Epigenetics Newsletter 2024 - Issue No. 3
Active Motif has teamed up with?EpiGenie ?to deliver you the best collection of recent epigenetics news articles and educational resources to ensure that you can stay on top of what’s new in epigenetics research.
The Force is Strong with Histone H1.0: How Extracellular Stress Regulates Cell Mechanics through Chromatin Structure
Scientists have longed to use “The Force” – provided by intracellular entities known as midichlorians – to help around the lab; now, an epigenetic alliance reports that an intracellular fibroblast component – Histone H1.0 – uses The Force and orchestrates cell mechanics when facing Sith-like evils such as physical/chemical stressors. The force is strong with histone H1.0!
Non-linear Alterations in DNA Methylation Provides Evidence of Aging in Stages!
Certain concepts – the speed of light, the electron’s charge, or the need to change cell media at the weekend – represent common constants in life. Many add the constant decay associated with the aging process to this list; however, analysis of DNA methylation in the mouse intestine now reveals that the aging process may not be as “linear” as once thought and that we may age in stages!
Epigenetics Alone Can Drive Cancer—No Mutations Needed
Epigenetics has moved into the driver’s seat. In a first-of-its-kind study, a talented team show that knocking down polycomb group proteins in Drosophila causes tumors to form, and bringing the proteins back doesn’t fix it. The finding demonstrates that transient epigenetic changes can irreversibly drive cancer—without genetic mutations.
DNA methylation, whether in cells or in a cell-free environment, is one of the most powerful and most studied epigenetic regulators of gene expression and genomic organization. Here we take a look at some particularly interesting recent publications on both the new mechanisms and new methods being reported in this field. Read More >>
G4-DNA: How an Unforgettable DNA Structure Regulates Gene Expression and Memory
The Eiffel Tower may live long in the memory, and La Sagrada Familia will be remembered for eons (when they finish it!), but can any structure truly rival DNA? Now, a new study describes how one of DNA’s many unforgettablestructural forms – G-quadruplex DNA (G4-DNA) – helps to regulate the gene expression profiles controlling fear extinction memory. Read More >>
DNA Methylation Differences in Imprinting Control Regions Contribute to Ethnic Disparities in Alzheimer’s Disease Risk
Non-Hispanic Black (NHB) patients have a two-fold higher risk of developing Alzheimer’s disease than non-Hispanic White (NHW) patients for unknown reasons; now, a fascinating epigenetics study reveals the involvement of DNA methylation at imprinting control regions (ICRs). Read More >>
[WEBINAR] Spike-In Methods for ChIP-Seq, ATAC-Seq, CUT&RUN and CUT&Tag - Normalization Controls for Your Assays
In this webinar, Brian Egan, Head of R&D at Active Motif discusses why data normalization is often critical for sequencing-based assays like ChIP-Seq, ATAC-Seq, CUT&RUN and CUT&Tag. The concept behind our suite of Spike-In Controls is covered, as well as how and when to use these tools to obtain the best possible results when analyzing experimental data. Watch the Video >>
[BLOG POST] Multiomic Analysis of Stem Cell-derived Organoids
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The analysis of transcriptional and chromatin accessibility profiles during the differentiation of human stem cell-derived kidney organoids provides a deeper understanding of organogenesis. We take a look at research from Washington University and MRC Laboratory in the UK, using single-nucleus ATAC-Seq and RNA-Seq to reveal the vast potential of stem cell-derived kidney organoids in understanding the gene regulatory networks controlling kidney organogenesis. Read all about both studies here! Read More >>
[BLOG POST] Calling Cards Technology Improved by Barcoded, Self-Reporting Transposons
Researchers from Washington University recently reported barcoded self-reporting transposon “Calling Cards” technology as an improved means to detect transcription factor binding sites. In this blog, get a concise overview of the method and how this advance supports improved exploration of transcription factor binding in parallel with gene expression changes. Read More >>
[BLOG POST] "Hit-and-Run" Epigenome Editing: An Exciting New Means of Reducing Cholesterol?
Researchers led by Angelo Lombardo at the San Raffaele Scientific Institute report a safe and durable hit-and-run epigenome editing technology that epigenetically silences gene expression to reduce cholesterol levels! Read More >>
[eBOOK] Spike-In Normalization: Complete Guide - Overview, Methods, and Resources
With this eBook, you will find a complete resource for normalization of assay data sets – from the background and publication of Spike-In normalization to sample data and comparisons, tools and reagents available, and educational resources for further study. Read More >>
[PODCAST] The Impact of Sequence Variation on Transcription Factor Binding with Sven Heinz
In this episode of the Epigenetics Podcast, we talked with Sven Heinz from the University of California in San Diego about his work on the impact of sequence variation on transcription factor binding affinities and genetic diversity.
[PODCAST] Using Single-Cell Multiomics to Characterize Human Developmental Hematopoiesis with Ana Cvejic
In this episode of the Epigenetics Podcast, we talked with Ana Cvejic from the Biotech Research & Innovation Centre at the University of Copenhagen about her work on using sc-multiomics to characterize human developmental hematopoiesis. Listen Now >>
Additional Epigenetics Resources
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