The health benefits of inositol in female fertility

Inositol is a molecule commonly referred to as a B-vitamin, although this is not a legitimate claim and it is more of a pseudovitamin (vitamin-like) compound due to its prevalence in the diet and importance in the body. ?Inositol is a small molecule with structural similarity to glucose and it is involved in cellular signalling and is present as a component of cell membranes. Inositols are found in most foods but in highest levels in whole grains and citrus fruits.

There are nine different inositol molecules, but the majority of supplementation is in the form of myo-inositol, as this is the body's main steroisomer (comprising over 90% of cellular inositol with scyllo-inositol coming in second place).

Myo-inositol shows the most promise as a dietary supplement for promoting female fertility, by restoring insulin sensitivity in instances of resistance (type II diabetes and polycystic ovarian syndrome (PCOS) being the most investigated). Due to the mixed benefits to insulin resistance and fertility, myo-inositol is considered a good treatment for PCOS in women. In part because of its benefits to fertility and PCOS, as well as the anxiolytic effects potentially helping symptoms of PMS (dysphoria and anxiety mostly), myo-inositol is sometimes referred to as a general female health supplement.

PCOS is a condition affecting women that is associated with high androgens, reduced fertility, impaired weight loss, and these problems seem to stem from insulin resistance. As myo-inositol is thought to alleviate insulin resistance, it is being investigated for its role in PCOS.

PCOS is known to impair female fertility over the long term and supplementation of inositol (over 12 weeks) has been noted to restore menstruation in women who have transiently lost their periods due to PCOS. In vitro fertilization as well as overall pregnancy rates in women with PCOS are improved with supplementation of myo-inositol, and it appears that the symptom of oligo/amenorrhea (disrupted or absent periods) from PCOS can also be alleviated with supplementation.

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