?????????????????? ???? ?????????? ???????????? ?????????????????? ???????????????????? (????????)
?????????? ???????? ???? ?????????????? ??????:- https://bit.ly/3dlrUpZ
Whole genome bisulfite sequencing is a next-generation sequencing technology used to determine the DNA methylation status of single cytosine's by treating the DNA with sodium bisulfite before high-throughput DNA sequencing.
Whole-genome bisulfite sequencing (WGBS) is a technique used for the analysis of genome-wide DNA methylation patterns (DNA methylomes) at a single-base resolution.
?????? ???????? ?????????? ???????????? ?????????????????? ???????????????????? (????????) ?????????
Recent advances in sequencing techniques have allowed whole genome sequencing to become more common and quicker. Whole genome bisulfite sequencing (WGBS) is one such next generation sequencing technique that allows users to analyze DNA methylation at single base resolution.
DNA methylation is an epigenetic mechanism that regulates gene expression and has applications in several biological fields, such as diseases and cancer.
Advantages of Whole Genome Bisulfite Sequencing
- Highly integrated single-base resolution DNA methylation patterning.
- Providing insights into gene cell-fate commitment and reprogramming, as well as gene regulation.
- Identifying novel epigenetic markers and targets for disease.