How We Beat the Heat in BFS

At ApiJect, our engineers have taken BFS filling enhancements even further by developing proprietary temperature control management methods that can potentially enable many temperature-sensitive biologics and vaccines that are not possible on standard BFS lines. Our experts’ deep experience with fill-finish, combined with our technology, may be able to benefit your drug product development programs.

Expert Insight: How We Beat the Heat in BFS

The strategy to keep the API cool is to offset the heat of the plastic, so that the liquid contents don’t wind up absorbing all that heat. There are several strategies to do this, some inherent to BFS technology and some particular to molds and container designs. <Read Article>

Understanding BFS: The BFS process is divided into five main stages:

1. Extruding:?Heated, liquefied resin is extruded to form a parison within the BFS mold.
2. Blowing:?Sterile air is flushed through the parison as the mold closes and the container is formed.
3. Filling:?Using a time/pressure fill system, an exact amount of drug product is dispensed into the container.
4. Sealing:?The top of the mold comes together, forming an aseptically sealed container.
5. Demolding:?The mold is opened and the filled container(s) are released.

Temperature Management: Watch how ApiJect effectively manages temperature of the drug product throughout the BFS process.

For further information:

Did You Know: Temperature Management Control 1

Did You Know: Temperature Management Control 2