Exploring the Genetic Landscape of Mycobacterium tuberculosis: Unlocking the Differences in Between Latent and Active Tuberculosis

Exploring the Genetic Landscape of Mycobacterium tuberculosis: Unlocking the Differences in Between Latent and Active Tuberculosis

Parissa Farnia Parissa Farnia

Parissa Farnia

Deputy of Research and Development / Editor of Biomedical and Biotechnology Research Journal, International Journal of Mycobacteriology and Journal of Preventive, Diagnostic and Treatment Strategies in Medicine

发布日期: 2025年1月9日
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By : Velayati, Ali Akbar1; Mitaria, Satoshi 2; Farnia, Parissa1; Farnia, Poopak1; Ghanavi, Jaladein1; Maleknia, Mohsan1; Murase, Yoshiro2; Hoffner, Sven3

1.Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2.Department of Mycobacterium Reference and Research, Research Institute of Tuberculosis, Japan Anti-tuberculosis Association, Kiyose-Shi, Tokyo, Japan

3.Department of Global Public Health, Karolinska Institute, Stockholm, Sweden

This figure shows the detailed genetic and structural analysis of the PPE35 protein, which highlights the effects of a specific frameshift mutation caused by an adenine insertion. This mutation, referred to as the c.1798dupA variant, alters the reading frame of the genetic code, leading to changes in the amino acid sequence, particularly affecting position 600.



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