Immunity & Inflammation

The primary function of immunity is to recognize and eliminate foreign antigens, thereby protecting the body from harm. Immune responses are protective reactions of the body against pathogens, infectious agents, or tissue damage. Inflammation is a type of immune response that typically occurs during the innate immune phase. Inflammatory stimuli, including infection or tissue damage, can trigger a cascade of cytokines, chemokines, and other proteins, leading to local redness, swelling, heat, and pain in the body.

Chronic inflammation may result in dysregulation of innate immune responses and alterations in the microenvironment of surrounding tissues, thereby reducing the effectiveness of functional immune responses within the body. Many diseases are mediated by chronic inflammation caused by microbial agents, autoimmunity, allergies, metabolic factors, or physical conditions. These diseases include cardiovascular diseases, cancer, diabetes, arthritis, Alzheimer's disease, lung diseases, and autoimmune disorders[1][2][3].

• TargetMol related products

TargetMol, as a one-stop drug screening expert, offers stable and diverse products to meet various research needs. We provide a wide range of inhibitors and agonists targeting different pathways and targets related to immunity and inflammation, along with cytokines, compound libraries, and drug-like compound libraries.

1. Compound Library (part)

L4700 Immunology/Inflammation Compound Library | TargetMol

L4710 Nonsteroidal Anti-Inflammatory Compound Library | TargetMol

L6710 Anti-Inflammatory Traditional Chinese Medicine Compound Library | TargetMol

2. Inhibitors & Agonists (part)

T11855 Lipopolysaccharides Lipopolysaccharides | Inhibitor | TargetMol

T1394 Ibuprofen Ibuprofen | COX | TargetMol

T0005 Aspirin Aspirin | COX | Mitophagy | Virus Protease | Autophagy | TargetMol

T2144 Tacrolimus Tacrolimus | Inhibitor | Phosphatase | Antibacterial | Antibiotic | mTOR | Autophagy | TargetMol

3. Antibody (part)

T6321 Tofacitinib Tofacitinib | Src | JAK | ROCK | Apoptosis | TargetMol

T9910 Rituximab Rituximab | Inhibitor | TargetMol

T9911 Tocilizumab Tocilizumab | Interleukin | TargetMol

T9921 Infliximab Infliximab | TNF | TargetMol

4. Cytokines (part)

TMPY-02788 IL-2 Protein, Mouse, Recombinant IL-2 Protein, Mouse, Recombinant | TargetMol

TMPY-02350 IL-12 Protein, Mouse, Recombinant (His) IL-12 Protein, Mouse, Recombinant (His) | TargetMol

TMPY-03238 IL-6 Protein, Mouse, Recombinant IL-6 Protein, Mouse, Recombinant | TargetMol

TMPY-03356 IFN gamma Protein, Mouse, Recombinant IFN gamma Protein, Mouse, Recombinant | TargetMol

• Customer validation

ATM (Ataxia Telangiectasia Mutated), as a protein kinase, plays a crucial role in the DNA damage response process. In cells with unstable intracellular environments under chronic inflammation, susceptibility to DNA damage is increased. When cells experience DNA damage, it can lead to double-strand breaks, activating ATM to participate in processes such as DNA repair, cell cycle regulation, and apoptosis.

In studying the function of ATM during the DNA damage response, our client chose to visualize the dynamic changes in ATM activity using ATM-SPARK. They utilized TargetMol's Immunology/Inflammation Compound Library (Catalog No. L4700), transfecting cells with an ATM-SPARK expression plasmid, and then conducted a high-throughput screening following the addition of the DNA damaging agent cisplatin. This screening identified a potential compound, BGT226, which modulates ATM activity.

For more products or services, please visit: https://www.targetmol.com/

References

1. Goldberg EL,et al. How Inflammation Blunts Innate Immunity in Aging. Interdiscip Top Gerontol Geriatr. 2020;43:1-17.
2. Hawiger J, et al. Decoding inflammation, its causes, genomic responses, and emerging countermeasures. Scand J Immunol. 2019 Dec;90(6):e12812.
3. Aggarwal BB. Nuclear factor-kappaB: the enemy within. Cancer Cell. 2004 Sep;6(3):203-8.
4. Agirman G, et al. Signaling inflammation across the gut-brain axis. Science. 2021 Nov 26;374(6571):1087-1092.
5. Sun SC. The non-canonical NF-κB pathway in immunity and inflammation. Nat Rev Immunol. 2017 Sep;17(9):545-558.
6. Li X, et al. ATM-SPARK: A GFP phase separation-based activity reporter of ATM. Sci Adv. 2023 Mar;9(9):eade3760.