FoxA2

Author Silvia Bürkle ?- HQ Metabolic Balance? - Company

FOXA2 - The fat burning enzyme

In the human body, there is a molecular switch, a protein called FoxA2, that turns on or off a complicated loop of dozens of messengers. This mechanism was first discovered and described by scientists at the Swiss Federal Institute of Technology (ETHZ) in Zurich. Experimenting with mice, they found out that FoxA2 function is closely related to the urge to move and the search for food.

They observed that obese mice were lazy and sluggish compared to their slimmer counterparts - no matter whether they were fed or not. Upon closer inspection, it was then discovered that FoxA2 was inactive in the obese mice. This is caused by our key hormone insulin, which is elevated in obese mice - as it is in overweight people, too. Insulin seems to block the FoxA2 enzyme.

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FoxA2 is found in the liver, where it regulates fat burning. It gives the signal that switches metabolism to fat burning mode and mobilizes stored fatty acids from fat cells. However, if FoxA2 is inactivated, fatty acids are not burned and are not converted into so-called ketone bodies, which are needed by muscles and the heart, for example, as "food" to produce their energy.

If there is no insulin available, as is also the case in a fasting state, for example, FoxA2 is all the more active. The experiment also showed that the animals in which FoxA2 was active had an extremely strong urge to exercise. They also lost more fat tissue and built up more muscle mass. Their sugar and fat metabolism worked at full speed and their blood values improved significantly.

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FoxA2 controls the urge to move

Constantly available food is poison for our metabolism. Especially the simple sugars contained in soda or processed snacks spike the insulin level. And it is precisely these permanently elevated insulin levels that switch off FoxA2. Consequently, fat burning comes to a standstill, and besides another signaling pathway is blocked that motivates us to spontaneous exercise. FoxA2 is also found in the brain, where it stimulates the production of orexin. Orexin, also a protein, is responsible for increased attention and spontaneous urge to move.

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So if your clients, the so-called "couch potatoes", after 2 to 3 weeks of dietary change feel an increasing urge to move, this does not mean that they are sick or do not feel well with the dietary change; on the contrary, now the enzymes are in full swing and begin to find their normal rhythm and work.

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