Cystoscopy-like procedure for prostate examination? Do we need a paradigm shift?
Serge Grabtchak, Ph.D.
Founder and President at HalTecHub Consulting I Entrepreneur I Scientist
"Cystoscopy is endoscopy of the urinary bladder via the urethra. It is carried out with a cystoscope. The urethra is the tube that carries urine from the bladder to the outside of the body. The cystoscope has lenses like a telescope or microscope." (Wikipedia)
How about using a similar procedure for prostate endoscopy? For what purpose? Prostate health monitoring and catching early stages of PC. It's my understanding that cystoscopy is not performed on a routine basis like DRE. And there is a reason for it - it's more invasive, may give more possible side effects and it's usually performed under local anaesthesia. So, men feel it and.. hate it. They can be more acceptive of X-core prostate biopsy with multi-core brachytherapy done under general anaesthesia with an assertion from a radiation oncologist that urethra will stay untouched!
If PC can be detected via a cystoscopy-like procedure under local anaesthesia without using the cavalry like PET/CT, MRI would it be of any practical value? Also, how practical would be to perform such a procedure say, yearly for a prostate check up?
I should have been more clear on a "cystoscopy-like procedure". The endoscope is modified for prostate applications. Instead of inspecting superficial tissues as in the bladder, it collects diffuse light from the entire prostate that has been illuminated via rectum. That's where the second probe, i.e. TRUS with an integrated light source is inserted. The endoscope in the urethra has angular selective detection window that can scan the prostate in the entire 360-deg. Collected data produce not an image per se but a spectro-angular map of light distribution in the gland. It is decomposed to contribution of major chromophores: Hb, HbO2, H2O. A presence of cancer drives a total concentration of Hb up and at the same time oxygenation (HbO2) goes down. I did such studies on ex vivo canine prostate.
Please note that this is a (male) scientist talking:)
Medical Epidemiologist/DPO. Passion for public health since 2001. An anthophile & fruitarian
9 年Great post and thinking. I liked the last sentence