Extraction and Standardization of BioJoin Trademark Product for Joint Health and Muscle Strength.

Abstract: Boswellic acids are naturally present in gum extrudes of Boswellia serrate tree. Boswellic acids has promising activity on joint pain and muscle strength. The study aims at developing a more potential product “BioJoin?”, combining Boswellia serrata and Acacia catechu, which provides bone health, immunity support, enhanced mobility and promote joint health and pain relief. Boswellic acid, Catechins, Polyphenols enhanced with required minerals were combined to increase the efficacy of the product and designed into powder form and tablet form for consumption. The Acacia catechu extract was tested with HPLC for the catechin content and found to be not less than 40% and boswellic acid in Boswellia serrata extract was found to be not less than 65% by HPLC. Final Biojoin product was tested for total polyphenol content and was found to contain not less than 15% polyphenols which could provide benefit to the bone health and strength Bone health is important at every age and stage of life. The skeleton is our body's storage bank for several minerals that are necessary for our bodies to function. If we do not have enough minerals in our diets to keep our bodies functioning, this causes our bones to grow weaker and leads to inflammatory responses. Loss of bone strength can lead to several bone disorders in which bones become very fragile and more likely to break. Polyphenols, a class of natural antioxidants, is found in Acacia catechu which belongs to the Fabaceae family. Catechins in Acacia catechu have shown anti-inflammatory effects by modulating inflammatory pathways. These compounds may inhibit the production of pro-inflammatory cytokines and enzymes such as COX-2 (cyclooxygenase-2), 5-LOX (5-lipoxygenase), and TNF-alpha (tumor necrosis factor-alpha), which play a role in chronic inflammation. As such, Acacia catechu extract can potentially alleviate symptoms in inflammatory conditions like arthritis, rheumatoid arthritis, and gout.

Keywords: BioJoin?, Boswellia serrata, Acacia catechu, catechins, boswellic acids, Polyphenols Bone health is important at every age and stage of life. The skeleton is our body's storage bank for several minerals that are necessary for our bodies to function. If we do not have enough minerals in our diets to keep our bodies functioning, this causes our bones to grow weaker and leads to inflammatory responses. Loss of bone strength can lead to several bone disorders in which bones become very fragile and more likely to break. Polyphenols, a class of natural antioxidants, is found in Acacia catechu which belongs to the Fabaceae family. Catechins in Acacia catechu have shown anti-inflammatory effects by modulating inflammatory pathways. These compounds may inhibit the production of pro-inflammatory cytokines and enzymes such as COX-2 (cyclooxygenase-2), 5-LOX (5-lipoxygenase), and TNF-alpha (tumor necrosis factor-alpha), which play a role in chronic inflammation. As such, Acacia catechu extract can potentially alleviate symptoms in inflammatory conditions like arthritis, rheumatoid arthritis, and gout. Boswellic acid is a naturally occurring compound in Boswellia serrata which is also known as Indian frankincense belongs to the Burseraceae family. Boswellia serrata contains various derivatives of boswellic acid including β-boswellic acid, acetyl-β-boswellic acid, 11-keto-β- boswellic acid and acetyl-11-keto-β-boswellic acid.[1].

Extracts of Boswellia serrata have been clinically studied for osteoarthritis and joint function, with the research showing trendsof benefit (slight improvement) in pain and function.[2] The study aims at developing a more potential product “BioJoin?”, combining Boswellia serrata and Acacia catechu, which provides bone health, immunity support, enhanced mobility and promotes joint health and pain relief. Boswellic acid, Catechins, Polyphenols enhanced with required minerals were combined to increase the efficacy of the product and designed into powder form and tablet form for consumption. The Acacia catechu extract was tested with HPLC for the catechin content and found to be not less than 40% and boswellic acid in Boswellia serrata extract was found to be not less than 65% by HPLC. Final Biojoin product was tested for total polyphenol content and was found to contain not less than 15% polyphenols which could provide benefit to the bone health and strength

Keywords: BioJoin?, Boswellia serrata, Acacia catechu, catechins, boswellic acid.