DIAGNOSIS AND MANAGEMENT OF FUNGAL INFECTIONS IN SOLID ORGAN TRANSPLANT RECIPIENTS IN SOUTH ASIA

Solid organ transplant (SOT) recipients frequently contract fungi infections. Invasive fungal infections (IFI) are the third most frequent cause of infections in SOT recipients in South Asia. IFI are a substantial source of morbidity and mortality in this population.?

Numerous problems, including lack of knowledge, poor physician training, inadequate laboratory assistance for infection diagnosis, and occasionally an absence of suitable antifungal drugs to treat infections, contribute to the poor outcomes of these patients.?

In India, invasive candidiasis is the most prevalent IFI, followed by invasive aspergillosis, mucormycosis, and cryptococcosis. Azole resistance and multi-drug resistance are becoming more common among candida infections in South Asia.?

When treating various fungal infections, it is important to keep in mind that azoles and tacrolimus, cyclosporine, and everolimus have medication interactions. Additional challenges include evaluation and providing care for donors and recipients before and after organ transplantation.

Finally, by raising awareness among transplant doctors, expanding access to better diagnostic tools, and using appropriate antifungal medications to treat these infections, the outcomes of these patients can be improved.

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