The Flow State Apprentice #7
Sweetwater Holistic LLC

The Flow State Apprentice #7

Cannabis & The Opioid Epidemic - How Medical Cannabis Reduces Opiate Death

In this video, we explore how cannabis improves the quality of life for patients at end-of-life dealing with chronic pain, how it can work together with opioids, and even how it can help with opiate withdrawal symptoms.

While many studies have been conducted on this topic, it is the totality of the data that truly showcases the potential of medical cannabis as a complementary therapy to traditional opioid treatments.

Sweetwater Holistic LLC


Herbal Gateways to Neuroprotection: Unveiling the Role of Gut Microbiota

The relationships between plant medicine and the gut microbiota hold immense untapped potential for innovative neuroprotective treatment strategies.

Medicinal plants exhibit neuroprotective effects by modulating the gut microbiota composition to reduce systemic inflammation and enhance gut barrier integrity.

Source: Guan Y, Tang G, Li L, Shu J, Zhao Y, Huang L, Tang J. Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management. Arch Pharm Res. 2024 Feb;47(2):146-164. doi: 10.1007/s12272-023-01484-9. Epub 2024 Jan 15. PMID: 38225532.

The authors of this paper state: “This interplay between herbal medicine and the gut microbiota appears to extend to neurodegenerative diseases, where modulation of the gut microbiota could mitigate neuroinflammation and oxidative stress—two central pathological features of neurodegenerative diseases.”

Sweetwater Holistic LLC


CBD Reduces Inflammation and Improves Heart Health in Mice: Research Review

CBD treatment significantly reduced inflammation markers in mouse hearts, improving cardiac function, and diminishing inflammation, heart injury, and myocardial fibrosis.

The authors of this study stated: “CBD treatment significantly attenuated mRNA expression of the proinflammatory IL-6, IL1β and IFN-γ”

Sweetwater Holistic LLC


Altered Endocannabinoid System Metabolism in Depression?

A study of patients diagnosed with depression suggests a potential alteration in the endocannabinoid system's metabolism in individuals with depression.

Source: Comai S, Nunez N, Atkin T, Ghabrash MF, Zakarian R, Fielding A, Saint-Laurent M, Low N, Sauber G, Ragazzi E, Hillard CJ, Gobbi G. Dysfunction in endocannabinoids, palmitoylethanolamide, and degradation of tryptophan into kynurenine in individuals with depressive symptoms. BMC Med. 2024 Jan 25;22(1):33. doi: 10.1186/s12916-024-03248-8. PMID: 38273283; PMCID: PMC10809514.

The study's authors state: “This exploratory study demonstrates for the first time in humans a plausible association between the eCB system and the Trp to 5-HT and Kyn pathways in the modulation of mood, as emerged by integrated parametric and non-parametric analysis of the data.

Sweetwater Holistic LLC


Cannabis Improves Quality of Life and Pain at End of Life

A study of cancer patients near the end of life discussed the advantageous impact of cannabis on palliative cancer care.

The cannabis, characterized by differing concentrations of THC and CBD was linked to significant improvements in pain, emotional distress, and sleep disturbances.

The study categorized treatments into THC-dominant (57% of cases), CBD-dominant (19%), and mixed compositions (33%).

Remarkably, within just one month of cannabis utilization, patients reported notable enhancements in pain intensity, both affective and sensory aspects of pain, sleep quality and length, cancer-related distress, and the burden of physical and psychological symptoms.

Source: Aviram J, Lewitus GM, Vysotski Y, Uribayev A, Procaccia S, Cohen I, Leibovici A, Abo-Amna M, Akria L, Goncharov D, Mativ N, Kauffman A, Shai A, Hazan O, Bar-Sela G, Meiri D. Short-Term Medical Cannabis Treatment Regimens Produced Beneficial Effects among Palliative Cancer Patients. Pharmaceuticals (Basel). 2020 Nov 30;13(12):435. doi: 10.3390/ph13120435. PMID: 33265945; PMCID: PMC7761379.

CBD vs THC types showed minimal differences in their efficacy concerning pain intensity and most other measures.

However, THC-dominant strains were distinctively more effective in extending sleep duration than CBD-dominant cannabis.

The authors of the study state: “This work provides evidence that, though patients usually consume THC-dominant products, caregivers should also consider CBD-dominant products as a useful treatment for cancer-related symptoms.”

Sweetwater Holistic LLC


The Flow Formula - Unlocking Peak Performance in Music, Art, and Sport

Flow states, often described as being "in the zone," are psychological states characterized by complete absorption in a task, resulting in heightened focus, productivity, and a sense of enjoyment and fulfillment.

Individuals experiencing flow frequently have clear goals and a high level of dedication.

Think of a musician, painter, martial artist, or athlete practicing over and over, engaging in their tasks for extended periods.

Another dimension is feedback about the process because during flow we need to know how our performance is going.

Sweetwater Holistic LLC


Flow State Consulting Services

Dr. Jake F. Felice - Westport, WA

Step into Flow

Dr. Jake F. Felice, N.D., L.M.P. Biography

Founder, Sweetwater Holistic LLC

Dr. Jake F. Felice, ND, LMP, provides world-class education experiences by speaking authentically about natural health, flow states, and whole-body wellness.

He is an author, clinician, educator, and consultant whose vision is to advance the science and practical application of natural medicines for medical and recreational markets worldwide.

He grew up in Western Pennsylvania and attended Penn State University, where he played varsity lacrosse and majored in psychology.

As a young man, Dr. Jake was fascinated with Asian cultures and spent five years in Japan, where he studied shiatsu, aikido, and tai chi. After his studies in Japan, Dr. Jake spent a year motorcycling through Thailand, Nepal, and India, where he studied traditional healing arts.

Dr. Jake’s educational materials foster connection with the natural world, enhance human potential, raise awareness, and bring attention to the therapeutic properties of botanicals, homeostasis, and synergistic principles in nature.

His Category 1 CME courses for doctors on the ECS have now been translated into four languages. Dr. Felice is the founder of Sweetwater Holistic Consulting LLC. His passion is coaching flow-state access for high-performing men in athletics and business. He also advises dietary supplement and cannabis companies regarding optimal botanical product development.

Dr. Felice has consulted for major cannabis companies, including Willie Nelson’s brand, Tilray Inc., Manitoba Harvest, Smith & Sinclair, WorldLink Medical, Cannabis Basics, Medical Marijuana 411, Seattle Central College, The National University for Natural Medicine, the University of Las Vegas Nevada, the Academy of Cannabis Science, and the American Academy of Cannabinoid Medicine. He educates doctors, nurses, and cannabis professionals, including creating AMA-approved CEU classes for physicians.

As a consultant, advisor, and brand strategist, Dr. Felice provides scientific, marketing, public relations, and compliance advice for companies in emerging and existing cannabis markets.


I hope that you enjoy this week’s newsletter.? Please comment, like, and share with others.? Many thanks! -Dr. Jake

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kenya Allen

Certified Strength Coach

8 个月

??

Exploring the natural remedies and the capacity of the human mind truly aligns with the wisdom of Hippocrates who once said - Let food be thy medicine and medicine be thy food. ?? Your deep dive into the potentials of cannabis and herbal therapies opens up avenues for holistic healing and prevention. Keep igniting those conversations and inspiring innovation in healthcare! ???

Nina Z.

Conscious Cannabis Connection Guide | Concierge Service | Connector?? | Psychedelics & Cannabis Stigma Erasure | Cognitive Liberty | It's All About People | Patient Advocate | Friend of AI | #EverythingWillBeUkraina????

9 个月

Thank you for all your noble work, Doctor.

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Stacy Naugle Diabetes Reversal Expert

Diabetes Reversal & Healthy Weight Reduction | 30+ Years of Evidence-Based Success | Led by MIT Scientist & East Asian Medicine Expert | Click the link to Understand Your Blood Sugar ??

9 个月

This is such an insightful piece of content????

Dr. Jake F. Felice

| Flow Therapy | Transformational Advice | End of Life Support | Founder at Sweetwater Holistic LLC | ?? Doctor of Naturopathy ?? | Change Agent | Scholar ??| Teacher | Wave Chaser |

9 个月

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