Evolution in Disintegration Testing

Disintegration testing is a crucial process in pharmaceutical development, ensuring that tablets and capsules break down within a specified time when exposed to liquid, simulating conditions in the human body. This test is essential for verifying the quality and effectiveness of solid dosage forms, influencing drug absorption and bioavailability.

The new?DISI Evo?from?Charles Ischi?represents a leap in disintegration testing technology. Its innovative features include enhanced precision, real-time data monitoring, and improved automation, allowing for seamless integration into modern quality control environments. With its user-friendly interface and high throughput capacity, the Disi Evo ensures more efficient and accurate testing, setting a new standard in the pharmaceutical industry.

DISI Evo – bathless disintegration tester, meticulously engineered for precision, efficiency, and user-friendliness. The device offers a swift solution for disintegration tests, demanding minimal maintenance. Contact and more information

CHARLES ISCHI AG - OSD Testing Technology at CPHI Milan: Booth 6F37 (with BIOGRUND)

What is the difference of a traditional and a bathless tester like Disi Evo?

• Bathless Design: No need of a water bath to maintain the temperature of the disintegration medium at around 37°C (mimicking body temperature), which is circulated around the test vessels.
• Temperature Control: Even heating based on a more direct and precise temperature control, as it heats the medium in each vessel individually. This results in more consistent temperature regulation during the test.
• Maintenance: The bathless design reduces maintenance tasks since there's no water bath to clean or maintain. This can lead to less downtime and easier handling of equipment.
• Speed and Efficiency: The lack of a water bath means faster setup and heating times, making it a more efficient option for labs looking for quicker turnaround in testing
• Footprint and Portability: DISI Evo is more compact and portable because it eliminates the water bath, making it easier to fit into smaller lab spaces or move around as needed.

Key benefits of DISI Evo:

• For tablets and capsules
• User-friendly touch screen operation
• 100% unattended end-point detection for each tablet
• Fully compliant wireless self-centering baskets
• Automatic test start when target temperature has been reached
• Continuous monitoring of medium level and temperature
• Bathless induction heating allows to bring the water to 37 ?C for very short heating times
• Modular up to 4 stations
• The system fulfils the requirements of FDA 21 CFR Part 11 (optional).

Real-time monitoring of the remaining height of the tablets

During each upward stroke of the basket, an automatic height measurement tracks the remaining thickness of the tablets. This feature is especially advantageous for coated tablets and capsules with residual shells—no specialized discs needed. It’s also invaluable for R&D labs seeking detailed insights into tablet disintegration characteristics.

Smart display

Prioritizing user convenience, we’ve streamlined the customer experience to ensure significant time savings in the lab. Our cutting-edge HMI control unit, available as an optional addition, can be conveniently positioned either in front of or on top of the tester. Its high-resolution capacitive display, featuring 1024×600 pixels, delivers sharp contrast and expansive viewing angles, guaranteeing a comfortable and effortless operation.

Data analysis

The data analysis concept is based on the successful PH21 production control Software. All data points are stored and may be traced back to the batch and test number. Tabular and / or graphical reports may be printed for single tests and whole batches. It is also possible to print out summary statistics of several batches.

Contact and more information

CHARLES ISCHI AG - OSD Testing Technology at CPHI Milan: Booth 6F37 (with BIOGRUND)

About Charles Ischi AG

Charles Ischi AG – Testing Technology are a Swiss-based specialist manufacturer of testing equipment for tablets and capsules and in-process control solutions for the pharmaceutical and nutraceutical industry. Supplying testing equipment, specializing in oral solid dosage testing technology for research, development, quality control and in-process control.

From its headquarters in Zuchwil, in the central Swiss canton of Solothurn in the heart of Europe, the company maintains an international sales and service network for Kraemer Elektronik tablet and capsule testing equipment and Charles Ischi solutions, which include a revolutionary In-Process Control (IPC) turnkey add-on solution that can upgrade in-process control tablet testing procedures in-line to all makes and model of tablet press and capsule filling machinery.

Charles Ischi has grown and developed over more than two decades by maintaining a rigorous focus on driving new technology introduction and customized solution to ensure customer satisfaction, excellent sales advice and after sales service support.

The company’s key strength is a committed sales force providing support through its international sales network, with individual customer care, support for installation and qualification, training, service and repair.

Its product focus is on tablet breaking force testers, multiparameter tablet testing systems, capsule weighing systems, disintegration testers and friability testers.

Website https://www.ischi.com

Phone +41 32 621 49 23