The eazyplex? Gram-negative set for basic diagnostics and for rare resistances

Resistance to antibiotics in Gram-negative pathogens is nothing new. Nevertheless, there is a need for tests not only for common resistances such as KPC, NDM and CTX-M, but also for resistance genes, such as GIM and GES or AmpC, which are still rare at the moment, in order to ensure a complete diagnosis. For this we have developed the eazyplex? SuperBug series for you. See the published references at the foot this document..

The eazyplex? Gram-negative sets detect these resistant genes;

NDM VIM KPC OXA-48 OXA-23 OXA-40 OXA-58 OXA-181

IMP IMI GES GIM CTX-M-1 Group CTX-M-9 Group

A. baumannii OXA-51 ACC CMY-II DHA MOX

These 19 resistant genes are presented in 8 combinations available in the Amplex eazyplex? format. To view the combinations check https://www.eazyplex.com/en-gb/resistenzen-bei-gram-negativen

Common Features of these eazyplex? products;

Lyophilized reagents ? 5 minute sample pretreatment ? No DNA extraction ? Variable device selection ? Real-Time detection ? CE IVD

eazyplex? SuperBug CRE

eazyplex? SuperBug CRE is a molecular biological rapid test for the detection of carbapenemases-producing bacteria from the following samples:

colonies from culture plates. positive blood cultures. directly from the swab. directly from a urine sample.

Kit A, B or C parameters:

The carbapenemases detected by the eazyplex? SuperBug complete tests are listed in the table

eazyplex? SuperBug expert

Resistance to antibiotics in Gram-negative pathogens is nothing new. Nevertheless, there is a need for tests for resistance genes, which are currently still unusual, in order to ensure a complete diagnosis. With eazyplex? SuperBug expert you can also detect the rare carbapenemases IMP, IMI, GES and GIM quickly and reliably in just 20 minutes.

eazyplex? SuperBug AmpC

You can differentiate the following AmpC groups as culture confirmation within 15 minutes with the eazyplex? SuperBug AmpC:

ACC, CMY II, DHA MOX

eazyplex? SuperBug Acineto

Fight against the global threat - MDR A. baumannii!

With the eazyplex? SuperBug Acineto you can detect the OXA variants (OXA-51, OXA-23 -, - 40 and -58-like) and NDM in just 15 minutes.

The majority of A. baumannii forms various OXA carbapenemases (OXA-58 type, OXA-24 type, OXA-23 type) which occur chromosomally encoded or plasmid encoded within the species or can be exchanged between different Acinetobacterspecies. The OXA-51 type chromosomally encoded carbapenemases present in all A. baumannii can also contribute to 1 carbapenem resistance...“

With the eazyplex? SuperBug Acineto you can detect all these relevant OXA types

OXA51 OXA-23 OXA-40 OXA-58 like NDM

in just 15 minutes

The eazyplex? test system is based on a freeze dried, ready to use amplification reaction and can be stored direct at the workplace.

During the amplification the result is shown in Real-Time. TAT from one of the eazyplex readers such as eazyMini.

When you invest in eazyMini you open the door to a wide range of pathogens with TATs below 30 minutes!

Published references

Rapid detection of plasmid-mediated AmpC-producers by eazyplex? SuperBug AmpC assay compared to whole-genome sequencing Journal of Microbiological Methods

Volume 221, June 2024, 106938

Screening of Klebsiella pneumoniae Isolates for Carbapenemase and Hypervirulence-Associated Genes by Combining the Eazyplex? Superbug CRE and hvKp Assays

Antibiotics 2023, 12(6), 959; https://doi.org/10.3390/antibiotics12060959

The Evaluation of Eazyplex? SuperBug CRE Assay Usefulness for the Detection of ESBLs and Carbapenemases Genes Directly from Urine Samples and Positive Blood Cultures

Antibiotics 2022, 11(2), 138; https://doi.org/10.3390/antibiotics11020138

Evaluation of the Amplex eazyplex? SuperBug Acineto test for detection of acquired OXA and NDM carbapenemases in Acinetobacter spp

J Glob Antimicrob Resist. 2021 Mar:24:340-341.doi: 10.1016/j.jgar.2021.01.019.Epub 2021 Feb 8.

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#pathogens #AMR #OXA #ESBL #research #eazyplex #carbapenemases #AmpC #Acinito