How to deliver your target Oligonucleotide into cells?
Targeted delivery of Oligonucleotides (Oligos) to cells is a critical aspect of therapeutic approaches in gene therapy, RNA interference (RNAi), antisense RNA therapy or CRISPR-Cas9. Efficient delivery systems are required to ensure that the oligos reach their target tissue and cells, avoid degradation by nucleases and penetrate the cell to access intracellular targets. In this newsletter we have compared two different conventional methods, Lipid-based Nanoparticles and Sugar based delivery systems, as tools for the transport of Oligos into cells.