?? Global Brain Health Innovations ??

The Regents of the University of California invented a method and system for treating affective disorders such as depression and/or anxiety and/or related disorders through neuromodulatory intervention that includes brain targets within the orbitofrontal cortex (OFC). This method includes the application of electrical stimulation through an electrical signal generator device where the distal end of the device comprises at least one stimulating electrode in contact with the OFC. The treatment system includes patient selection, implantation of at least one stimulating electrode in contact with the OFC, acute or chronic electrical stimulation of the OFC, and evaluation of the effects of stimulation on clinical symptoms and status.

Application: 18544206

Dandelion Health DANDELION SCIENCE CORP. invented the systems and methods for optimizing the processing of sensory information, refining diagnostic approaches for neurological disorders, and introducing novel methods for controlling brain network activity.

Application: PCT/US2024/011453

Itzhak Fried Itzhak FRIED et. al., disclosed memory enhancement by prefrontal deep brain stimulation synchronized to medial temporal lobe during sleep; closed-loop neuromodulatory system comprises one or more processors and memory. The system is configured to record signals from a first region of a brain of a human subject during sleep via a first electrode. The system is configured to determine, from the recorded signals, active periods of the first region. The system is configured to stimulate a second region of the brain, different from the first region, during the active periods via a second electrode that is electrically coupled to the first electrode via closed-loop control.

Application: 18563692

RYNE BIOTECHNOLOGY INC. disclosed a method of generating a population of cells useful for treating a brain disorder in a subject is disclosed. This disclosure provides compositions and methods to modify miR-155 in pluripotent cells, to differentiate the engineered pluripotent cells to disproportionately yield 155-3p or 155-5p in DA neurons and engraft the miR-155-3p or miR-155-5p biased DA neuron progenitors, astrocytic progenitors and/or leptomeningeal progenitors in a human subject to produce an anti-inflammatory effect.

Application: PCT/US2024/011103

Imam Abdulrahman Bin Faisal University Imam Abdulrahman Bin Faisal University invented a method of controlling robotic arm based on brain activities. The method includes measuring HbO level of non-disabled subject at target brain areas during wrist movement using a fNIRS device with light sources and detectors. The method further includes detecting brain activities of non-disabled subject through said detectors based on HbO level of non-disabled subject during wrist movement, and classifying brain activities corresponding to wrist movement using classification algorithms and generating training data set. The method also includes generating control signals based on brain activities for robotic arm to perform wrist movement, and detecting brain activities of disabled subject at target brain areas based on HbO level using fNIRS device. The method includes analyzing brain activities of disabled subject based on training data set, and generating control signal for robotic arm to perform wrist movement based on analyzed brain activity of disabled subject.

Application: 18154083

Washington University in St. Louis Washington University a compositions and methods for the treatment, prevention, or reversal of a central nervous system (CNS) injury or disorder in a patient in need that include administering a therapeutically effective amount of meningeal immune cells are disclosed. Specifically, the meningeal immune cells comprise Ly6C+ monocytes. Further disclosed are wherein the meningeal immune cells are modified to include a drug or gene therapeutic compound, and wherein the modified meningeal immune cells are configured to deliver the drug or gene therapeutic compound to the CNS of the subject via the parenchyma or meningeal tissue of the subject.

Application: 18560263

Vanderbilt University Vanderbilt University disclosed compounds for the treatment of the movement associated neurodegenerative disorders, such as e.g. Parkinson's disease, drug-induced Parkinsonism, dystonia, Tourette's syndrome, dyskinesias, schizophrenia, cognitive deficits associated with schizophrenia, excessive daytime sleepiness, attention deficit hyperactivity disorder (ADHD), Huntington's disease, chorea, cerebral palsy, and progressive supranuclear palsy.

Where compounds are: (6-((octahydrocyclopenta[c]pyrrol-5-yl)amino)pyridazin-3-yl)benzamide (R2b is —C(O)N(RA1)(RA2) and N-(6-((octahydrocyclopenta[c]pyrrol-5-yl)amino)pyridazin-3-yl) phenyl) carboxamide (R2b is —N(RB)C(O)RC) derivatives

Application: 18553412

Comind Technologies CoMind Technologies Limited invented Event Related Optical Signal Neuroimaging and Analysis System for Monitoring Activity of a Subject's Brain.

Event related optical signal, EROS, neuroimaging and analysis system for monitoring activity of a subject's brain, the system comprising: a first wavelength-swept light source configured to provide wavelength-swept emission of coherent light; and a plurality of light detectors; wherein the first wavelength-swept light source is arranged to both: (i) deliver the light towards the subject's brain tissue to be scattered to the detectors, and (ii) deliver the light to each of the detectors via one or more reference channels; wherein each of the light detectors comprises: a first input port arranged to receive scattered light from the subject's brain tissue; a second input port coupled to one of the reference channels to receive reference light from the first light source; a light combiner connected to both the first input port and the second input port for combining the scattered light received from the subject's brain tissue with the reference light received from the reference channel to provide a combined light signal comprising a component at a beat frequency for the scattered and reference light; and signal processing circuitry configured to provide neuroimaging and analysis based on the combined light signal.

Application: 18033443