Epigenetics Newsletter - February, 2023
For more Epigenetics Resources, visit activemotif.com

Epigenetics Newsletter - February, 2023

Active Motif has teamed up with?EpiGenie?to deliver you the best collection of recent epigenetics news articles and educational resources to ensure that you can stay on top of what’s new in epigenetics research.

Taking “CoRSIV” Writing from Short Notes to “Novel” Epigenetic Findings in Disease Risk

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Previously, a perfectly-penned study uncovered a type of DNA methylation variation “written” in the genome, which varies from person to person but remains consistent across tissues. Deciphering these “CoRSIV” (correlated regions of systemic inter-individual variation) notes supported a deeper understanding of epigenetic variance and the impact on disease, with blood DNA methylation profiles from these regions reflecting the epigenetic roots of disease in harder-to-access organs. In the latest edition of this gripping research, the CoRSIV story has taken a genetic twist with a “novel” finding. Read More >>


You Aren’t Going Crazy – Losing It at the Epigenetic Level Really Drives Aging!

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Information loss can drive us crazy – from ruining a potential culinary masterpiece to turning a Lego-building afternoon into a nightmare, but can “losing it” at the epigenetic level drive aging and turn a young whippersnapper into an old fogey? Read More >>

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Chem-map: A New “GPS” to Pinpoint Where Small Molecules Bind Chromatin

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With all the GPS trackers and map apps out there, it’s almost impossible to get lost. But even though we know what a lot of small molecules are doing, we can lose track of exactly where those molecules are. A newly published method named Chem-map may help researchers design even better drugs and imaging probes. Read More >>

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One More Reason to Eat Your Wheaties: Your Microbiome and Histone Acetylation

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We all know how important it is to eat fiber, whether in the form of fruits and veggies, or even a big bowl of fiber-rich cereal. Now, research gives us one more reason to eat our Wheaties—our gut microbiome needs it to acetylate histones and possibly ward off diseases like colitis. Read More >>

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mRNA Shows Its Age and Quiets Down the Immune System with Cap2 Methylation

Wrinkles, gray hair, … Cap2 methylation on mRNA? It turns out that these are all signs of aging. Two elegant new methods to show that Cap1 gets slowly modified to Cap2 as mRNAs age. And just like boomers, they want to live the quiet life, calming down the innate immune system to prevent autoimmunity.

Read More >>

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[BLOG POST] African Turquoise Killifish - A Colorful Up-and-Coming Model in Aging Research!

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The connection between epigenetics, cell senescence and aging continue to grow. As the field expands, so does the range of organisms we’re finding well-suited for the task. Here we present a roundup of all recent protocols and research concerning the African turquoise killifish and its potential as a model for aging. Read More >>

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[PODCAST] Transcription Elongation Control by the Paf1 Complex with Karen Arndt

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In this episode, we caught up with Karen Arndt from the University of Pittsburgh to talk about her work on transcription elongation control by the Paf1 complex. Listen Now >>

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[PODCAST] The Role of PHF13 in Chromatin and Transcription with Karim-Jean Armache

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In this episode of the Epigenetics Podcast, we caught up with Karim-Jean Armache from New York University - Grossman School of Medicine to talk about his work on the structural analysis of Polycomb Complex Proteins. Listen Now >>


Additional Epigenetics Resources

DNA Methylation eBook

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This free eBook is designed to help explain popular methods and help researchers decide on the best approach for their work.

Topics include:

Global Quantification of DNA Methylation

  • Overview
  • Methods and Comparison
  • Sample Data and Tools to Study Global Quantification
  • Products Available to Study Global DNA Methylation Levels

DNA Methylation Enrichment

  • Overview
  • Methods and Comparison
  • Sample Data and Tools for DNA Enrichment
  • Products & Services for Genome-Wide & Gene-Specific Analysis

Single-Nucleotide Resolution Analysis of DNA Methylation

  • Overview
  • Methods and Comparison
  • Sample Data and Tools for Single-Nucleotide Analysis
  • Products & Services for Single-Nucleotide Resolution 5-mc Analysis

Additional Resources

  • Webinars, Podcasts, and Blogs

Download free eBook >>


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