Epigenetics Newsletter – October, 2023
Active Motif has teamed up with?EpiGenie?to deliver you the best collection of recent epigenetics news articles and educational resources to ensure that you can stay on top of what’s new in epigenetics research.
Epigenetic Inheritance During DNA Replication: A State Lying Somewhere Between Symmetry and Instability
Emerging research has provided evidence for the critical importance of the inheritance of epigenetic states, whether that be DNA methylation, histone modifications, or even non-coding RNAs. Now, three recent studies focusing on the mechanism involved in passing down this information from parental to daughter cells while they replicate their DNA and divide in vitro provide evidence that the epigenetic inheritance of DNA methylation and histone modification profiles lies in a state somewhere between symmetry and instability.
eBook: RNA & Transcriptomics
In this eBook, we look at some the most recent topics in RNA and transcriptomics, which can be fairly “hot methods” based, with an equal amount of biological discovery gained from great techniques! Download the eBook >>
The Missing LncRNA: How the Gut Microbiome Communicates with their Host to Regulate Metabolism
Bacteria, viruses, and fungi in the mammalian gut microbiome vastly outnumber the cells in the human body; however, the detailed mechanisms these gut-dwelling commensal partners use to communicate with their generous hosts and induce responses represent somewhat of a “missing link” in this research. Now, a new epigenetics-based study shows that we should have been searching for a missing lncRNA! Read more >>
Kacme: A New Histone Modification Couples Methylation and Acetylation to Mark Active Transcription
Some couples seem unlikely, yet somehow, they work (a recent pop star-football player pair comes to mind.). Now, an even more surprising couple—a methyl group and an acetyl group—hanging out together on the very same lysine residues on histone H4s has just been spotted across species and appears to be involved in active transcription. Mind. Blown. Read more >>
5hmC Stands Apart from 5mC Through Single-Cell Multi-omic Methods
Sometimes, you really want to stand out from the crowd. For years, 5-hydroxymethylcytosine (5hmC) has lurked in the shadows, often lumped together with 5-methylcytosine (5mC). However, these modifications have different effects—5mC generally turns down expression and 5hmC ramps it up. Read More >>
[GUIDE] CUT&RUN Complete Guide: Overview, Methods, and Resources
CUT&RUN is a valuable tool for studying chromatin-associated proteins because it is sensitive, specific, and requires fewer cells than ChIP, making it ideal for identifying binding patterns of chromatin-associated proteins such as transcription factors or histone modifications genome-wide. This eBook is a complete resource for CUT&RUN, from the background and novelty of the method, to evaluating when it’s the best choice for your research, including sample data, analysis tips, and resources for further study.
领英推荐
[WEBINAR] Recent Technology Advances in Epigenomics Profiling
In this webinar, Sarah Traynor, Research Scientist at Active Motif compares the popular epigenomic profiling techniques ChIP-Seq, CUT&RUN and CUT&Tag, plus discusses how to select the best one for your research project. Read More >>
[BLOG] RNA and DNA Methylation Crosstalk - Regulating Transposable Elements AND Cell Fate!
Evaluation of transposable element regulation in human embryonic stem cells reveals a critical role for crosstalk between RNA methylation and DNA methylation, both shown to have an impact on aging and cancer. In this article, we take it back to the beginning and recent discoveries on these modifications in stem cells, cell renewal and how this may affect tumorigenicity and multipotency.
[BLOG] Shifting the Paradigm - The Critical Role of Transcription Factor Interactions with RNA
In this article, we focus on some of the new research reports on the critical role of interactions between RNA and most transcription factors in the regulation of gene expression. Read more >>
[PODCAST] Differential Methylated Regions in Autism Spectrum Disorders with Janine La Salle
In this episode of the Epigenetics Podcast, we talked with Janine La Salle from UC Davis about her work on differential methylated regions in autism spectrum disorders. Listen Now >>
[PODCAST] Inheritance of Transcriptional Memory by Mitotic Bookmarking with Sheila Teves
In this episode of the Epigenetics Podcast, we caught up with Sheila Teves from the University of British Columbia to talk about her work on the inheritance of transcriptional memory by mitotic bookmarking. Listen Now >>