February 2024 edition: a highly optimised workflow for proteomic analysis of FFPE tissue samples and more
Check out the latest in proteomics research, including the latest publications featuring IonOpticks' famed Aurora Series products.
LATEST PAPERS
In proteomics, targeted protein degradation (TPD) has emerged as a powerful approach to directly edit the proteome, complementing genetic techniques like CRISPR and siRNA. A recent research paper by Taylor et al. explores the use of human E2 ubiquitin-conjugating enzymes, such as...
This study introduces DIA-ME (Data Independent Acquisition-Matching Enhancer), a novel approach for improving proteome coverage in single-cell proteomics.?The method combines low-input samples with higher-input reference samples during analysis, leveraging...
Insights into extracellular vesicle (EV) protein composition and function during human brain development: Forero et al. investigated EV heterogeneity across different neural cell types and developmental stages, using both 2D neural cultures and 3D...
Haines et al. present a highly optimised workflow for proteomic analysis of formalin-fixed, paraffin-embedded (FFPE) tissue samples, addressing critical challenges in mass spectrometry-based proteomics. The researchers out of the Carr lab developed a partially automated, plate-based approach that enables reproducible...
INDUSTRY
New app note: Orbitrap Astral mass spectrometer allows comprehensive proteome coverage at the single-cell level
The power and performance of Aurora Series columns with Thermo Scientific's Orbitrap Astral is demonstrated once again in this new application note, with proteome profiling at the single-cell level, detecting up to 6,500 protein groups per cell.?An impressive dynamic range spans more than five orders of magnitude with exceptional reproducibility (R=0.93–0.98) - the Aurora Elite C18 column with the Astral delivers outstanding sensitivity and accuracy.
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EVENTS
Find IonOpticks at these upcoming international events:
AUS-oMicS
Cairns, Australia
18-21 May, 2025
8th Single Cell Proteomics Conference (SCP2025)
Boston, USA
27-29 May, 2025
73rd Conference on Mass Spectrometry and Allied Topics (ASMS2025)
Baltimore, USA
1-5 June, 2025
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