This is huge. I wish I had this 40 years ago: A synthetic transcription platform for programmable gene expression in mammalian cells.
Sustained expression of a protein such as a cytokine or interleukin is essential for the creation of anti-tumor vaccines. It was shown decades ago, that if your tumor cell type would produce just about any interleukin for long enough, it would not only trigger it's own demise but also the demise of it's non-transfected parental tumor cells.
At the time we used CMV promoters that essentially shut themselves off by triggering Ifn-gamma production. Thus, this platform could be the key to making tumor vaccines that actually get the job done.