of experience in technology and public service, I offer a unique perspective to help organizations navigate seismic changes in healthcare while empowering individuals to thrive in their personal and professional lives.

I believe true success begins with a foundation of strong mental and physical health. Whether through advising large organizations or guiding individuals, my approach focuses on creating tangible, lasting impact.

Let’s Work Together

?? Whether you’re a leader in the healthcare space looking for strategic advice or an individual seeking personal growth, I’d love to help.

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Disclaimer: This newsletter is for inspiration and information. Always consult a medical professional for health-related decisions.

Here’s to reshaping health, redefining success, and building a better future.

Peggy ??