Digestive Aging?: Staying Young from the Inside Out

In the pursuit of healthy aging, consumers are increasingly recognizing the significance of maintaining a youthful digestive system. Aging encompasses more than just the passage of time; it reflects the culmination of lifestyle choices impacting various bodily functions.1-2 At Kemin, we are compelled by curiosity to explore the intricate dynamics of digestive aging and offer solutions to support optimal health.

What is Digestive Aging??

As we age, some signs are obvious like finding some gray hairs for the first time or feeling some added aches and pains that weren’t there a few years ago. But just as the skin reflects a lifetime of sun exposure, the culmination of years of effects from diet and other lifestyle choices increases the risk of something going awry in the digestive system.3-6?The gut and its components, including the intestinal barrier, resident immune cells, and microbiome, are important not only to one’s overall health, but to the rate at which one ages.2,3,4,7,8

The Role of the Gut in Healthy Aging

The gut is often overlooked in discussions of aging but it plays a pivotal role in overall health. When we eat food, we are introducing external things into our bodies. ?As the body's primary interface with the external environment, the gut's integrity directly influences nutrient absorption, immune function, and even cognitive health.35 However, over time, factors such as diet, medication use, and aging itself can disrupt the delicate balance of the gut ecosystem, leading to a phenomenon known as gut dysbiosis.36

Understanding Gut Dysbiosis

Gut dysbiosis, characterized by an imbalance in the gut microbiome, is emerging as a key hallmark of aging.2?This imbalance not only compromises digestive health but also intensifies systemic inflammation and weakens immune responses, contributing to a host of age-related ailments.4?Recognizing the importance of addressing gut dysbiosis, researchers are exploring innovative strategies to promote healthy aging from within.

Supporting Healthy Digestive Aging with Kemin

Kemin offers science-backed ingredients shown to support areas affected by digestive aging, including:

ButiShield?: An encapsulated form of calcium butyrate providing a controlled release of butyric acid to support gut health.34 Studies have demonstrated its efficacy in bolstering intestinal barrier function and maintaining a healthy gut environment.9-13

BetaVia?:?Algae-sourced beta 1,3 glucans that help to prime key immune cells, shape the microbiome, and protect intestinal barrier integrity. By modulating immune responses and promoting microbiome diversity, BetaVia? offers comprehensive support for digestive health.14-33

Conclusion?

At Kemin, we remain committed to understanding digestive aging and providing innovative solutions to support lifelong wellness. With our expertise and cutting-edge ingredients like ButiShield? and BetaVia?, we invite formulators to join us in shaping the future of digestive health supplementation.

Explore how Kemin's digestive health solutions can elevate your product offerings and meet the evolving needs of health-conscious consumers.?

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This web page and its associated brochures and other documents do not constitute or provide scientific or medical advice, diagnosis, or treatment and are distributed without warranty of any kind, either expressly or implied. This web page, its title or contents and associated brochures and other documents do not in any way make recommendations for health or marketing claims by the reader. Country and region specific regulations should be considered in this regard. Each claim or statement about the effectiveness of Kemin products and/or each claim or statement comparing the effectiveness of Kemin products to the effectiveness of other products is expressly limited to the United States, unless otherwise disclosed on the Kemin websites.

References:

1. López-Otín, C., et al., The hallmarks of aging. Cell, 2013. 153(6): p. 1194-217.
2. López-Otín, C., et al., Hallmarks of aging: An expanding universe. Cell, 2023. 186(2): p. 243-278
3. Badal, V.D., et al., The Gut Microbiome, Aging, and Longevity: A Systematic Review. Nutrients, 2020. 12(12).
4. Ghosh, T.S., F. Shanahan, and P.W. O’Toole, The gut microbiome as a modulator of healthy ageing. Nat Rev Gastroenterol Hepatol, 2022. 19(9): p. 565-584.
5. Nagpal, R., et al., Gut microbiome and aging: Physiological and mechanistic insights. Nutr Healthy Aging, 2018. 4(4): p. 267-285.
6. GI-Society. Aging Digestive Tract. Gastrointestinal Society A-Z Digestive Topics 2020 [cited 2024 January 16]; Available from: https://badgut.org/information-centre/a-z-digestive-topics/aging-digestive-tract/
7. Luís, C., et al., Nutritional senolytics and senomorphics: Implications to immune cells metabolism and aging - from theory to practice. Front Nutr, 2022. 9: p. 958563.
8. de Vos, W.M., et al., Gut microbiome and health: mechanistic insights. Gut, 2022. 71(5): p. 1020-1032.
9. Banasiewicz T, Domagalska D, Borycka-Kiciak K, Rydzewska G. Determination of butyric acid dosage based on clinical and experimental studies – a literature review. Gastroenterology Review/Przegl?d Gastroenterologiczny. 2020;15(2):119-125. doi:10.5114/pg.2020.95556.
10. Donohoe, D.R., Garge, N., Zhang, X., Sun, W., O'Connell, T.M., Bunger, M.K. and Bultman, S.J., 2011. The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. Cell metabolism, 13(5), pp.517-526.
11. Yan, H. and Ajuwon, K.M., 2017. Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway.?PloS one,?12(6), p.e0179586.
12. Peng, L., Li, Z.R., Green, R.S., Holzman, I.R. and Lin, J., 2009. Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers.?The Journal of nutrition,?139(9), pp.1619-1625.
13. Bach Knudsen, K.E., L?rke, H.N., Hedemann, M.S., Nielsen, T.S., Ingerslev, A.K., Gundelund Nielsen, D.S., Theil, P.K., Purup, S., Hald, S., Schioldan, A.G. and Marco, M.L., 2018. Impact of diet-modulated butyrate production on intestinal barrier function and inflammation. Nutrients, 10(10), p.1499.
14. Salminen, et al. Nat rev Gastroenterol Hepatol (2022). https://www.nature.com/articles/s41575-021-00440-6
15. Evans, M., et al., Effect of a Euglena gracilis Fermentate on Immune Function in Healthy, Active Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.? Nutrients, 2019, 11(12), 2926
16. Kemin, BetaVia Complete can prime key cells in the innate immune system. KHTL-017-150.
17. KHTL-017-162 BetaVia Pure Can Prime Key Cell sin the Innate Immune system. KHTL-017-150.
18. KHTL-017-160 Paramylon Improves Antioxidant Status and Metabolic Health-TL-20-18529
19. KHTL-017-149 Characteristics and Prebiotic like Properties of BetaVia Complete
20. Kemin, Characteristics and prebiotic like properties of BetaVia Complete. KHTL-017-149.
21. Bhattad T, Koradiya A, Prakash G. Prebiotic activity of paramylon isolated from heterotrophically grown Euglena gracilis. Heliyon. 2022 Aug 27;7 (9): e07884. doi: 10.1016/j.heliyon.2022.e07884
22. Russo, R., et al. “Euglena gracilis paramylon activates human lymphocytes by upregulating pro-inflammatory factors.” Food Science & Nutrition 5.2 (2017): 205-214
23. Kondo, Y., et al. "Cytokine-related immunopotentiating activities of Paramylon, a β-(1→ 3)-D-glucan from Euglena gracilis." Journal of Pharmacobio-dynamics 15.11 (1992): 617-621.
24. Kankkunen, P., et al. "(1, 3)-β-Glucans activate both dectin-1 and NLRP3 inflammasome in human macrophages." The Journal of Immunology 184.11 (2010): 6335-6342
25. Brown, G.D., and Siamon G. Immune recognition: A new receptor for [beta]-glucans." Nature 413.6851 (2001): 36.
26. Brown, G.D., et al. "Dectin-1 is a major β-glucan receptor on macrophages. Journal of Experimental Medicine 196.3 (2002): 407-412.
27. Brown, G.D., et al. Dectin-1 mediates the biological effects of β-glucans." Journal of Experimental medicine 197.9 (2003): 1119-1124.
28. Goodridge, H.S. et al. "β‐glucan recognition by the innate immune system. Immunological reviews 230.1 (2009): 38-50.
29. KEMIN internal document: SD-18-00083
30. Ishibashi, Ken-ichi, et al. “Effects of Euglena gracilis EOD-1 ingestion on salivary IgA reactivity and health-related quality of life in humans.” Nutrients 11.5 (2019): 1144.
31. Nakashima, Ayaka, et al. “The alga Euglena gracilis stimulates Faecalibacterium in the gut and contributes to increased defecation.” Scientific reports 11.1 (2021): 1-8.
32. Nakashima, Ayaka, et al. “Effects of Euglena gracilis Intake on Mood and Autonomic Activity under Mental Workload, and Subjective Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled Trial.” Nutrients 12.11 (2020): 3243.
33. Kawano, Takanori, et al. “Effect of Food Containing Paramylon Derived from Euglena gracilis EOD-1 on Fatigue in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trail.” Nutrients 12.10 (2020): 3098.
34. ?KHTL-017-183
35. González Olmo BM, Butler MJ, Barrientos RM. Evolution of the Human Diet and Its Impact on Gut Microbiota, Immune Responses, and Brain Health. Nutrients. 2021 Jan 10;13(1):196. doi: 10.3390/nu13010196. PMID: 33435203; PMCID: PMC7826636.
36. Anand N, Gorantla VR, Chidambaram SB. The Role of Gut Dysbiosis in the Pathophysiology of Neuropsychiatric Disorders.?Cells. 2023; 12(1):54. https://doi.org/10.3390/cells12010054