EpiGenie Newsletter – September, 2023

Ever get that feeling that you forgot something? Well maybe you did, but it doesn't have to be recent epigenetics research if you scope out our headlines each week.

14 September, 2023?

Just Add HiDRO to Figure Out How Genomes Fold in Single Cells

Water hydrates and is essential for life—for plants, humans, and even fish. So, it’s fitting that a new technique called HiDRO takes high-throughput FISH to the next level to identify factors that help?genomes fold in 3D at high throughput in single cells. ?

11 September, 2023?

An Evolutionary and Epigenetic Tour-de-force Links DNA Methylation and Mammalian Aging

Have you climbed Mount Everest? Recorded a critically acclaimed album?? Written the great American novel??? These life-affirming feats of body and mind pale into insignificance when compared to the evolutionary and epigenetic tour-de-force reported in two recent papers based on mammalian?DNA methylation?datasets of colossal size and importance.

11 September, 2023?

“Dynamite” Study Uses TNT To Destroy Epigenetic Memories in Human iPSCs

While?lingering memories can represent unwelcome guests, destroying them with the power of dynamite may seem like overkill! However, a volatile new study now describes TNT or?transient-na?ve-treatment?as a simple means of ridding human induced pluripotent stem cells (hiPSC) of their?epigenetic?memories and improving their therapeutic potential.

Active Motif CUT&RUN Assay Kit Giveaway!

Detecting Global Levels of 5mC and 5hmC at the Same Time—With Color

Color is exciting and fun—just look at Andy Warhol’s striking silkscreen paintings of Marilyn Monroe. Now, a new method uses bright red and green fluorescence to detect global levels of both methylated and hydroxymethylated cytosine (5mCs and?5hmCs) modifications of genomic DNA in the same straightforward assay, which could lead to easy and inexpensive clinical tests. ?

Bringing in “Young Blood” Persistently and Systemically Slows Epigenetic Aging

Be it a football team, a book club, or an?epigenetics?lab, bringing in “young blood” can seriously improve quality in the short term, but does this effect endure? Now, a?heterochronic parabiosis?study reveals that long-term exposure to young blood induces persistent slowing of?DNA methylation-based?epigenetic aging?and extends healthy lifespans in mice!

Altered Chromatin Accessibility Shows Why Aging Stem Cells Don’t Know if They’re Coming or Going!

Once young and carefree, the passing years creep up on us all and bring so many responsibilities and places to be that we don’t know whether we are coming or going! A busy new study shows that the chromatin accessibility and gene expression alterations that occur during?aging?impact neural stem cells (NSCs) in much the same way, leading these pro-regenerative cells to “lose their way” and lose their proper function.

UPCOMING CONFERENCES

Festival of Genomics & Biodata 2023?| 04 OCT 2023

4th Interventions in Aging Conference?| 11 OCT 2023

ASHG (American Society of Human Genetics)?| 01 NOV 2023

AIChE 2023 Annual Meeting?| 05 NOV 2023

Click?here?to see more upcoming conferences

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