I Write This With Paradigm Shift in Mind

I Write This With Paradigm Shift in Mind

 I have updated the best way to compare and control the color codes representing each of the nucleotide families in the 7 Heptad Genomic Code we are pushing for. i.e. Inosine and Xanthosine purine nucleotides operate mostly in the small RNA molecular, epigenetic gene control level, a layer for a SNP to symmetry operators for multiple miRNa,shRNA, siRNa, PiRNA,RNAi, crcRNA and the ALU transposon domain, this SINE short inter- dispersed Nucleotide Enzymes. mRNA editing at least 90% of all mRNA transcripts generated from the DNA template strand. At some point through the complex synthesis and degradation processes, these 90+% DNA instructions need to be changed because too much non-random variance has occurred and the ADAR 1,2,3, Ribozymele , particularly the Adenosine to Inosine editing and alternative slicing making new transcripts, primarily in the higher levels of the neocortical brain. mRNA editing with short miRNA scripts guide the appropiate genomic message to the deamination biomachinery starts opening up the Toxic NH3 ion channels of glutamate AMPA and NMDA receptors, stimulating the serotonin 5HT Trptophan precursor. This glutamate must be edited or the new born infant will die. If this "kill switch" is encoded in the DNA/RNA/Epigenetic neural circuitry it must be total conserved across mammalian species and it is. Inosine family gets rid of toxic NH3 through hypoxanthine, and xanthine oxidase which is the final step in purine nucleotide metabolism.

 

Visioneering ProAfter you read this message from a Genomic Scientist, me, please review the

450+ blogs about the true story of my search and research I have spent the past 15+ years dedicated to this scientific investigation, analysis, conclusions, feedback, none;  signal = nothing negative or incorrect, don't see such as big deal, what does it matter if you use 7 instead of 5 in your daily calculations. Nature is much, much, much, more precise than human cognitive mathematical calculations, use for manipulating whole numbers, the difference from the frame of reference of the visual inside your minds eye is really out your eyes and vice versa; the human race has been fooled and manipulated by 4th dimensional beings who are invisible due to being dark matter. The scale of measurement for the average citizen is pennies, nickels, dimes, quarters, dollars, thousand if lucky ten thousand dollars.  60 years ago genetic and epigentic codes or ciphers did not have the  safeguards in place so that a disaster of such magnitude could not have occurred because the power  and force of nature  could be controlled by mass extinction.

7 & 5 =  28% probability of occurrences of numbers 6 or 7 in a 5 coded message, sounds tricky, and of course it is! In fact, it is impossible, and that is one giant obstacle in my proving nature's true evolutionary code is 7 not 5.  

 Don't you think mother nature in 3.5 billion years would find endless uses for Inosine and Xanthosine because they carry as a functional side group, the oxo ion or Inosine =O1-, or Xanthosine = O2. Every where from cosmic dust, to comets which carry both adenine and guanine, but at the same time hypoxanthine, and xanthine. In one study only uracil, and xanthosine was found.

Never the less there is an odd connection between comet based nucleotides and  their associated codon/anti-codon covalent hydrogen bonding  and the same amino acids that inosine encodes and decodes the RNA genomic code of 7-8 wobble amino acids (leucine, isoleucine, alanine, serine, threonine, proline, and arginine. These 7 amino acids are frequently found in meteors, comets, asteroids and other smaller celestial bodies which burn up in our atmosphere and crash into the oceans.

Most of the basic building blocks of the human body comes from places and things we know nothing about. You cannot know anything if that subject matter is unknowable on three or four dimensions, but perhaps manifest itself only in 7 dimensional space in dark space where our brain tissues and limited craniums are the constricting factors, for evolutionary growth.

I make the arguement that Sir Francis Crick, brilliant man which he was, made one hypothetical speculation which unfortunately for us, has the potential to undermine the entire genomics infrastructure .

There should have been 7 nucleotide genetic codes from the beginning of designing and synthesizing product codes which are missing 2 digits; what do you think the odds are, if you put only 3 and not 5 numbers as your zip code address. Do you think your letter would get to its proper location with only a 3 digit zip code, when the standard is 5, mine is 60540.  If you want to wire me money make sure the zip code has 5 digits.  We have a hearty laugh, but at whose expense.  Us, the USA taxpayer, and all sectors of the world economy which intersect genetics, medicine, information, analysis and empirical recommendations. 

All our current genomic infrastructure is based on the 5 Watson-Crick genetic codes as we stated above; what if the 7 nucleotide genomic code explains many of the SNPs, many diseases caused by deamination, and progenitors of the RNAP II Ribozyme, the first self-replicating sequence species to have it's head bite his or her tail and fusing together, to form a closed circuit of purine and pyrimidine nucleotides. 

Dr. Crick and the " 20 RNA Tie Club members"i.e. finalized the current genetic codes in 1966.  The Watson-Crick central dogma theory genetic code = dna = ATGC, rna=AUGC.

My overarching question is why were inosine and xanthosine not made part of the original code. They have hundreds and thousands of shared metabolic networks within purine metabolism. The major reason I believe is their sequencing technologies did not allow deep enough sequencing, scanning one or two versus 50 to 100 times for each nucleotide uncovers the most deeply rooted conserved sequences for unicellular organisms. 

More importantly, small RNA molecules, the operational part of the genetic material or RNA single and two stranded RNA is where evolution took a giant leap, especially in brain tissue, glutamate and serotonin neurotransmitters as well as thicker, longer and stronger fiber optic channels for biomolecular calculating. 

This ADAR 1 Adenosine to Inosine deamination which occurs is all organic molecules which contain nitrogen. It is a very popular duo carbon and nitrogen.

The fact they are atomic neighbors C6 and N7 explains the C4N2 closed hexagonal 6 sided aromatic molecular structure just happens to exactly make up a large volume of the purine and pyrimidine base atomic mass units. 

We strongly more than ever, believe the genetic code was not frozen and that  The Inosine = I, X = Xanthosine purine nucleotide families belong right aside their purine neighbors, Mr. Red =Adenosine family and Mr. Green = Guanosine family: To enable DNA replication, RNA transcription &  Protein Translation.

Mr. Orange (Inosine), and Mr. Indigo (Xanthosine) play key, critical roles, in purine and pyrimidine metabolism , they are necessary for growth and surivial  as well  at finding way to more effectively rid our fellow tissues and cells of toxic NH3) when it becomes NH-- when the larger Oxygen atomic molecule captures Nitrogen's 2 hydrogen atoms = 1 hydrogen molecule,  and wants to bond to make water. That is biochemical rule 101. Monitor and maintain water and minerals which are fine tuned to your ionic frequency. 

There is no need to synthetically bioengineer new, foreign nucleotides/Oligonucleoties , when two natural, and just waiting to be moved from the MINOR to the MAJOR Purine Nucleotide Family (IMP,XMP) where they can join their coworkers and internucleotide cooperation in every enzyme catalyzed biomolecular reaction , to work as a team, whose tremendous burden to carry and be the physical embodiment of the "genetic material" in the form of 3 component structure, original build by a sugar (ribose) glycosidically bonded with a phosphate (PO3-) substrate and were joined to the first closed purine aromatic, heterocyclic molecular structure which nature chose to encode and decode the genetic material of life in the form of DNA and RNA nucleic acids.

Now I Give you the Sixth and Seventh Genomic Ciphers along with the Rosetta Stone for Scientific English translated with words and ideas which contain I, like I = Inosine, me, self identity, individual, initiate, terminate, addition, subtraction, genetic loci, chromatid genetic strings, vibrating and reasonating in brain tissue with sine and cosine polarity enriched within nuclei atomic rings photosynthetic spherical hamiltonian circuits, hidden genetic material existing in different spatial coordinates. 

Visioneering Rapping Texting using I i - critical cognitive mapping using I lettered words; if it contains within its identity domain. I = beginning, ending, life. It is critically important maximal idea independence, which symbolic logic is included in geometric/algorithmic computation. 

The letter I = Inosine is the key translation symbol between the physical three dimensional world of genomics and scientific intelligence. Without exception I or i is a critical defining translational cipher in scientific english and scientific symbolic representation. Everything begins and terminates with this ironic icon which is  silent and hidden in the voice and hearing devices using sensing technologies in measuring, identifying, mapping and discovering right solutions.

?Scientific audience reading this interesting innovative scientific visioneering production. It will excite visual, right brain, inner visions with mind/brain filtering, sorting, searching, discovering, ideas which impossibly shift direction in Scientific Genomics with addition in additional purine nucleotides, nucleic acids, amino acids, proteins, chromatid loci, encoding decoding genetic material geometric algorithms which involve mathematics, bioinformatics, medical clinical diseases disorders metabolic flowing ions oxidation-reduction biochemical/biological conjugation, mitosis and meiosis. Evolution atomic composite, tissue, brain biomagnetic hamiltonian dendritic and synaptic signaling with organic, flexible fibers which switch photonic warning signs, signals, communications.

Scientific Investigation into genomics, find empirical, experimental, written, validated insightful analytical statistical solutions with algorithms, positions, functions, locations, identification atomic periodic families, electronic orbitals, magnetic polarity particle spin, rotational, twisting, spinning, inverted, palindromic, purine & pyrimidine nucleotide, nucleoside pairings, genetic nucleic acids & proteinous amino acids, polypeptide binding inter protein connections, bridges, ionic bindings, oxidation/reduction biomedical & bioinformatic information and evolutionary conservation of traits, functions,  genetic loci, mapping single nucleotide polymorphic mutations; ribonucleic acid/protein catalysis, editing, alternative splicing, brain tissue, deamination toxic ammonia, neurotransmitters, biochemical metabolic initiating, replication, transcription, translation, protein manifold toroidal properties & topographical mapping and identifying information strings which contain compression algorithms, to resize atomic & nucleic acid in Felix Kleins Quartic platonic solids including sixth tiling of heptameric trignometric ratios of sine/cosine calculations for spherical equations triangulated against protonic light reflection, diffraction, mirror image & pigment absorption.Biology, organic & inorganic chemistry, physical, biochemical atomic properties unique differentiator & identities.

Updating corrections and mistakes Watson-Crick canonical five nucleotide genetic primer ATGCU; expanding new version with addition of Inosine and Xanthosine purine nucleotide families and anti-codon miRNA final transcripts.
Coevolutionary nucleotide/amino acid direct mapping mitotic & meiotic germline expression of reproduction timing & developing/dividing instructions nutritional ingredients, organic residues, guiding micro skeletal fibers and troponin activated heptameric filtering and screening, potential toxic antigens so immune anti-bodies can neutralize and eliminate organisms, bacterial infections, viral intrusions, fungi & parasitic uni and multi symbiotic entities increasing fitness and flexibility of geometric crystalline lattices of atomic blueprints and architecture of spatial coordinates on universal grids of gravitational and electromagnetic fields with provide protection against excessive radiation of ultraviolet light or microwave vibrations.
This scientific storyline is non-linear, non-Euclidean curvilinear spherical genetic loci which transmit meaningful signals directly inscribed within the circumference of the prescribed hamiltonian circuit to optimize signal to noise ratio, increasing probability of faithful decoding and encoding of genetic material inherited from generation to generation of specific species.

12 total organic compounds for possible organic compounds. Guess how many of these 12 , have oxygen’s as part of their functional group?

What number have we consistently praised as the magic number in all bio-molecular organic chemistry. 

How about you dear reader, guess how many have the ability to make water, which itself, makes up about 70% of a human beings body mass.

H2O is the most valuable molecule on earth, and look how we treat it. Take it for granted. 

If you guessed SEVEN of the 12 have the right atomic elements to make water you would be right. Quite a big,big,big, DEAL in my mind. 7 has proven example after example to be the organizing part/whole self contained unit to inititate, sustain, maintain, repair & replicate genetic material, unit of inheritance, fitness and adaptability

 Disclaimer: I universal scientist , empirical evidence is direction which benefits all living organisms which utilize universal genetic epigenetic heptameric genomic cipher. Validation ,Reliability, Replicable scientific design with standardized annotations. Mission, objective, life is finish this validation comparison 5 vs. 7 nucleotide genomic primer. 

This following information is subjective, scientist live outside America, intended give positive criticism equalizing influence, decisions, international community, rightly wishes their input into international scientific affairs and experimental collaboration; intelligence available with public consumption.

To make a long story, shorter: Americans, are known for their arrogance, and an unfounded attitude, that they are the smartest people on earth and they should control most if not all of the world's intellectual property as well as all currencies based on the dollar.

Not at all Open minded as to the possibility the 5 code genetic code should have 7 codes instead. Maybe the genetic code was never frozen but remained undetected in regions labeled "viral graveyards" and moved on to working on Proteins.

As we now know  only 3-5% of the 3.2 billion nucleotide base pair sequences are dedicated to protein metabolism. It is in the 97% of the human genome which has recently been deeply sequenced in non protein coding introns with long and short untranslated 5' & 3' RNA transcripts which is the next great frontier of Genomics. 

 This thesis of mine, has been tested and validated everytime I try to convince a genomic scientist, University Professor, Federal Lab expert, University lab team project leader.

Nobody in America is ready to consider the possibility of Crick's frozen theory of the genetic code could be wrong.

I am discouraged that the majority of my American Life Science Colleagues have such a closed mind, focusing on strategies for maximizing short term opportunities, even if  what is being promoted has not been 100% validated. Winsorize all sequences three deviations from the target mean. Insidious degradation is destroying  homo sapiens genetic matieral by inheriting mutated germline totipotent stem cells, splicing valid part/whole components, degrading crucial signs signals; instructions ignored, frameshift pausing, timing, synchronizing, operational principles with evolutionary universal motifs, imprinted circuits in synaptic biochemical, biological, photoelectric interfaces within communication signaling distance.

I am apparently not the only scientist on earth with some doubts about the validity of the 5 Nucleotide DNA =ATGC, RNA = AUGC = ATGCU genetic codes; many English, German, and French scientists are stakeholders in the 5 nucleotide genetic code and the billion of dollars invested in the Watson Crick DNA and RNA 5 genetic codes.

They are obviously threatened and afraid of sixty year old scientific and technological infrastructure being wrong; creating more diseases than they are curing, rejuvenating or even extending a complex disease patient ie. cancer, heart disease etc.

Their fear is well founded, if you view the PDR, the 10,000 prescription drugs analyzed have never reported a synthetic man made therapeutic molecule i.e prescription drug, which has been synthesized without two or more toxic side effects, with many having 10 or more unintended negative consequences. Prescription drugs directly kill over 100,000 people each year and hospitalize at least 2 million more.

This adds weight to the lack of validity of the current 5 code genetic code.
While some synthetic biologist have tried to bio-engineer oligonucleotides or nucleotide base pairs, only one has successfully gotten past the DNA Replication phase which is only the opposite complement strand being cloned. The genetic message never leaves the nucleus for mRNA transcription because the heptameric nuclear pore filters and degrades these transcripts back into the nucleotide pool.

The 5 code genetic code has never been formally validated, it became the default winner when Dr. Lineus Pauling, one of my heroes and winner of two different nobel prizes, made some minor miscalculations based on poor, cloudy x-ray diffraction images  guessing at the angstrom level which way the sugar-phosphate backbones pointed in DNA.  Pauling guessed inward which was too small in  volume to acommodate the purine base pairs. Since Paulings model was wrong, Watson-Crick's logically must be right. This is the fundamental inductive logic and rationale for the current 5 nucleotide genetic code which has never been updated or revised for over its lifetime of 60+ years.

Inosine is the nucleoside representative in Hypoxanthine Family which includes Xanthine Family, cousins in purine metabolic biomolecular reactions defined in universal genomic primer, established with almighty singularity properties  exist in expanding Cosmic Universe, with streaming strings containing organizing  principles, with inner dimensional thinkers tuning into specific harmonic frequencies;  begin experiencing with acuity, insight and comprehension, wondering in infinite spirals of logic in manifold topologies , folding in multitudes of widening horizontal information matrices, combining into primes, ultimate constraints in life.

Properties with maximum interactions will replicate, first, transcription begins with RNAi splicing tiny size: editing linear, circular genomic transcripts imprinted in various allelic genetic loci which is dominant, recessive, combinatorial unique traits, which increase in functional complexity and higher positionings in trait/genetic material DNA/RNA encoding and decoding.

With addition internal inherited, imprinted "wired circuits" in epigenetic programming inherent in constitutional germline, totipotent immunity signals universally broadcasting survival techniques, identity transformation, instinctual premonitions, permitting shifting positions in spherical orbital hyperbolic crystalline lattices fusing into different atomic compositional materials with different functions and properties i.e. proteins, amino acids, nucleic acids, nucleotides, nucleosides, and genomic heptameric seedling primers. 

First, I will primarily investigate: evolution genetic cipher using Inosine, at nucleotide position thirty four and thirty seven in anti-codon, amino acid fusion with resulting  polypeptide chains of protein decoding mechanisms, functioning in highly partitioned calcium ion bridges which recognize unique metabolic signatures. Mapping connective tissue signaling in phosphorylation of alpha helix heptameric amino acid with 52 identical heptad iterations signaling for CTD ( Carboxylic Terminal Domain), coordinating script editing for optimal utilization of minimal spatial coordinates which intersect in non linear, spirals of sequential signals parsing noise interference with non-Euclidean filters simulating tiling of the plane by Felix Klein's Quartic Curve with seven dimensions of independent metrics and identities. 

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