CRP for Diagnosis/Classification of Inflammatory Diseases and Infection

Human C-reactive protein (CRP) is one of the so-called acute phase proteins. Its concentration in blood increases rapidly after a single systemic stimulus.

As shown in the image above, CRP is a pentamer with a total mass is approximately 120 kDa. The molecule is routinely used as a non-specific marker of inflammation. In plasma the half-life of CRP is about 19 hours and is constant under all health and disease conditions. The concentration of circulating CRP, produced in the liver, is solely dependent on the synthesis rate, which directly reflects the intensity of the pathological processes stimulating the CRP production.

Advanced ImmunoChemical offers recombinant human CRP antigen expressed in mammalian cells and purified under native conditions that excludes renaturation steps. Recombinant human CRP is immunochemically active in different sandwich immunoassay pairs using our antibodies (Figure 1).

Figure 1.?Calibration curve A: for the recombinant human CRP .? Calibration curve B: obtained with monoclonal antibodies (capture-detection) CRP30cc-CRP135cc and with C2cc-C4cc sandwich immunoassays.

Elevated CRP-levels can be seen in diseases described below in Table 1. The routine clinical use of CRP measurement includes: screening test for organic diseases, assessment of disease activity in inflammatory conditions, diagnosis and management of infections, and differential diagnosis or classification of inflammatory disease.

Table 1. Major acute-phase CRP Responses

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Anne Tolles, M.Sc./Pres.