Influence of a redox-signaling supplement on biomarkers of physiological stress in athletes: a metabolomics approach

The purpose of this edition of Enter Redox - Health Longevity is to make the advanced science of redox signaling accessible and applicable to everyday health. Today, we review a breakthrough study conducted by the Human Performance Laboratory, which investigates ASEA’s redox signaling supplement and its remarkable effects on athletic performance and recovery through a process known as metabolomics. This research explores how ASEA’s unique approach to redox signaling influences the body’s natural rhythms, supporting resilience, energy efficiency, and cellular harmony.

Our goal is to translate these scientific findings into practical insights, showing how redox signaling can optimize metabolic function, assist with recovery, and prepare the body for physical challenges. As we unpack these findings, we’ll uncover how redox molecules help sustain energy, cellular communication, and balance, underscoring their role in maintaining health at the cellular level.

Let’s explore a 2012 peer-reviewed study published in the Federation of American Societies for Experimental Biology (FASEB) on ASEA’s Redox Signaling supplement and discover how it’s paving the way for enhanced health and longevity.

The North Carolina Research Campus Human Performance Laboratory: A Hub of Trust and Excellence

This institution of science is where sports and health converge to explore human resilience and peak performance. This is the North Carolina Research Campus Human Performance Laboratory, led by Dr. David Nieman, a figure deeply respected in the field of exercise and nutrition science. Dr. Nieman’s journey in health research spans decades, during which he has become a pioneer in exercise and nutrition immunology. His work has not only influenced how athletes prepare and recover but also opened new doors in immune health and stress resilience.

With over $10.9 million in research grants and more than 370 peer-reviewed publications, Dr. Nieman and his team embody expertise in sports science. Known for his meticulous approach using cutting-edge methods to examine how unique products like ASEA affect the body. This research lab—is a place where breakthroughs happen, supported by a leader who genuinely cares about improving people’s health.

Under Dr. Nieman’s guidance, the lab’s mission focuses on helping people—from top-tier athletes to everyday health-conscious individuals—overcome physical strain, reduce inflammation, and maintain a robust immune system. The team’s work has touched the lives of thousands, creating a ripple effect across the wellness world. With Dr. Nieman at the helm, the lab exemplifies a commitment to discovery and innovation, aiming to support everyone in their pursuit of healthier, stronger lives.

What Are Metabolites and Why Do They Matter?

Metabolites are small molecules produced during the breakdown of food and energy sources in the body. Think of them as the "byproducts" of metabolism, like the leftover crumbs after you’ve eaten a meal. They tell a story about how your body is processing nutrients and whether it's operating optimally. In a healthy metabolism, metabolites act as the body’s messengers, signaling how efficiently the body is converting nutrients into energy.

Healthy metabolism relies on these small molecules to maintain a rhythm. When our metabolites are balanced, we feel energetic, focused, and resilient to physical and mental stress. Imbalances, however, can throw off this harmony, leading to fatigue, slower recovery, and weakened immunity. ASEA’s support for these metabolic messengers helps maintain this natural harmony, tuning up the body like an engine for peak performance. This study examined ASEA’s impact on these crucial players in the metabolic process, unlocking how ASEA could help support a smooth and efficient metabolic function, just like tuning up an engine for peak performance.

What is Redox Signaling and ASEA’s Role?

Redox signaling is a complex yet crucial process that happens at the cellular level in your body. Imagine a network of tiny walkie-talkies inside your cells, sending signals back and forth to maintain balance and repair damage. That’s redox signaling in action—ensuring that cells communicate and function at their best. These signals regulate everything from immune function to inflammation, and even the body's ability to repair itself.

Over the last 27 years, the field of redox signaling has exploded globally as scientists discover more about how cells maintain health and resist damage from oxidative stress. ASEA’s redox signaling supplement taps into this communication process, providing the body with stable redox signaling molecules that can support cellular health. Think of it as upgrading your cellular walkie-talkies to the latest model, helping them transmit messages more clearly and efficiently.

This is where ASEA stands out. It’s not a nutritional supplement—it's a cutting-edge technology designed to restore the body’s innate ability to heal, restore balance, support cellular detox, and open pathways to vitality. By doing so, it helps the body handle stress, inflammation, and the ongoing wear and tear of daily life at a fundamental level, promoting holistic health. ASEA enhances the body’s natural balance by helping cells communicate more effectively, supporting resilience and well-being at the cellular level.

The Study’s Aim: Impact, Verification and Protocols

The goal was to examine ASEA’s influence on the body’s response to exercise and physiological stress. Researchers used a randomized, double-blind study to compare the metabolite shifts in athletes consuming ASEA to those taking a placebo, expecting that ASEA might affect metabolic markers before or after exercise. This approach to preparing the body for exercise aligns with the goal of supporting health holistically, by naturally strengthening and balancing the body.

Before delving into ASEA’s physiological impact, researchers verified its contents with a Nuclear Magnetic Resonance (NMR) spectroscopy. This examination confirmed that ASEA contains stable redox signaling molecules, specifically reactive molecules like superoxide, which play a crucial role in cellular signaling. The stability of these molecules in liquid form was a breakthrough, allowing researchers to pursue credible publications on ASEA’s effects.

The study involved 20 cyclists split into ASEA and placebo groups over two seven-day cycles, with a crossover after a washout period. Subjects cycled 75 kilometers after each supplementation phase, and researchers drew blood at pre-exercise, post-exercise, and one-hour post-exercise intervals. This setup ensured a clear comparison between ASEA’s and the placebo’s effects on physiological biomarkers.

Groundbreaking Findings: Metabolite Shifts and What They Mean for Everyone

The results from this groundbreaking study were far more profound than anticipated. “It was a large shift that caught us by surprise,” one scientist noted, describing it as a “game-changer” for athletes and non-athletes alike.

Researchers initially expected to see metabolite shifts during or after exercise, as most supplements show their effects when combined with physical effort. However, what they found was astonishing: ASEA caused significant shifts in 43 metabolites representing nearly 40% of all metabolites tested before the athletes even began cycling. This was a huge finding, as typical supplements cause only a few shifts, mostly after exercise. This means ASEA wasn’t just helping athletes during their workouts; it was preparing their bodies ahead of time, setting the stage for better performance, quicker recovery, and enhanced stamina.

What does this mean for athletic performance? For athletes, this could translate to longer training sessions with less fatigue, faster recovery, and less muscle soreness after intense workouts. Essentially, ASEA “primed” the body for better performance, even before the athletes began their workout.

These findings just don't benefit elite athletes. For everyday people, this means that ASEA can support the body in maintaining energy reserves, improving recovery, and even potentially helping manage weight, as the body is more effective at burning fat for fuel. The profound metabolic shifts seen in the study show that ASEA works on a cellular level to prepare the body for anything—from a heavy workout to a busy day of work or family activities. This is a truly holistic benefit, supporting the body’s natural resilience and balanced energy use in a way that reinforces overall well-being.

The Athletes: What Did They Have to Say?

After hearing the study's results, elite athletes who have used ASEA for years shared their thoughts on how the findings matched their personal experiences. Here’s what they had to say:

• Diana MacManus, 3-Time National Swimming Champion: “I’ve seen my training and race times improve significantly. Learning about the research behind ASEA just boosted my confidence. Now, knowing that the science supports what I’ve already experienced makes me even more confident that ASEA helps me swim faster.”
• Shawn Burke, Physical Therapist and Triathlete: “At 51, I’m able to train and compete against 25-year-olds—and beat them time after time. The science behind ASEA has completely blown me away. It’s clear that ASEA is doing something extraordinary for my body, and now it’s been backed by science.”
• Keena Schearrer, Ironman Triathlete: “I’ve already experienced ASEA’s effects in my personal training and performance. So, hearing the study confirms what I’ve felt all along is great! Knowing that it’s backed by research gives me even more confidence in my performance.”
• James Lawrence, Ironman World Record Holder: “I’ve been using ASEA for years, and I’ve always wondered why I didn’t experience the usual post-race soreness. Now that we know from the study that ASEA helps prevent muscle damage and supports endurance, it’s a huge relief. I can maintain my strong pace, recover faster, and keep breaking records.”

These accounts underscore the incredible impact ASEA is having on the athletic community. The study confirmed that ASEA is fueling performance in ways previously not understood.

Key Takeaways: The Power of ASEA for Health and Performance

The study offers compelling insights into how ASEA supports performance, recovery, and daily health. Here are four major takeaways:

• Enhanced Metabolism: ASEA helps mobilize free fatty acids, an essential fuel for the body, which supports longer endurance during exercise and spares muscle glycogen.
• Fast-Acting and Long-Lasting Effects: ASEA’s effects are noticeable within 30 minutes of drinking it, and the impact lasts over 24 hours, providing athletes with sustained energy.
• Supports Recovery and Reduces Soreness: By increasing available fuel and sparing glycogen, ASEA may aid in faster recovery, allowing people to perform at a high level consistently.
• Everyday Benefits Beyond Athletes: While ideal for athletic performance, ASEA also benefits anyone who wants to support efficient energy use, quicker recovery, and a healthier metabolism.

ASEA: A Commitment to Research and Development

ASEA continues to push boundaries through multiple ongoing studies in collaboration with esteemed universities worldwide. This research reflects ASEA’s dedication to advancing the science of redox signaling and uncovering the full scope of its benefits.

As these studies progress, they will further reinforce ASEA’s role as a holistic health ally, offering powerful, natural support for those seeking preventive, wellness-focused solutions. ASEA’s pioneering work in redox signaling is helping to shape a future where enhanced well-being is accessible for people around the globe.

The information in this article offers a small glimpse into ASEA's Redox solution. To explore it further please visit my page at www.redox-mastery.com.

Ricardo Wilkins

Editor: Enter Redox - Health Longevity

ASEA Distributor and Author of, "Life's Biohack: The Health Secrets of Redox Signaling Revealed"

References:

Shanely, R. A., Nieman, D. C., Henson, D. A., Knab, A. M., Cialdella-Kam, L., Meaney, M. P., Baxter, S., & Sha, W. (2012). Influence of a redox-signaling supplement on biomarkers of physiological stress in athletes: A metabolomics approach. The FASEB Journal, 26(1_suppl), lb713. https://doi.org/10.1096/fasebj.26.1_supplement.lb713

Appalachian State University. (n.d.). Human Performance Laboratory. App State North Carolina Research Campus. Retrieved November 10, 2024, from https://ncrc.appstate.edu/human-performance-laboratory

ASEA Metabolic Results