i3S Inside Stories

i3S Inside Stories

Highlights from June 2024


Breakthrough in Sepsis Treatment: New Biological Therapy Unveiled

Alexandre Carmo and Liliana Oliveira from the Cell Activation and Gene Expression group

A study headed by i3S researchers Liliana Oliveira and Alexandre Carmo has shown that intravenous administration of CD5L, an endogenous anti-inflammatory protein, effectively treats sepsis in experimental models. Published in Nature Communications, these findings highlight CD5L as a potential treatment for human sepsis.

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Mariana Osswald wins L’Oréal Medal of Honour

Mariana Osswald is an i3S researcher and guest assistant professor at ICBAS

How do epithelia respond to pressure, preserving their shape and functions altered in various pathologies such as cancer and inflammatory diseases? With this question, the project presented by researcher Mariana Osswald won one of the four L’Oréal Portugal Medals of Honour for Women in Science, awarded in the 20th year of the initiative.

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Inês Alves wins Exploratory Scholarship from European society

Inês Alves' ultimate goal is to develop a new, less invasive and safer marker for the prognosis and monitoring of Systemic Lupus Erythematosus

Researcher Inês Alves won one of two 2024 Exploratory Research Grants, worth ten thousand euros, awarded by the European Society for Clinical Research (ESCI). The project aims to find biomarkers that improve early diagnosis and clinical and therapeutic monitoring of patients with Systemic Lupus Erythematosus.

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PhD student wins Excellence Award with 2023 article

Lídia Faria is a student in the Doctoral Programme in Molecular and Cellular Biology at U.Porto and is doing research at i3S

Doctoral student Lídia Faria, developing research work at the i3S, won the Award for Excellence for articles from 2023 in the Research category, awarded by the scientific journal Disease Models and Mechanisms. The article was featured on the cover and describes the development of an “avatar” fly to understand how benign breast lesions become cancerous. The findings allow us to identify women who are most at risk of developing breast cancer.

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i3S uncovers the role of the thymus in preventing autoimmune diseases

Nuno Alves and Camila Ribeiro investigated T lymphocytes and how they are trained and educated during their development

A group of i3S scientists, led by researcher Nuno Alves, has just published an article in the journal "Cell Death and Disease" explaining what fails in the production of T lymphocytes as we age and what triggers the development of autoimmune diseases. This discovery paves the way for therapeutic solutions to counteract the ageing of the thymus, support the elimination of T lymphocytes that can cause autoimmune diseases and strengthen the immune response.

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Lupus project awarded Internal Medicine Award

Daniel Guimar?es de Oliveira combines his experience as a specialist in Internal Medicine at the Tamega e Sousa Local Health Unit with his research at i3S.

The team part of the SLE-CORIOLIS project, led by Daniel Guimar?es de Oliveira, clinician and researcher at i3S and ICBAS, recently won the Research Grant in Internal Medicine (EIMI Award). The award was presented at the 30th National Congress / 9th Iberian Congress of Clinical Medicine and researchers will now have the opportunity to explore the factors that determine the health-related quality of life of patients with Systemic Lupus Erythematosus.

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