GLP-1 Agonists - 3 injectables to watch out for!

!1?? ?????????????????????? - ?????? ??????????A triple agonists (GLP-1, GIP and glucagon GLP-1 + GIP agonist), a triple agonist from Lilly

???????????????????????? ???????????? ????????, ?????????????????? ????????????

Trial data from PII trial of ????????-???????????? ?????????????????? in obesity in 338 participants without diabetes for 24 and 48 weeks indicate that the product achieved weight reductions of 17.5% and 24.2% at week 24 and 48 (vs 1.6% and 2.1% for the placebo)

???????????????????? ???? ?????????????? ???????? ???????????? ????????The reduction curve did not plateau, implying that there was potential for additional weight loss if treatment was not stopped??Phase III (TRIUMPH) in obesity launched, with data readout expected in 2026

2?? ?????????????????? -???????? ??????????????Combination of semaglutide and an amylin analog (cagrilintide) which has a synergistic effect on body weight

???????????????????????? ???????????? ????????CagriSema showed weight loss ranging from 15.7% (cagrilintide 1.2mg) to 17.1% (cagrilintide 2.4mg) at week 20 in a phase Ib trial

?????????? ???? ???????????????? ???? ???????? ??????????????

3?? ???????????????? -??????????

A GLP-1 agonist + GIP antagonist

???????????????????????? ???????????? ???????? Phase 1 data shows weight loss up to 14.5% (at the highest dose) by day 85

?????????????? ?????????????? ???????????? Interestingly, the drug could produce longer-lasting effects compared to Wegovy and Zepbound) signifying less-frequent dose

Disclaimer: The chart also represents certain non-GLP-1 agonists as part of the obesity landscape

??????????????????????????'?? ??????????????????????: Weight loss alone is not the benchmark for comparing GLP-1 drugs in obesity -Preservation of muscle mass, convenient dosing (injection versus oral dosing), clinical benefit in other co-morbid conditions and pocket friendly access plans have a significant role in determining which drug finally wins the "sustainable" market share in this billion dollar market.

Interested to know more about the potential gamechangers in the GLP-1 market - DM your email address and any specific questions and we will try to answer those questions in our upcoming report - "??????-?? ???????????????? ?????????????????? ??.?? -?????? ??????????????????????"

#GLP-1

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