?? Global Brain Health Innovations ??
Evgenia Leonova, PhD, MBA
Life Sciences Executive, Entrepreneur, Lecturer, Speaker
E?TV?S LORáND TUDOMáNYEGYETEM invented a novel approach toward the vascular dementia diagnosis. Declining cerebral blood flow leads to chronic cerebral hypoperfusion which can induce neurodegenerative disorders, such as vascular dementia. The reduced energy supply of the brain impairs mitochondrial functions that could trigger further damaging cellular processes. Altered levels of protein biomarkers are discloses to be useful in the diagnosis of vascular dementia.
Kwang Hyun JANG invented NOSE FLUTE CAPABLE OF IMPROVING BRAIN SENSATION AND COGNITION. The present invention relates to a nose flute capable of improving brain sensation and cognition and, more specifically, to a nose flute having a novel structure, which is a musical instrument that can be played using nasal air, so that brain sensation and cognition can be improved while sound width, sound and sound tone can be accurately implemented with accurate notes. To this end, the present invention comprises: a front body part in close contact with the body of a user; a sound generation part for generating sound of a preset height while the nasal air generated by the user flows therein through one end thereof and is discharged through the other end thereof; and a rear body part for fixing positions of the front body part and the sound generation part, and sealing the sound generation part so that same is not exposed to the outside.
AlonTree Company invented therapeutic game for stroke survivors improving fine and gross motor skill.
The present invention provides a therapeutic game for holistically engaging people who have had a stroke or other brain injury in gross and fine motor skill activities. The therapeutic game is a self-contained set of objects that can be placed on or in a set of targets. Targets can be openings within a container in which to drop or toss the objects. A target can be a daisy support with a base, stem, and receptacle removably attachable to the stem on which or in which an object can be placed. A scoring system can also be used mark progress and to engage the mental powers as well as the physical powers.
WASHINGTON UNIVERSITY, THE GENERAL HOSPITAL CORPORATION invented the methods and systems for modulating unconsciousness or anesthesia in a subject.
Among the various aspects of the present disclosure is the provision of methods and systems for (i) modulating, enhancing, or maintaining slow waves using phase-locked neurostimulation; (ii) modulating, enhancing, or maintaining unconsciousness; or (iii) reducing the amount of anesthesia required in a subject. Briefly, therefore, the present disclosure is directed to applying neurostimulation to the brain of a subject to enhance anesthesia, thereby decreasing drug requirements of anesthesia.
The Children's Medical Center Corporation, Ospedale San Raffaele S.r.l. invented The present invention provides compositions and methods for the treatment or prevention of a neurological disease or disorder of the central nervous system (e.g., a storage disorder, lysosomal storage disorder, neurodegenerative disease, etc.) by reconstitution of brain myeloid cell and microglia upon transplantation of hematopoietic cells enriched in microglia reconstitution potential. The invention also provides compositions and methods for ablating and reconstituting microglia.
THE UNIVERSITY OF MINNESOTA invented a method for producing a multi-tissue organoid generally includes obtaining pluripotent stem cells (PSCs) and inducing growth of the multi-tissue organoid by culturing the harvested PSCs in suspension in a culture vessel. Another method for producing a multi-tissue organoid generally includes introducing a pluripotent stem cell into a cell culture medium comprising hyaluronic acid, transferring the pluripotent stem cell to a cell culture device that does not include a three-dimensional matrix, culturing the pluripotent stem cell in the cell culture device for at least 1 week, and producing a multi-tissue organoid comprising cartilage, bone, fibrous connective tissue, brain tissue, or epithelial tissue, or a combination thereof.
CASE WESTERN RESERVE UNIVERSITY invented a system to treat a target area of a patient's brain can include at least one external electro-optical applicator and at least one window spanning beneath skin covering a skull of the patient and through obstructive material of the skull of the patient. Each electro-optical applicator can include at least one light source and at least one electrical source. Each window can include at least one electrode proximal the target area and a conductive path to the at least one electrode. The at least one window can be configured to: transmit a light signal from the at least one light source through the window to the target area of the brain of the patient; and deliver an electrical modulation from the at least one electrical source via the at least one electrode to the target area.
Mitsubishi Electric Corporation invented a biological information detection device includes an administration mechanism (10) to administer magnetic particles into a brain, the magnetic particles being bound to a target inside the brain, a first varying magnetic field application mechanism (12a, 12b) to apply a first varying magnetic field to the magnetic particles from outside the brain, a magnetic signal detection mechanism (13a, 13b) to detect a magnetic signal generated by the magnetic particles bound to the target due to the first varying magnetic field, and a determiner (14) to determine an amount of the target based on a strength of the magnetic signal.
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EUROPEAN BRAIN RES INSTITUTE EBRI R LEVI MONTALCINI invented the method for the early diagnosis and the monitoring of the evolution/regression of neurodegenerative pathologies, said method providing for the quantification of a. biomarker for said pathologies in a fluid that was previously drawn from a. patient, said fluid being selected from among: cerebrospinal fluid; serum; urine; post mortem cerebral tissues and cellular lysates, said method being characterized in that the quantified biomarker is selected from among native proNGF; modified proNGF, the latter being proNGF in its forms with higher molecular weight, including forms of 39-40 kDa and 45-50kDa; NGF; and the proNGF/NGF ratio, said method sequentially providing for the fol lowing steps of Preparation of the biological sample, Definition of the calibration curve; Execution of run and interpolation.
THE FRANCIS CRICK INSTITUTE LIMITED invented TREATMENT FOR CDKL5 DEFICIENCY DISORDER. Disclosed herein are methods and agents for the treatment and/or prevention of cyclin dependent kinase like 5 (CDKL5) deficiency disorder. In particular, disclosed herein are compounds or compositions for increasing cyclin dependent kinase like 2 (CDKL2) in a subject, such as in the brain of a subject, and the use of those compounds and compositions in methods of treating CDKL5 deficiency disorder.
BOSTON SCIENTIFIC NEUROMODULATION CORPORATION invented a method for optimizing stimulation for a patient having a stimulator device such as a Deep Brain Stimulation (DBS) device is disclosed, which involves a consideration of tissue imaging information in the environment around the lead. Test stimulation is provided at initial combinations of lead positions and values of a stimulation parameter such as amplitude, with patient results scored for each combination. Tissue imaging information is assessed in conjunction with these scores, and a next combination of position and a value of the stimulation parameter to test is determined. This process repeats iteratively until a stopping criterium is met. The lead positions in question may be longitudinal or rotational positions around the lead, and preferably both if the lead is directional in nature. Tissue imaging information can also be used to exclude certain positions or stimulation values during subsequent optimization testing.
ALIS PHARMA LTD. invented a fetal sheep brain extract for managing neurodegenerative diseases，an implant or a pharmaceutical composition comprising the fetal sheep brain extract. A method for manufacturing the fetal sheep brain extract, comprising the steps of: (a) collecting brain tissue from fetal or newborn sheep;(b) homogenizing the collected brain tissue to obtain homogenate;(c) filtrating and/or centrifuging the homogenate to obtain a filtrate; and (d) purifying/processing the filtrate further to obtain the final product. Use of the fetal sheep brain extract for the manufacturing of a medicament for managing neurodegenerative diseases.
UNIV AIX MARSEILLE
INST NAT SANTE RECH MED
The invention relates to a deep brain stimulation system comprising at least four stimulation pairs of electrodes, each stimulation pair of electrodes providing an electric stimulation at a carrier frequency, the mean value between the carrier frequency of any first stimulation pair of electrodes and the carrier frequency of any second stimulation pair of electrodes defining a first mean carrier frequency, the mean value between the carrier frequency of any third stimulation pair of electrodes and the carrier frequency of any fourth stimulation pair of electrodes defining a second mean carrier frequency, system wherein the difference between said first and second mean carrier frequencies is equal to or greater than 200 Hz.
POCKIT DIAGNOSTICS LTD invented D-dimer, gial fibrillary acidic protein (GFAP) osteoprotegerin (OPG) and osteopontin (OPN) as biomarkers for stroke caused by large vessel occlusion. The invention relates to the diagnosis of stroke resulting from occlusion of one or more large vessels in the brain, and in particular to the diagnosis of stroke resulting from occlusion of one or more large vessels in the brain (large vessel occlusion; LVO) using one or more biomarkers. The biomarkers measured from the patient are D-dimer and glial fibrillary acidic protein (GFAP). The method further comprises determining a stroke severity score of the patient, selected from FAST, FAST-ED, RACE, C-STAT and EMSA scores.
Maurice M. Klee invented charge-based methods for modifying neural activity. This disclosure relates to methods for modifying neural activity by applying electrical current to a neural tissue, e.g., in a transcranial DC stimulation procedure (tDCS), a transcranial AC stimulation procedure (tACS), a transcranial random noise stimulation procedure (tRNS), a deep brain stimulation procedure (DBS), a transcutaneous electrical nerve stimulation procedure (TENS), or the like. Historically, computed potential, electrical field, and/or current density distributions have been used to select the locations of the electrodes that apply the electrical current. In the present disclosure, a computed charge distribution on the bounding surface of one or more sulci filled with cerebrospinal fluid (CSF) is used in selecting the electrode locations. In one embodiment, the sulcus's bounding surface is divided into pixels and each pixel's charge is determined by the pixel functioning as a sensor for the charges surrounding it, including the charges of other pixels and the charges on the electrodes.
CODEXIS, INC. invented a method of preparing neural spheroids, the neural spheroid prepared by the method, and uses of the neural spheroids. In some embodiments, the present disclosure provides a method of forming neural spheroids, a three dimensional network of cells comprising neural and glial cells, where the method comprises culturing differentiated fore brain progenitor cells in a cell culture well having an ultra-low attachment surface and shaped to promote self-assembly of cells into neural spheroids.
Worcester Polytechnic Institute invented a method for directing an electrostimulation therapy includes receiving a scan image of a treatment region and determining a purported location of a stimulation probe inserted within the scan image. A modeling application or computational engine determines a position of a target region within the scan image relative to the purported location, and computes a strength of the electrical energy at the position based on a Fast Multipole Method (FMM) using LU (Lower/Upper) factorization, and concludes an efficacy resulting from activation of an electrode delivering the electrical energy resulting from the stimulation probe at the purported location.