Embracing Innovation: The Evolving Role of Synthetic Organic Chemistry in Medicinal Chemistry: Insights, Perspectives and How African Institutions Can

The landscape of chemistry is continually evolving, reshaping the skills required for success in the field. We are witnessing a transition from traditional synthetic organic chemistry towards a fusion we term "AI-BiopharmacoChemistry." Nonetheless, a profound understanding of synthetic organic chemistry remains imperative in drug discovery. However, in the context of the medicinal chemistry profession, these are my opinions.

AI-BiopharmacoChemistry integrates artificial intelligence, biological understanding, and pharmacokinetics to pioneer new drug candidates. Excelling in this domain demands not only proficiency in chemistry but also a deep understanding of AI, biology, and pharmacokinetics.

Recognizing this paradigm shift, we advocate for reforms in our education system, particularly in Chemistry and related disciplines. We propose the introduction of specialized courses to empower students with the multifaceted expertise demanded by modern chemistry.

These courses, potentially offered as audit or credit options, should be tailored to complement existing curricula. Here are some suggestions for such specialized courses:

1. Medicinal Chemistry 101

2. Fundamentals of Pharmacokinetics for Chemists

3. Biochemistry for Chemists

4. AI in Drug Discovery for Chemists

5. Carbohydrate Chemistry, Peptide Chemistry, Chemistry of Lipids and LNP

While some of these above mentioned suggestions may already be underway, there is room for refinement to ensure these courses meet the evolving needs of aspiring chemists. By embracing interdisciplinary education, we can equip the next generation of chemists with the diverse skill set needed to drive innovation and address complex challenges in drug development.

Africa Life Sciences Network