How Does CBD React to Nanoemulsion?

CBD oils and cannabis concentrates are both hydrophobic. Limited water solubility leads to low bioavailability, which means that only a small percentage of cannabinoids are absorbed by the body. Nanotechnology is changing the game today, with better efficacy and quicker onset at lower dosages.?

Explore the exciting new world of CBD nanoemulsions.

Are "old-school" oils and creams set to be replaced by a new generation of CBD products? Although we cannot say for sure now, it is probable that the issue of bioavailability—the extent to which a drug is made available to target cells—will be at issue.

Lower doses are required to produce effects the more bioavailable a dosage is. Because the dosage is administered intravenously and reaches the bloodstream in aqueous form, it is regarded as being 100% bioavailable.

Consuming cannabis and CBD requires careful consideration of bioavailability. Enhancing its bioavailability is the greatest strategy to boost CBD's [1] (or THC's [2]) efficacy without consuming more of it. Because the CBD molecule is hydrophobic, it has a relatively poor bioavailability in oil-based products like CBD oils and creams intended for oral or topical use. Water, which is inevitably the primary component of our bodies, does not combine with cannabinoids [3], which are resinous chemicals.

Nanoemulsion Enhances The Effectiveness Of CBD

New technologies can now break down oily substances into minute particles that are subsequently emulsified into a stable state, overcoming cannabis' inherent resistance to being absorbed into the circulation.

This development has enabled the conversion of CBD oils into more hydration-friendly forms, increasing bioavailability. Today, businesses can create a brand-new generation of CBD and THC oils that are nearly water-soluble thanks to nanoemulsion technology.

What Is Nanoemulsion?

Oil-in-water emulsions are technically mixes where oil is the dispersed phase and water is the continuous phase, frequently stabilised by one or more emulsifiers, also known as surfactants. These surfactants, which may be organic or synthetic, are effective for lowering the surface molecular friction between liquids and oils.

Depending on the size of the dispersed phase particles, emulsions can be macro, micro, or nano in size.

In order to address problems like bioavailability and food consistency, nanotechnology has lately been used to the food and nutrition business. Some of the outcomes are purportedly healthful component nanoemulsions that may be added to any beverage and are compatible with water.

By dissolving the dispersed phase into 10-1,000nm droplets, ultrasonic liquid processors create nanoemulsions. These droplets may be easily transported through the body by a water-based substance of choice and are significantly smaller than the range for traditional macroemulsions (0.1-100 m). Practically speaking, your cannabis will be able to permeate your tissues together with water more readily the more you can break it up.

Advantages Of Nanoemulsion?

Nanoemulsion is being investigated for a number of medicinal purposes, including the delivery of quick-acting antiviral drugs. Currently, more than 60 medications using nanoemulsion technology have received regulatory approval, and research is ongoing [4]. The bioavailability of transdermal -Tocopherol, for instance, may be greatly increased by nanoemulsions, according to a research (a type of vitamin E).

Additionally, nanoemulsions have been created to increase the bioavailability of lutein and curcumin in dietary supplements [5]. The cannabis sector is making the same strides. To increase intestinal absorption, CBD and other cannabis constituents in oil form can be nanoemulsified into new formulations [6].

Pharmaceutical-grade cannabis nanoemulsions have been created by a select few cutting-edge labs, who claim that the nanoemulsified version of CBD they use has an instantaneous onset, a considerably faster absorption rate, and therapeutic benefits at lower dosages. Natural absorption boosters like piperine are also included in certain next-level nanoemulsified cannabis formulations [7].

Nanoemulsion Disadvantages

The expense of manufacture is this technology's biggest flaw. Naturally, nanoemulsified CBD products cost more than traditional CBD oils. They may also have various effects.

In exchange for a more difficult "landing" after the benefits wear off, nanoemulsions may provide more alleviation from pain or anxiety. Even while CBD is thought to be harmless, their enhanced bioavailability also indicates increased risk for negative effects. Finally, there aren't many impartial evaluations available online just now because just a few firms are selling these new items.

Liposomes And Nanoemulsion Comparison

Liposomes are yet another modern, well-established technology in the pharmaceutical industry.

Liposomes can deliver active chemicals to specific body parts without their deteriorating during transit via the digestive system. Greater bioavailability is achieved as a result of the substances inside these small spheres being shielded until they reach their intended recipient.

The nutraceutical and CBD businesses are currently using liposomes to increase bioavailability and safeguard priceless compounds without any negative side effects. This method of drug administration may be used to make nanoemulsion-like CBD oil and water mixes, which are more bioavailable than normal oils. Liposomal CBD will continue to be one of the safest and most effective delivery methods until nanotechnology becomes commonplace.

Is Nanoemulsion CBD Oil The Future?

Nanoemulsions are anticipated to earn a decent spot on medical cannabis shelves because to their excellent physical stability and quick absorption, which enable bioavailability ratios similar to intravenous delivery.

Despite encouraging first results, clinical research on this administration form of CBD is still in its very early stages and does not really make CBD water soluble. However, nanotechnology applications in cannabis derivatives are undoubtedly more than simply marketing gimmicks. The full potential effects of nanoemulsions, nanoencapsulated phytochemicals, even nanocrystals and polymeric micelles, are still to be explored.

References

[1] Everything you Need to Know About CBD (Cannabidiol)

[2] What is THC?

[3] The role of the endocannabinoid system in the regulation of endocrine function and in the control of energy balance in humans

[4] Increased bioavailability of a transdermal application of a nano-sized emulsion preparation

[5] Improving the Oral Bioavailability of Curcumin Using Novel Organogel-Based Nanoemulsions

[6] Development of a Novel Nanoemulsion Formulation to Improve Intestinal Absorption of Cannabidiol

[7] The effect of Pro NanoLipospheres (PNL) formulation containing natural absorption enhancers on the oral bioavailability of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in a rat model