Cutaneous Melanoma: An Overview of Physiological and Therapeutic Aspects and Biotechnological Use of Serine Protease Inhibitors

Check out our latest publication Check out our latest publication in Molecules (https://www.mdpi.com/1420-3049/29/16/3891). In this piece, we address the incidence of melanoma worldwide and its staging phases. We thoroughly investigate the di?erent melanomas and their associated risk factors. In addition, we underscore the principal therapeutic goals and pharmacological methods that are currently used in the treatment of melanoma.

Huge congratulations to our fantastic collaborators at Maria Luiza Vilela Oliva (Unifesp) and Durvanei Augusto Maria (Instituto Butantan)

based?on?tumor?thickness?and?substage?in?the?presence?of?ulceration?(stages?I?and?II).?Patients?with?lymph?node?metastases?(stage?III),?the?clinical?status?of?the?lymph?nodes?(palpable?or?not),?and?the?number?of?metastatic?lymph?nodes?are?the?main?prognostic?factors.?Stage?IV?melanoma?is?characterized?by?the?spread?of?cancer?beyond?the?skin?and?regional?lymph?nodes,?reaching?distant?organs?and?tissues,?through?distant?metastases.?At?this?advanced?stage,?melanoma?can?spread?to?the?liver,?lungs,?brain,?bones,?or?other?organs,?which?signi?cantly?increases?the?complexity?of?treatment?and?associated?complications.?Stage?IV?is?generally?considered?to?be?an?advanced?disease?stage,?with?a?signi?cant?impact?on?prognosis?and?therapeutic?options.?(A)?In??rst?stage,?the?tumor?is?thin?and?less?than?1?mm?thick.?(B)?In?stage?II,?the?tumor?is?between?1?and?2?mm?thick.?(C)?Presence?of?lymph?node?metastases.?(D)?Distant?metastases?are?present.?This??gure?was?created?with?BioRender.