Highly cited article in "Regenerative Biomaterials": How to design multi-responsive hydrogels for drug delivery and tissue engineering

Multi-responsive hydrogels, or ‘intelligent’ hydrogels that respond to more than one environmental stimulus, have demonstrated great utility as a regenerative biomaterial in recent years. They are structured biocompatible materials that provide specific and distinct responses to varied physiological or externally applied stimuli. As evidenced by a burgeoning number of investigators, multi-responsive hydrogels are endowed with tunable, controllable and even biomimetic behavior well-suited for drug delivery and tissue engineering or regenerative growth applications. This work encompasses recent developments and challenges regarding supramolecular, layer-by-layer assembled and covalently cross-linked multi-responsive hydrogel networks and their application to drug delivery and tissue engineering. Jennifer M. Knipe Nicholas A. Peppas Regenerative Biomaterials, Volume 1, Issue 1, 1 November 2014, Pages 57–65, https://doi.org/10.1093/rb/rbu006