Cracking the Human Genome: Step towards unfolding the complexities of human genome sequence

What’s the buzz? Two decades after the Human Genome Project delivered the first draft?human genome sequence, scientists have published the first complete, gapless sequence of a human genome. The Telomere to Telomere (T2T) consortium led by experts from the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, the University of California, Santa Cruz, and the University of Washington, Seattle, carried out the research. The study was primarily funded by the National Human Genome Research Institute (NHGRI).

What triggered the innovation? Since its initial publication in 2000, the human reference genome has only covered the euchromatic fraction of the genome, leaving major heterochromatic regions unfinished. The full genome sequence was needed to understand the genetic contributions to various disorders, and it will be especially useful in studies aimed at establishing comprehensive views of human genomic variation, or how people's DNA varies.

What triggered the innovation? Since its initial publication in 2000, the human reference genome has only covered the euchromatic fraction of the genome, leaving major heterochromatic regions unfinished. The full genome sequence was needed to understand the genetic contributions to various disorders, and it will be especially useful in studies aimed at establishing comprehensive views of human genomic variation, or how people's DNA varies.

Innovation Benefits: This basic knowledge will help to boost the numerous continuing efforts to comprehend all the functional complexities of the human genome, which will in turn help to advance genetic studies of human disease. In the future years, sequencing a person's entire genome should become less expensive and easier. When a person's genome is sequenced in the future, scientists will be able to discover all their DNA mutations and utilise that information to better direct their treatment.