Current trends in drug delivery and excipients in the pharmaceutical industry

An outlook on the importance of excipients by pharmaexcipients which will also be part of the upcoming ExciPerience Event - March 9 & 10, 2022

Excipients play a crucial role to achieve a drug product and drug delivery profile. With the changes in production options and improvements such as continuous manufacturing and 3Dprinting as well as enabling new therapies like oral delivery of large molecules and precision medicine the role of excipients from “non-active” ingredient in a formulation has changed to increased functionality and designed for purpose.

A better understanding of the excipients, impact of variabilities on production process, yield??and final drug product is fundamental and needs to be addressed. In-Silico, predictive development and artificial intelligence can support the “right first time approach” which can lead to faster and more successful drug product development and lead the industry in the needed direction.?

Quality by Design approaches are nowadays standard in the industry but still very focused on the critical process parameters and less on the impact of excipient variations based on the source inherent variabilities due to the nature of the excipient or other factors.

ExciPerience March 9 & 10, 2022 will cover several of these important topics, experts share their valuable insights and discussions will be fostered throughout the event.

Manufacturing Technologies -??3Dprinting, Continuous Manufacturing

• Keynote:?"How 3D printing is changing medicine", by Prof.?Joseph DeSimone.?
• "Application of lipids in challenging processes: Spray-drying and 3D printing",?Dr?Sharareh Salar-Behzadi
• "Formulation trends, including Continuous Manufacturing tableting",?Dr Maj-Britt Cepok

In-Silico / Predictive Development and artificial Intelligence

• "In-silico polymer screenings for rational amorphous solid dispersion development", Dr Christian Lübbert
• "Numerical methods in the design of solid pharmaceutical formulations: state of the art, and future challenges", Dr Maxim Puchkov
• "Opportunity and challenge of artificial intelligence (AI) in drug delivery",?Prof. Defang Ouyang

Gender impact and special patient groups

• “Tumor neurons and patient sex affect nanomedicine efficacy”, Prof. Avi Schroeder
• "Formulations for infants and young children: Innovative use of excipients in film coating", Dr Fang Liu
• "Sex matters: Excipients actively modulate drug response differently in males and females", Christine Madla, PhD

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Excipient Variability and QbD

• ?"Biopharmaceutical Implications of?Excipient Variability on Drug Solubility and?Dissolution",?Dr Nikoletta Fotaki
• "Early Phase Pharmaceutical Product Development using Quality by Design tools", Prof. Walkiria Schlindwein

Excipient Registration

"The complexities of Excipient?Registration in China and potential?solutions", Dave Schoneker

and more to be announced shortly...

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