Epigenetics Newsletter 2024 - Issue No. 6

Active Motif has teamed up with?EpiGenie?to deliver you the best collection of recent epigenetics news articles and educational resources to ensure that you can stay on top of what’s new in epigenetics research.

Chrom-seq Uses ‘Readers’ to See Which RNAs Put Epigenetic Marks on Chromatin

Reading glasses, or “readers,” help you see text and other fine details up close. Inspired by our desire for increased resolution, Chrom-Seq uses histone readers to more clearly see which long noncoding RNAs (lncRNAs) interact with particular histone modifications without the need for highly pure antibodies or crosslinking. Read More >>

Histone Serotonylation: From Boosting Moods to Regulating Brain Tumor Progression

While many know that serotonin impacts mood and emotions, a smattering of studies have found that this neurotransmitter can also modify histones and regulate gene expression. Fascinating new research reveals that histone serotonylation contributes to the regulation of aggressive brain tumors, playing a role in the complex interactions taking place between neuron–tumor signaling, epigenetics, and developmental programs. Read More >>

Keeping up With Epigenetic Clocks: PRC2-Age Index Measures Gains of DNA Methylation Across the Genome

While it may seem like it’s harder to keep up with epigenetic clocks than with the Kardashians, this is one you’re not going to want to miss. Many epigenetic clocks used to assess aging are built on the DNA methylation status of a few CpGs, and it’s unclear how these sites are related to aging. The new PRC2-AgeIndex, a genome-wide marker of gain-of-methylation at CpGs that could monitor aging and the effects of fountain-of-youth anti-aging treatments. Read More >>

CoRSIVs in Cows? Targeting a DNA Methylation Bullseye May Improve Livestock Farming!

Finding informative epigenetic targets in the genome is no easy task; however, previous reports on the discovery of correlated regions of systemic inter-individual variation (or CoRSIVs) in humans –? show that DNA methylation patterns vary between individuals but remain consistent across tissues. Now, this talented team sets its sights on understanding this level of epigenetic variation in cattle to improve livestock farming output. Have they hit a DNA methylation bullseye? Read More >>

[WEBINAR] Spike-In Methods for ChIP-Seq, ATAC-Seq, CUT&RUN and CUT&Tag - Normalization Controls for Your Assays

In this webinar, Brian Egan, Head of R&D at Active Motif discusses why data normalization is often critical for sequencing-based assays like ChIP-Seq, ATAC-Seq, CUT&RUN and CUT&Tag. The concept behind our suite of Spike-In Controls is covered, as well as how and when to use these tools to obtain the best possible results when analyzing experimental data. Read More >>

[BLOG POST] The Power of THEMIS - a cfDNA Methylome and Fragmentome Tool for Early Cancer Detection

Integrating cell-free DNA methylome and fragmentome data into the ensemble THEMIS classifier can improve the early detection of cancer. Why hasn’t this been done before? Our review of this new approach in Nature Communications will get you thinking. Read More >>

[BLOG POST] HiDEF-Seq: Exploring How ssDNA Mutations Get Their Start

Here we present a look at HiDEF-Seq – Hairpin Duplex Enhanced Fidelity sequencing – which reveals alterations to single-strand DNA that can give rise to double-strand DNA mutations. For the DNA Damage crowd! Read More >>

[PODCAST] Gene Expression Control and Intricacies of X-chromosome Inactivation with Claire Rougeulle

In this episode of the Epigenetics Podcast, we talked with Claire Rougeulle from the Epigenetics and Cell Fate Center at Université Paris City on this show to talk about her work on gene expression control, the intricacies of X-chromosome inactivation, and the potential of non-coding RNAs in this process. Listen Now >>

[PODCAST] Stem Cell Transcriptional Regulation in Naive vs. Primed Pluripotency with Christa Buecker

In this episode of the Epigenetics Podcast, we talked with Christa Buecker from the Max Perutz Laboratories in Vienna about her work on transcriptional regulation during early embryonic development. Listen Now >>

Epigenetics Resources

These amazing resources will help you learn more about epigenetics and stay up to date with what’s new. Learn more >>

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