CSF Neurofilament light chain (NfL) increase precedes clinical worsening in MS

In this study, CSF NfL is significantly elevated and precedes clinical symptoms by many weeks.

CSF NfL increase correlates with clinical symptoms despite no change in MRI suggesting more sensitive and relevant biomarker for a relapse than MRI.

CSF NfL returns to baseline consistent with clinical improvement.

This is unlikely to be popular in practice but if serum NfL will be found to have the same correlation, the new tool can help in predicting clinical relapses.