Epigenetics Newsletter 2024 - Issue No. 5

Active Motif has teamed up with?EpiGenie?to deliver you the best collection of recent epigenetics news articles and educational resources to ensure that you can stay on top of what’s new in epigenetics research.

The Epigenetics of Exercise: Acvr1c Improves Learning and Memory

Exercise can boost your mood and improve heart and bone health. Now, a talented team uncovers the epigenetic mechanisms behind another good reason to hit the gym. Working out can help with learning and long-term memory via Acvr1c, a member of the TGF-beta family. Read More >>

PaleoHi-C Makes a “Mammoth” Genome Architecture Discovery

Certain scientific findings may be considered colossal or even epic in scale; however, few compare to a “mammoth” new study describing the three-dimensional genome architecture of preserved cells from a 52,000-year-old animal skin sample thanks to a primeval-sounding yet cutting-edge technique known as PaleoHi-C. Epigenetics research goes pre-historic! Read More >>

Age-related Chromatin Remodeling: Loss of Epigenetic Info or the Hijacking of Maturation?

In this world nothing can be said to be certain, except Spain winning at football and age-related chromatin remodeling! While this remodeling was thought to drive aging via the loss of epigenetic information, new research provides evidence for the “hijacking” of developmental maturation via activator protein 1 (AP-1)-activity as a major player. Read More >>

Attacking Aging with TAC: A TERT Activator Compound

Aching joints and wrinkled skin are an unwelcome part of aging, but in the future, you might be able to avoid arthritis medications and cosmetic procedures by getting a shot of TERT activator compound (TAC). A young-at-heart team identified this small molecule, which increases transcription of a telomerase subunit called TERT. The upshot is that a little TAC leads to more youthful human and mouse cells, as well as adult mice with more spring in their step. Read More >>

A CHARMing Epigenetic Editor Enchants Endogenous DNA Methylation Machinery to Pause Prion Disease

While George Clooney or Cate Blanchett exude a degree of charm, a captivating new epigenetic advance may outdo them both! A new study now describes a compact epigenetic editor known as “CHARM” that engages the cell’s own DNA methylation machinery to stop a fatal neurodegenerative disease in its tracks. Read More >>

cfDNA Methylation Analysis Captures the Double Trouble of Inflammaging!

Analyzing cell-free (cf)DNA methylation from liquid biopsies represents a non-invasive approach to profile various diseases, but what if it could help us understand the devious duo of inflammaging – aging and inflammation? A talented team has dealt with this “double trouble” by applying enzymatic methyl-seq (EM-seq) to evaluate cfDNA methylation patterns. Read More >>

[WEBINAR] Spike-In Methods for ChIP-Seq, ATAC-Seq, CUT&RUN and CUT&Tag - Normalization Controls for Your Assays

In this webinar, Brian Egan, Head of R&D at Active Motif discusses why data normalization is often critical for sequencing-based assays like ChIP-Seq, ATAC-Seq, CUT&RUN and CUT&Tag. The concept behind our suite of Spike-In Controls is covered, as well as how and when to use these tools to obtain the best possible results when analyzing experimental data. Read More >>

[BLOG POST] Modulating m6A Levels with Small-molecule Inhibitors - Why Target RNA Modifications?

The N6-methyladenosine (m6A) internal modification of eukaryotic mRNA significantly impacts RNA metabolism and gene expression and, as such, forms one layer of regulation impacting multiple normal and disease-associated biological processes. The complex interactions between RNA methylases, reader proteins, and RNA demethylases remain incompletely explored, and, as such, a deeper understanding of RNA methylation and the potential development of small-molecule modulators of involved factors holds enormous potential in driving forward research and the development of anti-cancer therapies. Read More >>

[BLOG POST] Epigenetic Drug Screening in Patient-derived Organoids Identifies Potential Treatments for Aggressive Breast Cancer

A general lack of targeted therapies combined with its aggressive nature and subsequent poor prognosis has made the search for effective treatments for triple-negative breast cancer (TNBC) a critically important task. Chemotherapy remains the standard treatment approach for TNBC; however, problems such as treatment resistance and disease recurrence further highlight the need to efficiently identify effective new drug treatments for aggressive breast cancer cases. Read More >>

[PODCAST] Gene Expression Control and Intricacies of X-chromosome Inactivation with Claire Rougeulle

In this episode of the Epigenetics Podcast, we talked with Claire Rougeulle from the Epigenetics and Cell Fate Center at Université Paris City on this show to talk about her work on gene expression control, the intricacies of X-chromosome inactivation, and the potential of non-coding RNAs in this process. Listen Now >>

[PODCAST] Epigenetic Mechanisms in Genome Regulation and Developmental Programming with James Hackett

In this episode of the Epigenetics Podcast, we talked with James Hackett from the EMBL in Rome about his work on epigenetic mechanisms in genome regulation and developmental programming. Listen Now >>

[PODCAST] Advanced Optical Imaging in 3D Nuclear Organization with Lothar Schermelleh

In this episode of the Epigenetics Podcast, we talked with Lothar Schermelleh from the University of Oxford about his work on advanced optical imaging in 3D nuclear organisation. Listen Now >>

Additional Epigenetics Resources

CUT&RUN Complete Guide

This eBook is a complete resource for CUT&RUN, and includes sample data, analysis tips, and resources for further study. Download free guide >>

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