Epigenetics Newsletter 2024 - Issue No. 4

Active Motif has teamed up with?EpiGenie?to deliver you the best collection of recent epigenetics news articles and educational resources to ensure that you can stay on top of what’s new in epigenetics research.

Epigenome Editing Modules Team Up to Cut Through Gene Regulatory Chaos

Sometimes an indirect approach can give a direct answer. For example, two recent papers use dCas9 based epigenome editing to cut through gene regulatory mechanisms. No cutting required. These epigenomic editing toolkits use single-cell readouts to provide a clearer story of how our favorite chromatin modifications and enhancers do their jobs. Read More >>

Mitochondrial tRNAs as Epigenetic Memories of Sperm’s Epididymal Road Trip

If Hollywood has taught us anything, it’s that a road trip during our younger years can leave enduring memories that influence our adult lives. Now, a “blockbuster” study reveals that environmental pressures during maturation in the epididymis endow spermatozoa with “epigenetic” memories that influence offspring health via the intergenerational epigenetic inheritance of tRNAs. Read More >>

G4-DNA: How an Unforgettable DNA Structure Regulates Gene Expression and Memory

The Eiffel Tower may live long in the memory, and La Sagrada Familia will be remembered for eons (when they finish it!), but can any structure truly rival DNA? Now, a new study describes how one of DNA’s many unforgettablestructural forms – G-quadruplex DNA (G4-DNA) – helps to regulate the gene expression profiles controlling fear extinction memory. Read More >>

DNA Methylation Differences in Imprinting Control Regions Contribute to Ethnic Disparities in Alzheimer’s Disease Risk

Non-Hispanic Black (NHB) patients have a two-fold higher risk of developing Alzheimer’s disease than non-Hispanic White (NHW) patients for unknown reasons; now, a fascinating epigenetics study reveals the involvement of DNA methylation at imprinting control regions (ICRs). Read More >>

[WEBINAR] Spike-In Methods for ChIP-Seq, ATAC-Seq, CUT&RUN and CUT&Tag - Normalization Controls for Your Assays

In this webinar, Brian Egan, Head of R&D at Active Motif discusses why data normalization is often critical for sequencing-based assays like ChIP-Seq, ATAC-Seq, CUT&RUN and CUT&Tag. The concept behind our suite of Spike-In Controls is covered, as well as how and when to use these tools to obtain the best possible results when analyzing experimental data. Read More >>

[BLOG POST] Epigenetic Changes Can Prompt Tumorigenesis, Even in the Absence of Driver Mutations

A fascinating new study from Université de Montpellier reveals that epigenetic dysregulation, via transient suppression of polycomb-driven transcription, can induce tumorigenesis in?Drosophila?– in the absence of driver mutations! Check out this helpful overview of the work to learn how this may impact our way of thinking about cancer mechanisms and research. Read More >>

[BLOG POST] Parkinsons Disease Described at Single-cell Epigenetic & Transcriptomic Level

Paired transcriptomic and epigenetic analyses in single brain cells has illuminated which cells and what mechanisms are involved in age-related neurodegenerative disorders. Thanks to new research from the Yoshiaki Tanaka lab at Université de Montréal and Yoon-Seong Kim at Rutgers University. We present an overview of how they employed this paired profiling to post-mortem brain samples to explore the mechanisms involved in normal aging and Parkinson's disease development! Read More >>

[eBOOK] Spike-In Normalization: Complete Guide - Overview, Methods, and Resources

With this eBook, you will find a complete resource for normalization of assay data sets – from the background and publication of Spike-In normalization to sample data and comparisons, tools and reagents available, and educational resources for further study. Read More >>

[PODCAST] The Impact of Sequence Variation on Transcription Factor Binding with Sven Heinz

In this episode of the Epigenetics Podcast, we talked with Sven Heinz from the University of California in San Diego about his work on the impact of sequence variation on transcription factor binding affinities and genetic diversity. Listen Now >>

[PODCAST] DNA Replication, Transcription and R-loops with Stephan Hamperl

In this episode of the Epigenetics Podcast, we talked with Dr. Stephan Hamperl from the Helmholtz Zentrum Munich center about his work on how conflicts between transcription, replication, and R-loop formation influence genome stability in human cells. Listen Now >>

Additional Epigenetics Resources

CUT&RUN Complete Guide

This eBook is a complete resource for CUT&RUN, and includes sample data, analysis tips, and resources for further study. Download free guide >>

Epigenetics Resources

These amazing resources will help you learn more about epigenetics and stay up to date with what’s new. Learn more >>

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