'Extra' chromosome in fruit flies raises hopes of targeted cancer therapies
A team from the Stowers Institute for Medical Research has unfolded the dynamics of a very young chromosome in fruit flies, which is similar to chromosomes in humans and associated with treatment-resistant cancer and infertility. This tiny chromosome, which has been in existence since two decades, has persisted in a single, lab-reared strain of the fruit fly Drosophila melanogaster and has been found to correlate with supernumerary chromosomes in humans.
Supernumerary chromosomes in humans are found in cancer cells. They are known to interfere with drugs intended to target tumors, which makes treatment of cancers like osteosarcoma extremely challenging. Further, their presence in men can disrupt normal chromosome segregation during sperm production, which may lead to infertility.
Comprehending the evolution, structure, and mechanisms of supernumerary chromosomes can potentially bring to light their vulnerabilities which can eventually trigger the development of potential therapeutic targets.
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Presumptive Republican Nominee for Governor of Oregon | Genomics, Neuro & ML Researcher | Father | Farmer | For the Republic ?????? #RedneckRoyalty
5 个月Stowers. I need a secure channel/mechanism to send my PhD thesis. Had to start from scratch again after state agents locked my last backup draft. Havana Syndrome state actors at the National Reconnaissance Office are blocking my uploads, taking over my accounts. One of them has a family member that wants my sequence search algorithm (got onboard after the order of magnitude performance improvement I made right after my viva/defense) and the proof of the concentration of measure phenomenon in pan-transcriptomics to “become someone”. The others are trying to prevent me from running for governor in Oregon given my family’s history here, they don’t want it flipping Republican. An unknown agency saved me from an assissination attempt. They are claiming something to do with National Security to pull this off, but won’t serve me a National Security Letter. If I leave the country they won’t let me back in as at least one person involved controls a national security division of the FBI in Oregon territory. Short rundown. Anyone else that sees these posts, tell the world. Do not let scientists move to America until we take control back from the intelligence community. This is a Second American Revolution and it is happening peacefully.