EpiGenie Newsletter - February, 2023

14 February, 2023?

mRNA Shows Its Age and Quiets Down the Immune System with Cap2 Methylation

Wrinkles, gray hair, …?Cap2 methylation?on mRNA? It turns out that these are all signs of aging. Two elegant new methods to show that Cap1 gets slowly modified to Cap2 as mRNAs age. And just like boomers, they want to live the quiet life, calming down the innate immune system to prevent autoimmunity.

7 February, 2023?

One More Reason to Eat Your Wheaties: Your Microbiome and Histone Acetylation

We all know how important it is to eat fiber, whether in the form of fruits and veggies, or even a big bowl of fiber-rich cereal. Now, research from?Ben Garcia’s?lab (WUSTL) gives us one more reason to eat our Wheaties—our gut microbiome needs it to acetylate histones and possibly?ward off diseases like colitis.

7 February, 2023?

Chem-map: A New “GPS” to Pinpoint Where Small Molecules Bind Chromatin

With all the GPS trackers and map apps out there, it’s almost impossible to get lost. But even though we know what a lot of small molecules are doing, we can lose track of exactly where those molecules are. That’s why?Shankar Balasubramanian’s?lab (University of Cambridge) developed Chem-map. Knowing this info could help researchers design even better drugs and imaging probes.

6 February, 2023?

You Aren’t Going Crazy – Losing It at the Epigenetic Level Really Drives Aging!

Information loss can drive us crazy – from ruining a potential?culinary masterpiece?to turning a Lego-building afternoon into a nightmare, but can “losing it” at the?epigenetic level drive aging and turn a young whippersnapper into an old fogey?

30 January, 2023?

Taking “CoRSIV” Writing from Short Notes to “Novel” Epigenetic Findings in Disease Risk

Previously, a perfectly-penned?study?uncovered a type of DNA methylation variation “written” in the genome, which varies from person to person but remains consistent across tissues. Deciphering these “CoRSIV” (correlated regions of systemic interindividual variation) notes supported a deeper understanding of epigenetic variance and the impact on disease, with blood DNA methylation profiles from these regions reflecting the epigenetic roots of disease in harder-to-access organs. In the latest edition of this gripping research, the CoRSIV story has taken a genetic twist with a “novel” finding.

23 January, 2023?

scChIX-seq Brings Double the Fun to Single-Cell Histone Modification Profiling

How do you double your fun? An extra scoop of ice cream, coffee?and?a cake, or the epigenetic delights of single-cell profiling of not one but two histone modifications? In the latter case, the?scChIX-seq?(single-cell chromatin immunocleavage and unmixing sequencing) integrated framework may represent a wise choice for those looking to indulge while still clinging to their New Year’s resolutions!

19 January, 2023?

Our friends and colleagues at Active Motif hosted an online conference focusing on the epigenetics of aging. Missed the live events? No problem. All session recordings are now available here: Chromatin-Con 2023: Epigenetics of Aging Online Conference

16 January, 2023?

eBook: Epigenetics of Aging

Aging and longevity research has moved to the forefront of epigenetics in recent years. From DNA Methylation, to the Exposome and “translational inheritance” we are all avidly interested in this topic. In this eBook we review recent and intriguing research into this topic.

LEARNING CENTER

New to the field and want to get up to speed quick? Take a dive into the Learning Center which contains tons of epigenetics background information, profiles of key epigenetic readers, writers, and erasers, plus a useful an ever expanding compilation of useful tools and databases. Check our these highlighted aricles:?

1. Key Epigenetic Players:?Check out our overview of the key epigenetic modifications that play a big role in gene regulation, development, and disease, as well as the proteins that are responsible for reading, writing, and erasing the epigenome.
2. Epigenetics Tools and Databases (Updated!):?Tools, where would humankind be without them? The EpiGenie team decided to search out and compile a list of the best tools and databases that epigenetics researchers can’t live without.

UPCOMING CONFERENCES

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From Epigenetics to Disease to Therapeutics?| 02 Mar 2023

6th Chromatin and Epigenetics Symposiums?| 02 Mar 2023

Int'l Conference on Chromatin Dynamics & Epigeneitcs?| 06 Mar 2023

Single-Cell Multiomics?| 07 Mar 2023

SoCal Metabolism Symposium?| 10 Mar 2023

Keystone - Epigenetics, Chromatin, Development and Disease?| 12 Mar 2023

Click?here?to see more upcoming conferences

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