How Collaboration and Early Detection Can Move the Needle in Cardiovascular Disease

How Collaboration and Early Detection Can Move the Needle in Cardiovascular Disease

People often ask me what drove me into the private sector and to pharma, and I’ve had time to reflect on my unconventional entry to the industry – which in many ways started in Africa. Early in my career, I worked across many countries in Africa on some of the most pernicious diseases of our time – like HIV/AIDS, malaria and tuberculosis. I worked on improving treatment access and trying to find ways to increase the number of qualified health workers to provide care. It was during those early years of my career that I saw the impact innovation can have in diseases of massive scale that affect large populations.

Given my personal history, I was excited at the opportunity to return to Africa on a recent trip with the Novartis Foundation, as a member of their Board of Trustees. One of the most inspiring parts of the trip, which made me reminiscent of the early years I spent in Africa, occurred in Ghana – where the Novartis Foundation and several of our partners are working to bring innovative approaches and thinking to another area of mass scale and unmet need – cardiovascular disease. More than 80% of cardiovascular deaths occur in low and middle-income countries (LLMICs) – but the disease continues to be one of the more underestimated threats to the African population.

While in Ghana, my colleagues and I met with program officers from the Community-based Hypertension Improvement Project (ComHIP), an innovative healthcare model designed to improve hypertension management and control. ComHIP is a collaborative effort between the Novartis Foundation, the nonprofit human development organization FHI 360, Ghana Health Service, the London School of Hygiene & Tropical Medicine, the Ghana School of Public Health and VOTO Mobile which works to address one of the biggest challenges at the heart of the cardiovascular disease problem – access to screenings for hypertension. As recommended by the National Academy of Medicine in its Global Health report, early detection and treatment of hypertension is crucial for addressing cardiovascular disease at the country-level. But without the tools and trained field staff to drive those regular screenings in more rural areas, cardiovascular disease is reaching a critical point in Africa. ComHIP tackles this problem head-on by offering hypertension screening in local pharmacies, meaning it’s often more accessible for people than hospitals. While in the area, I was even able to get screened myself through their simple but highly effective process.

I am grateful to have had the opportunity to see this work firsthand, alongside renowned public health physician Dr. Peter Lamptey who’s dedicated much of his career to HIV/AIDS and more recently hypertension and bringing better medical care to the developing world. Taking on a public health challenge like cardiovascular disease – which according to the WHO is the number 1 cause of death globally – is daunting, even in areas where access to care and treatment is optimal. However, the collaboration at the core of efforts like ComHIP, and the dedication of all those involved gives us reason to be optimistic – and to partner to pursue innovative, scalable solutions to problems of any magnitude. 

Shameer Khader, Ph.D, MPH

Executive Director at Sanofi | Data Science, Bioinformatics, Biometrics & Drug Discovery | Digital Health | GenAI | Data & AI Strategy | Precision Medicine | ML & Analytics Leadership | Genomics | Computational Biology

6 年

Hi Vas, Agree with your view on approaching cardiovascular drug discovery with the power of data and machine intelligence. However, we lack some fundamental resource in this space when compared to other therapeutic areas (like oncology). For example, Cardiology lacks a centralized resource like The Cancer Genome Atlas. I strongly , building a Cardiovascular Disease Atlas by collecting longitudinal phenomic data integrated with multi-omics profiling and outcome could be the foundation for precision cardiology. As a data-driven drug discovery leader, hope Novartis would invest in building key resources to enable accelerated diagnoses, interventions and improving outcomes. We discuss some of the opportunities and challenges in enabling precision cardiology here: https://basictranslational.onlinejacc.org/content/2/3/311

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Kare Anderson

★ Speaker TED (over 2.6 mil views) ? author Mutuality Matters & Opportunity Makers ? Emmy winner ? Moving From Me to We

6 年

Again the specificity of your ideas and experience in scalable ways organization can collaborate to make a healthier world truly inspire me Vas Narasimhan - and that is why I cite you and your work, when speaking on behalf of Novartis to client groups in the U.S. as an "unbranded speaker" on connective behavior

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Michael Mihut, MD MBA

Strategic manangement in public health and biomedical research, innovation and ethics

7 年

lovely personal story!

Bright Abhulimen

Inside Sales Advisor at Accenture

7 年

Nice article Vas also inspiring. In Nigeria community Pharmacies now render free checks for blood pressure and have being able to bring to the fore the need to check blood pressure regularly. Challenge usually is with poor adherence and compliance to medications due to several factors like exorbitant price in medications and false information from companies selling supplements like Omega-3, Garlic and co who misinform many that taking such pills will bring their blood pressure under good control Also their are misconception in some areas that with herbal concoction hypertension Disappears but with more health Education from community Pharmacies these are being addressed

Dasy (Hadas) Mandel

HealthTech Investor | Founder & CEO

7 年

Dear Vas, thank you for publishing this project. I’d like to share with you another project that my company is supporting for the diagnosis, prevention, and control, of cardiac disease. At LevMed we provide a simple, affordable, Mobile 12-lead ECG solution. Our LevMed Mobile ECG Kit includes our ECG Belt and a small mobile ECG transmitter, allowing anyone to perform a hospital grade 12-lead ECG assessment, anywhere in the world. No clinical knowledge or experience is required. In our project in Kitovu Hospital, a rural missionary hospital in Masaka, Uganda, using our system, they went from zero ECGs to almost 2,000 in 10 months. From this ongoing project we have learned 2 main lessons: First, 20% of the patients suffer from LVH, but were previously not diagnosed, as ECGs were not performed in the past, and, second, with our Mobile ECG Kit the hospital can sustain a valid business model that will allow all patients to be screened. You can see an interview with Dr. Martin Opio, the Medical Director of Kitovu Hospital, and a demonstration of the use of our Mobile ECG, in the following link: https://www.youtube.com/watch?v=etIH-o7-Sbw I'd be very happy to share more information with you as I believe our product is well complementary with Novartis Access activities in developing countries. Thanks, Hadas.

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