Epigenetics Newsletter – March, 2023
Active Motif has teamed up with?EpiGenie?to deliver you the best collection of recent epigenetics news articles and educational resources to ensure that you can stay on top of what’s new in epigenetics research.
Layers make things a lot more interesting—a cake with chocolate, vanilla and strawberry layers is much more decadent than a single-tier vanilla one. This new report has put the icing on the cake, describing how to get multi-layered spatial epigenomic and transcriptomics info at near-single-cell resolution. Read More >>
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With mice with two dads, crystal clear images of dying stars, and the rise of ChatGPT being daily news items, does anything make you “pause for thought” these days? This new study provides insight into an epigenetic enigma surrounding the transcriptional role of a histone modification by reporting how H3K4 methylation loss modulates RNAPII pause-release at gene promoters and transcriptional elongation but not initiation. Read More >>
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Don’t you wish you could just look into the nucleus of a cell and watch what’s happening? With SiTomics you can get very gets close—viewing what modifications are being placed on a particular histone, what proteins bind to it, and where that histone is on the DNA, all in living cells. Read More >>
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The climate crisis and our need to produce less waste have made recycling an everyday concept; however, whether histone proteins “go green” during DNA replication has remained somewhat in doubt. Read More >>
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Some shoppers like to browse several stores, whereas others follow the Amazon approach and want to just visit one place to buy everything on their list. This new method rings up genetic and epigenetic reads down to the single-base level and can even be done with tiny amounts of DNA, such as cell-free DNA (cfDNA), which is useful for prenatal and cancer research. Read More >>
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Catch up on presentations from the Chromatin-Con 2023: Epigenetics Mechanisms – Impact on Aging & Disease Meeting. This was a 3-day, online event featuring talks from international experts focusing on the emerging research into the relationship between epigenetic mechanisms on aging and related disease states. Watch Videos >>
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In this blog, we look at how exposure to these environmental stressors such as endocrine-disrupting chemicals (EDCs) during early development can induce metabolic dysfunction following a metabolic challenge in the adult by reprogramming the epigenome. More evidence of how the exposome of our childhood may set us up to be more vulnerable to metabolic disease later in life. Read More >>
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RAS is one of the most common oncogenes, responsible for 20-30% of all human cancers, with KRAS being responsible for most of these. Current research has mostly focused on targeting KRAS mutants, but it’s only been in the last decade that we’ve seen development of methods to directly inhibit mutant KRAS. Here we provide a look at the history of RAS family proteins in the context of mutations and potentially targets to mitigate their action. Read More >>
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In this episode of the Epigenetics Podcast, we caught up with Paul Shiels from the University of Glasgow to talk about his work on the effects of environmental cues on the epigenome and longevity. Listen Now >>
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In this episode of the Epigenetics Podcast, we caught up with Sarah Kimmins from Université de Montreal to talk about her work on the epigenetics of human sperm cells. Listen Now >>
Epigenetics of Aging eBook
In this eBook, we share insights into key epigenetic alterations and targets which are involved in cell senescence and healthy lifespan. Download free eBook >>
Epigenetics Resources
These amazing resources will help you learn more about epigenetics and stay up to date with what’s new. Learn more >>