Crohn’s vs Ulcerative Colitis — What Are the Key Differences?
According to the Centers for Disease Control, around 3.1 million adults (1.3%) have?inflammatory bowel disease?in the United States. Despite the fact that it affects so many Americans, there’s still confusion around two different types of IBD—Ulcerative Colitis and Crohn’s disease. Although these diseases share similarities, they are not the same.?
Sometimes it can be hard to tell Crohn’s and Ulcerative Colitis disease apart at first glance. However, there are notable contrasts in symptoms and treatments between the two diseases. They also affect different areas and depths of the digestive tract, leading to unique complications.?
If you have IBD, understanding the differences between Ulcerative Colitis vs. Crohn’s is important. This blog post will dive deeper into their five key differences and explore treatment options.
Where Is the Inflammation Located?
In both Crohn’s and?ulcerative colitis, the inflammation affects the gastrointestinal tract. However, a key difference between these diseases is the?precise?location of the inflammation.?
Crohn’s disease can occur anywhere along the gastrointestinal tract, which goes from the mouth to the anus. “Skip lesions” are common, where areas of disease are dispersed throughout the healthy tissue of the GI tract. In most cases, Crohn’s affects the portion of the small intestine that meets the large intestine.?
On the other hand, ulcerative colitis specifically affects the colon and rectum. Depending on where the inflammation is located, there are different subsets of UC, like ulcerative proctitis or pancolitis.
The patient’s symptoms are the first indication of an inflammatory bowel disease. If a doctor suspects IBD, they first use blood tests to rule out other diseases, identify nutrient absorption issues, and signify inflammation. Stool samples can also indicate if high levels of inflammation are present.
For a proper IBD diagnosis, doctors primarily use imaging techniques like MRI, CT scans, colonoscopies, and capsule endoscopies. The pattern of disease (location and depth of inflammation) can often help differentiate between these two conditions.
Affected Layers of the Gastrointestinal Tract
The gastrointestinal tract wall consists of four layers:
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Crohn’s involves inflammation that extends through the entire thickness of the intestinal wall—from the innermost mucosa to the outermost serosa. This deep inflammation causes a range of complications. Fistulas, or abnormal connections between the intestine and organs, may form. They oftentimes result in swollen and painful infections called abscesses.?
Additionally, inflammation and scar tissue can cause the intestines to swell and lead to blockages called strictures, which are relatively common for those diagnosed with Crohn’s disease. A 2010 study determined that 18.6% of patients with Crohn’s experienced?structuring complications?90 days after their diagnosis. Another 50% had complications after 20 years.?
In contrast, ulcerative colitis primarily affects the innermost lining of the colon and rectum, called the mucosa. Chronic inflammation can cause ulcers that bleed–and rectal bleeding is very common for ulcerative colitis patients. They may also experience a toxic megacolon, which is a rare but dangerous complication.
Symptom Patterns
Although the two conditions do present with similar symptoms (abdominal pain, diarrhea,?weight loss, and fatigue), there are patterns that separate Ulcerative Colitis from Crohn’s disease.
For the most part, the symptoms of ulcerative colitis build over time. It usually begins to present itself with painful diarrhea that contains blood or pus. Since the disease mainly affects the rectum and colon, patients often experience rectal pain and bleeding. It’s also marked by the inability to defecate, despite having a strong urge to do so.
Like ulcerative colitis, Crohn’s disease symptoms often develop gradually. Some of the notable symptoms of Crohn’s include mouth sores, blood in stool, or painful leaking near the anus because of fistulas. Symptoms can also present in other areas, like the eyes, skin, and joints.
The symptoms specific to each disease also assist in diagnosis. For instance, the presence of a fistula, more common in Crohn’s, or the existence of persistent and bloody stool, more associated with ulcerative colitis, can suggest one diagnosis over the other.
To read more, check out the original article published on?Tandem Clinical Research.