CPHMS Newsletter 2.0 | April 2024

Dear subscriber,

It's our birthday month, and CPHMS is turning 5! ??

Reflecting on our journey, from webinars to workshops, we've made significant strides, and there is much more ahead. To mark this milestone, we're excited to introduce the quarterly edition (2.0) of our newsletter. It's designed to offer a holistic view of all things human-centric.?

We'd love to hear your thoughts and welcome any updates or contributions to our future newsletters.

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Scientist Spotlight

Sri Harsha Paladugu is a PhD candidate at the Indian Institute of Science, Bangalore. He has developed a Multi-Organ-on-Chip (MoC) to understand breast cancer metastasis. His device paves the way for personalized cancer medicine and will potentially disrupt the drug discovery pipeline.

"At the intersection of technology and biology, engineers are the architects of transformative solutions."

This series brings you an opportunity to showcase yourself and your innovations.

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Le Monde | News from all over the world

1. How India is training next-generation human-centric scientists?
2. Human-based tech replacing animal testing in drug development. India must join in
3. Demand of Organs On Chips Market: At 28.11% CAGR, Size Worth $209.42 Million | Industry Research on Growth, Trends, Opportunity, and Analysis in 2028?
4. Tissue Engineering and Therapeutics: Takeaways from a Scientific Workshop
5. Why does India urgently need a Legal Framework for Genomics?
6. Assembloids to model sensory neurological pathways?
7. Disrupting drug discovery and testing with human Organs-on-Chips?
8. New prototype developed to generate neurovascular tissues/organoids from autologous blood can help in precision medicine

Science Scan

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Organoids and Spheroids

1. Altered neuroepithelial morphogenesis and migration defects in iPSC-derived cerebral organoids and 2D neural stem cells in familial bipolar disorder
2. High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing
3. Closing in on cancer heterogeneity with organoids

Microfluidics, Organ-on-chip and 3D Bioprinting

1. Engineering models of head and neck and oral cancers on-a-chip
2. Cancer-on-a-chip model shows that the adenomatous polyposis coli mutation impairs T cell engagement and killing of cancer spheroids
3. Modeling dry eye with an air-liquid interface in corneal epithelium-on-a-chip
4. 3D bioprinting of liver models: A systematic scoping review of methods, bioinks, and reporting quality
5. Microfluidic high-throughput 3D cell culture

Computational Biology and Imaging Techniques

1. Genome-wide repeat landscapes in cancer and cell-free DNA?
2. Atomically accurate de novo design of single-domain antibodies
3. Open-top multisample dual-view light-sheet microscope for live imaging of large multicellular systems

Changing Paradigms

1. Creating Tiny Human “Organs” to Test medicines… and More!
2. Transitioning biomedical research towards human-centric methodologies: systems-based strategies
3. Revolutionizing developmental neurotoxicity testing – a journey from animal models to advanced in vitro systems
4. The (misleading) role of animal models in drug development
5. The benefits of validation of methods for toxicity testing outweigh its costs
6. Confronting the bias towards animal experimentation (animal methods bias)

Opportunities?

Job roles:

• Postdoc Position, Institute of Neuroanatomy and Developmental Biology, Baden-Wurttemberg, Germany?
• Computational Intern - Organoid Phenotyping, Institute of Human Biology, Basel, Switzerland
• Research Assistant III – Immune Organs-on-Chip, Wyss Institute at Harvard University
• PhD scholarship programme Mosaic 2.0, Dutch Research Council (NWO)?

?Grants:?

• International 3Rs Prize

Webinars

• Reconstructed human skin models as reliable tools for topical toxicity testing (March 20, 2024)
• 3RsC Microphysiological Systems Workshop | Immune Competent & Lymph Node MPS (March 26, 2024)
• EUROoCS digital meeting | Organ-on-Chip (OoC) technology (April 23, 2024)
• Animal Welfare Information Center (AWIC) Webinar (May 8 and 9, 2024)

Join our collaborators Humane Society International India and engagement partners BIRAC and STEMPeers? on Apr 24 for an insightful discussion on standardizing OoCs and improving investments.?

Register here

Conferences / Trainings

• New Approach Methods (NAMs) Tools Training Workshop , April 24–25, 2024, Durham, North Carolina
• 3Rs-Research and Progress 4th International Conference , May 4, 2024, Hyderabad, India
• AI IN Biomedicine , May 01-03, 2024, Virtual Conference, United States?
• 1st International Conference of the Würzburg Initiative 3R (WI3R) , June 5-7, 2024, Bavaria, Germany
• LIVe2024 , June 20-21, 2024, Nice, France
• Microphysiological Systems World Summit , June 10-14, 2024, Seattle, Washington
• 5th International Conference on Stem Cell , June 27–28, 2024, Paris, France
• EUROoCS Conference 2024 , July 3-5, 2024, Milan, Italy
• EUROoCS Summerschool 2024 , September 2-6, 2024, Eberhard Karls University Tübingen, Germany
• BioMedEng24 , Queen Mary University of London, September 5-6, 2024, Mile End Road, London