CPHMS Newsletter | September 2024
CPHMS | Centre for Predictive Human Model Systems
India's first scientific & policy think-tank dedicated to making academic and industrial research human health relevant
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Welcome back to the 12th edition of the CPHMS newsletter!
Editorial
Kasturi Mahadik, Chief Manager
The past few months have been some of the most fulfilling in my journey at our science & policy centre.
We hosted the second instalment of our Microphysiological Systems Bootcamp with C-CAMP and IISc Bangalore, which was nothing short of a triumph. It was an absolute delight to listen to the resourceful talks, engage with high-end instruments during hands-on experiments, and witness the enthusiasm of participants raising insightful questions in the realm of microfluidics, organ-chips, 3D bioprinting and organoids... Read More
Foreword
Heralding the Age of In Silico India
Nirnith Devidreddy, CEO & Founder of InSilicoMinds, AI Task Force Leader of Avicenna Alliance
As we stand on the cusp of a transformative era in the pharmaceutical landscape, it is with great enthusiasm that I contribute this foreword for the latest edition of the CPHMS Newsletter. We are witnessing the dawn of ‘In Silico India’, a movement that promises to redefine how we approach drug development, regulatory compliance, and innovation in the healthcare & life sciences sector.
India's top pharmaceutical companies, including industry leaders like Dr. Reddy's Laboratories, are at the forefront of this evolution. By focusing on In Silico and harnessing the power of computational modeling and simulation, these organizations are successfully garnering biowaivers for regulatory compliance in global markets. This shift not only streamlines the drug approval process but also enhances our capacity to deliver safe and effective medications to patients worldwide... Read More
Le Monde: Human-centric news from all over
Study Explores Potential Of 3D Printed Regenerative Breast Implants
The regenerative medicine market is poised for massive growth, driven by advancements in personalized medicine and 3D bioprinting. Cutting-edge AI innovations are accelerating organ printing, while breakthroughs like bioprinted breast implants aim to regenerate natural tissue. With the market projected to hit $49 billion by 2028, this sector is reshaping healthcare’s future.
Organ-on-Chip Standardization Roadmap
A two-year collaboration among 120 European experts and organizations has led to the establishment of the first roadmap for Organ-on-Chip (OoC) standardization. Key recommendations from this roadmap include the development of harmonized terminology, minimum reporting requirements, and comprehensive technical standards. It will be submitted to the ISO for international adoption, fostering innovation and ensuring regulatory compliance in OoC technologies.
Organ-on-chip tech could boost BioE3 goal to personalise medicine
Viraj Mehta and Manjeera Gowravaram, in an article for The Hindu, highlight the critical need to establish organ-on-chip centers in India. They discuss how this technology can advance medical research, promote personalized medicine, and support India's BioE3 goals, enhancing the nation's self-reliance in a key developmental sector.
Science Scan
Standardizing designed and emergent quantitative features in microphysiological systems
Microphysiological systems (MPS) are advanced cellular models that replicate organ functions in vitro. This article advocates for standardizing designed and emergent features in MPS to improve their physiological relevance. Establishing these standards can enhance MPS applications in drug toxicity, therapeutic discovery, and disease understanding, driving wider adoption and regulatory approval.
Modeling cancer-associated hypercoagulability using glioblastoma spheroids in microfluidic chips
Researchers at the Leiden University Medical Center have developed a 3D cancer-on-a-chip model to study excessive blood clotting in glioblastoma, a brain cancer type linked to high thromboembolism risk. By co-culturing glioblastoma spheroids with endothelial cells, the model revealed increased procoagulant activity. This innovative platform can be used to explore new anticoagulant drugs and treatments.
Development of a robotic-assisted handling and manipulation system for the high-scale bioproduction of 3D-bioprinted organ-on-a-chip devices
领英推荐
Scientists at the Technical University of Darmstadt have developed a robotic-assisted system to automate the production of 3D-bioprinted organ-on-a-chip (OoC) devices, addressing the manual labor challenges that have hindered commercial success. By integrating a 4-axis robot arm and a configurable algorithm, this innovation enables scalable, standardized bioproduction shown to achieve up to 100% success rates.
The landscape of drug sensitivity and resistance in sarcoma
Sarcomas are rare, diverse cancers with limited effective therapies. Using patient-derived tumor organoids (PDTOs), researchers tested drug resistance and sensitivity in 194 specimens from 126 patients across 24 sarcoma subtypes. Their high-throughput screening identified effective regimens for 59% of cases, offering a promising, personalized approach to improve sarcoma treatment outcomes.
Microphysiological Systems Bootcamp 2024
This August CPHMS teamed with C-CAMP and IISc Bangalore to conduct its 2nd edition of the MPS Bootcamp, aimed at advancing the use of human-relevant models among biomedical research and industries across India... Read More
Hear from the MPS Bootcamp participant
Anagha Rajesh, Chief Disruptor, BioCompute, Bengaluru
I spent the last week at the Micro-physiological Systems Bootcamp conducted by the Centre for Predictive Human Model Systems (CPHMS) in collaboration with CCAMP and the Indian Institute of Science (IISc) Bengaluru.
While the bootcamp largely focused on developing organ models for drug testing and the likes, I spent a big chunk of my time learning about the processes involved in designing and developing microfluidic channels - which is a key component in the BioCompute chip architecture that we are building... Read More
Workshop: Human Relevant Frontiers in Drug Safety and Efficacy
On July 12, 2024 CPHMS and AIC-CCMB collaborated with Central Drugs Standard Control Organization (CDSCO) and Indian Council for Medical Research (ICMR) to organize an awareness and brainstorming workshop on ‘Human Relevant Frontiers in Drug Safety and Efficacy’. This workshop aimed to stay updated on the latest developments in NAMs, focussing on complex in vitro methods and computational modeling and simulation, and to discuss strategies for advancing these areas in India, particularly involving regulators from the outset...Read More
Opportunities
Calls
Webinars
Hear from the MPS Bootcamp Speakers:
Clive's talk addresses barriers to regulatory acceptance of NAMs in chemical safety assessment. It highlights recent successes, with case studies in the cosmetics, chemical, and pharma domains, along with guidance on improving regulatory submissions.
Thierry presents NETRI, a startup pioneering high-throughput organ-on-chip technology that mimics human anatomy, enhancing drug discovery, optimizing testing, and reducing attrition rates, time to market, and costs.
Conferences
Podcasts