Hsc70 is a Drug Target for Antiviral and Hsc70 Inhibitors are Antiviral Agents
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Enterovirus A71 (EV-A71) is a small positive-stranded RNA virus that causes human hand, foot and mouth disease (HFMD) as well as fatal neurological disorders, in some cases without effective treatment. Other enteroviruses (e.g., coxsackievirus), flaviviruses (e.g., West Nile virus, hepatitis C virus, dengue virus, tick-borne encephalitis virus, yellow fever virus, Zika virus) and coronaviruses (e.g. SARS-CoV, SARS-CoV-2) also cause infections and can lead to extensive outbreaks in countries worldwide. However, no therapeutic drugs are currently available to treat infections caused by viruses such as EV-A71 and Zika virus. Thus, the opportunity exists to develop novel treatments for these prevalent viruses.
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