Immunosuppressants: key element in organ transplantation
Inkwood Research
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History has been created with the transplant of a pig heart to the human body in the US. The heart transplanted into Mr. Bennett came from a genetically altered pig by?Revivicor, Inc., a regenerative medicine company in Blacksburg, Virginia.
With 10 genetic modifications, the pig had four genes knocked out or inactivated, including one that encodes a molecule that causes an aggressive human rejection response. This new stream of organ transplantation from animals to humans will save millions of human lives worldwide in the near future.
For any organ transplantation, the key element is to reduce the body’s immune system so that the body doesn’t reject the transplanted organ. For this purpose, immunosuppressant drugs are an important factor.
Immunosuppressants are a class of drugs that suppress or reduce the strength of the body’s immune system. The immune system?helps fight off infections that cause illness. However, it sometimes mistakenly attacks healthy cells and tissues. In this regard, immunosuppressants can slow or stop this response.
Many people require an organ transplant due to a genetic disorder, such as polycystic kidney disease, cystic fibrosis, or a heart condition. Infections like hepatitis, physical organ injury, and damage caused by chronic diseases like diabetes might also necessitate a transplant. During the hyperimmune hyper transplantation procedure, these drugs are frequently employed.
With the help of immunosuppressant drugs, a new field of study in organ transplantation has opened up. Moreover, the course of human organ transplant treatment has also been altered.