C&P#130: CBD for rare conditions + cannabis for Crohn’s & Parkinson’s
Lex Pelger
'Cannabinoids & the People' newsletter on Substack + canna-edu vids on YT @cannabinoidsandthepeople + the Moby Dick pot books (graphic novels on cannabis)
[As always, for the best formatting, see the edition on Substack:
This week…
Hello everyone,
Welcome to the 130th edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science + assorted canna-news & psychedelic updates. Upgrade to a paid subscription here to support my work sharing canna-science.
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Sponsor: The Cannabis & Health Research Initiative
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Want to help expand the knowledge of medical cannabis use in the real world & get paid 100 bucks to do so?
Johns Hopkins University, with support from Realm of Caring, is spearheading the groundbreaking National Cannabis Study to evaluate the benefits, risks & overall outcomes of using cannabis for conditions like pain, insomnia, anxiety & more. If you are an adult in the U.S. considering starting cannabis for health reasons, this is your chance to help shape the future of cannabis research — and get compensated for your time. Join now to share your experience & contribute valuable data that could revolutionize healthcare for many patients nationwide. To learn more & sign up, visit:
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Or follow along on Instagram to keep on learning:
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Free resources
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For more from Lex… (my Linktree)
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A request to spread the word
This newsletter only spreads by word of mouth,
so please forward to colleagues & tell your friends & relatives.
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My work this week:
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Canna-Edu Vids for CV Sciences:
(on YT @CVSciencesInc & TT @pluscbd)
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My Vids:
(on TT @lexpelgerandhisbooks or on YouTube)
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Ways to support this work:
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Best Of Cannabinoid Science...
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An evidence map for medical cannabis covers 194 studies
Charting the therapeutic landscape: a comprehensive evidence map on medical cannabis for health outcomes
“Seventy-one distinct health outcomes were identified in the systematic reviews, with the most reported outcomes being related to various types of pain and patient safety. Other frequently studied outcomes included appetite regulation, chemotherapy-induced nausea and vomiting, and muscle spasticity. Notably, 278 out of 489 descriptions of treatment effects for these health outcomes reported either “Positive” or “Potentially Positive” effects. When considering only high-quality systematic reviews, as evaluated by the AMSTAR 2 tool, 42 out of 67 descriptions of treatment effects for up to 20 health outcomes were classified as “Positive” or “Potentially Positive.” These outcomes included pain, insomnia, seizures, anxiety, muscle spasticity, multiple sclerosis, urinary incontinence, anorexia, and patient safety.”
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A new book on the clinical cannabis science
Cannabis Science and Therapeutics: The Essential Guide for Clinicians
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Clinical
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For chronic pain & PEA, a meta-analysis including eighteen studies & ~1200 patients found that PEA reduced pain and & enhanced quality of life
Meta-Analysis of Palmitoylethanolamide in Pain Management: Addressing Literature Gaps and Enhancing Understanding
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In people getting dental implant surgery, taking 1200 milligrams of ultra-micronized PEA for a month after the surgery led to significantly reduced postoperative swelling, pain & trismus (overly tightened jaw muscles)
Efficacy of Ultra-Micronized Palmitoylethanolamide 600 MG (UM-PEA) for Sub-Lingual Use on Postoperative Course after Dental Implant Surgery: Multicentric Randomized Trial
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In Crohn's disease, a meta-analysis found cannabis users had higher remission rates & improved quality of life
Cannabis use in Crohn’s disease: a systematic review and meta-analysis of randomized controlled trials (RCTs)
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In children with drug-resistant encephalopathies (brain swelling that causes developmental & epileptic symptoms), their CBD exposure increased when taken with food
Population pharmacokinetics of cannabidiol and the impact of food and formulation on systemic exposure in children with drug-resistant developmental and epileptic encephalopathies
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From public health data, adult-use cannabis laws linked to lower levels of opioid overdose deaths of approximately 3.5 deaths per 100,000 individuals
Because I Got High? Recreational Marijuana Legalization's Impact on Opioid Overdose Deaths
And in a study of cannabis laws & opioid use, medical & adult-use laws did not change opioid outcomes for the general population but among cannabis users, medical cannabis laws were linked to decreased opioid outcomes
The relationship of medical and recreational cannabis laws with opioid misuse and opioid use disorder in the USA: Does it depend on prior history of cannabis use?
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In older adult cannabis users, there was no evidence that cannabis increased their risk of high blood pressure or hypertension
Blood pressure and hypertension in older adults with a history of regular cannabis use: findings from the Multi-Ethnic Study of Atherosclerosis
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For pharmacists, on creating personalized cannabis formulations
Optimization and Evaluation of Cannabis-Based Magistral Formulations: A Path to Personalized Therapy
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In people with cannabis use disorder, transcranial magnetic stimulation to the left dorsolateral prefrontal cortex reduced cue-induced cravings
A Secondary Analysis Suggests That Repetitive Transcranial Magnetic Stimulation Applied to the Left Dorsolateral Prefrontal Cortex Reduces Cue-Induced-Craving in Treatment Seeking Participants with Cannabis Use Disorder
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For the human emotional response to social touch, higher anandamide levels were associated with reduced preference for touch
Endocannabinoid contributions to the perception of socially relevant, affective touch in humans
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In brain scans of cannabis users, they had increased EEG signal complexity
Cortical Complexity Alterations in Methamphetamine, Cannabis, and Opioid Users: An EEG-Based Analysis
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In dogs with epilepsy, 30 days of CBD reduced inflammatory cytokines & provided benefits when combined with antiepileptic drugs
Cytotoxicity and Immunomodulatory Effects of Cannabidiol on Canine PBMCs: A Study in LPS-Stimulated and Epileptic Dogs
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In horses, there were no adverse effects from CBD or CBDA (1 mg/kg)
Chronic oral dosing of cannabidiol and cannabidiolic acid full-spectrum hemp oil extracts has no adverse effects in horses: a pharmacokinetic and safety study
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Case Reports (the good & bads)
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For Parkinson's disease, a case report on cannabis oil restoring mobility, appetite & mood
Cannabis oil in treating Parkinson’s disease: improvement of motor and non-motor symptoms: a case report
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In a person with White Sutton Syndrome (a genetic mutation of intellectual disabilities, developmental delays & epilepsy), after the failure of many conventional antiseizure medications, the off-label use of CBD caused complete remission from seizures
White Sutton Syndrome and cannabidiol: an update on a reported patient with a successful response to off-label therapy
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In a case report someone with both Lennox–Gastaut Syndrome (the severe childhood epilepsy) & Alpha-1,3-Mannosyltransferase-Congenital Disorder of Glycosylation (ALG3-CDG: a rare genetic disorder of early neurological abnormalities, abnormal facial features & eye problems), CBD & changes to diet led to seizure freedoms for over 13 months, significant improvements to EEG scans & enhanced developmental outcomes
First case report of effective and safe application of cannabidiol to treat concurrent ALG3-CDG and Lennox–Gastaut Syndrome
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Three case reports of cannabis allergies in the Mediterranean region
Cannabis sativa as a clinically relevant nsLTP allergen in the Mediterranean region: a case series exemplifying different possible routes of sensitization
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A case report of an adolescent with catatonia & their first psychosis episode after THC use
A Case of First-Episode Psychosis with Catatonic Features in an Adolescent Following THC Use
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For psychosis from delta-8 THC, a systematic review of 6 case reports involving 9 patients
Evaluating Delta-8-THC–Induced Psychosis: A Systematic Review
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In two case reports, the synthetic cannabinoid HHC-C8 caused coma, recurring seizures & pronounced sedation
Prolonged sedation and unconsciousness after intoxication with the novel semisynthetic cannabinoid hexahydrocannabioctyl (HHC-C8): Two case descriptions
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In a ketamine & cannabis user, a case report of sudden death from the bridging of a descending artery
The role of myocardial bridge of the left anterior descending artery in a sudden death of a ketamine and cannabis user. Addressing the uncertainties on the cause of death in a forensic pathologist’s casework
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In Colombia's Aburrá Valley, an analysis of 113 cases of dogs with cannabis poisoning
Marijuana Poisoning in Canines in the Aburrá Valley (Antioquia‐Colombia), 2023‐2024
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Harms
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For cannabis & the heart, a meta-analysis covering 1.9 million people found a significant association with any adverse cardiovascular event but not specifically for heart attacks or strokes
Cannabis use and atherosclerotic cardiovascular disease outcomes: A meta-analysis of multinational cohort data
And on cannabis & the heart, a systematic review of 110 cases linked to heart attacks & arteritis (inflamed arteries)
Associations Of Cannabis Use With Cardiovascular And Cerebrovascular Diseases: A Systematic Review
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For oral health, THC users had a higher level of decayed, missing & filled teeth
Frontiers | Comparative Effects of Methamphetamine, Cannabis, and Polysubstance Use on Oral Health
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On prenatal cannabis exposure, a review of later adverse neuropsychiatric outcomes
Maternal Cannabis Use During Pregnancy and Neuropsychiatric Adverse Outcomes During Childhood and Early Adult Life
“Currently available research suggests that prenatal cannabis exposure is associated with increased risks of ASD, ADHD, psychosis proneness, psychotic like experiences, internalizing problems, externalizing problems, attention problems, thought-related problems, social problems, impaired executive function, and observed aggression. There is insufficient study of prenatal cannabis exposure and offspring IQ.”
And for prenatal cannabinoid exposure in rats, as young adults they had negative effects on their cardiorespiratory regulation with gendered differences
Prenatal cannabinoid exposure affects central cardiorespiratory control in young male and female rats
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In Nigeria, a one hour session with three doctors on treating cannabis use disorder
ISSUP Nigeria Knowledge Update Series (24th Session): Cannabis Use Disorder - Changing Trends and Treatment Approaches
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For cannabis smoking & neurological abnormalities, immunity & changes to the oral microbiome, a thesis project reviewing the evidence
Cannabis use, oral dysbiosis, and neurological disorders
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For the dual vaping of cannabis & nicotine, a review of who's doing it & their higher susceptibility to respiratory & systemic symptoms
Exploring the Practice of Dual Vaping: Health Risks and Behavioral Patterns in Nicotine and Cannabis E-Cigarette Users
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A book focusing on the negatives of cannabis
The Other Side of Cannabis: Impact on Mental and Physical Health
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In human lung cells, cannabis vaping & smoking upregulated genetic transcription related to inflammation, cancer & cellular stress & downregulated transcription of pathways related to lipid synthesis & metabolism “suggesting potential impairment of lung epithelial cell repair and function”
Cannabis vaping elicits transcriptomic and metabolomic changes in inflammatory, oxidative stress and cancer pathways in human bronchial epithelial cells
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In zebrafish embryos, a brief THC exposure not only shortened length & altered hatching, response times & survival but some of these effects lasted into the next generation
Brief exposure to (-) THC affects zebrafish embryonic locomotion with effects that persist into the next generation
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In a roundworm model of pesticide exposure, 55 pesticides were tested against 95 genes & showed the greatest effect on lowered dopamine synthesis
Regulatory Trends of Organophosphate and Pyrethroid Pesticides in Cannabis and Applications of the Comparative Toxicogenomics Database and Caenorhabditis elegans
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Reviews
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For neuropsychiatric disorders, a review of how CBD's ability to bind to many receptors powers its efficacy (great chart!)
Therapeutic potential of cannabidiol polypharmacology in neuropsychiatric disorders
And for neurological disorders, a review of 47 clinical trials found the most evidence for multiple sclerosis, fibromyalgia & Parkinson's disease
Therapeutic Potential of Cannabinoids in Neurological Conditions: A systematic Review of Clinical Trials
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For autism, a review of CBD-rich extracts covering 350+ people noted improvements “in behavioral symptoms, social responsiveness, and communication, but cognitive benefits were less consistent”
The Evolving Role of Cannabidiol-Rich Cannabis in People with Autism Spectrum Disorder: A Systematic Review
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For CBD's antidepressant effects, this review implicates the possible involvement of the 5-HT1A (serotonin), CB1, GPR55 & PPARγ (nuclear) receptors
novel insight into the antidepressant effect of cannabidiol: possible involvement of the 5-HT1A, CB1, GPR55, and PPARγ receptors
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For pediatric health conditions, a review of 10 studies of cannabis products for autism, cancer, treatment-resistant epilepsy & Sturge-Weber syndrome
Use of Cannabis-Based Medical Products for Pediatric Health Conditions: A Systematic Review of the Recent Literature
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For migraines, a review of the efficacy & mechanisms of cannabinoids
Endocannabinoids, Phytocannabinoids, and Migraine
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In epilepsy, a review on the neuroprotective effects of CBD & THC
Assessing the neuroprotective benefits of Cannabis sativa in epilepsy management
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For post-organ transplant care, a review of using CBD for its anti-inflammatory effects
Utilization of Cannabidiol in Post-Organ-Transplant Care
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For energy balance & obesity, a review of the intersection between endocannabinoids, exercise & leptin (a hormone of appetite suppression)
The interplay of leptin and the peripheral endocannabinoid system in energy homeostasis and obesity; modulation by linoleic acid and exercise
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For ophthalmology, a review of targeting the endocannabinoid system & a description of its involvement in the eyes
The Endocannabinoid System and Ophthalmic Pathologies: A Review of Molecular Mechanisms and Its Implications for Clinical Practice
And on the CB1 receptor in the retina, a thesis project on their widespread distribution across retinal cell types, their varied effects & their gendered response to stress
Roles of the CB1 receptor and the endocannabinoid system in the retina
And in the eye of a cow, the neuroprotective actions of 2-AG & methanandamide (a stable cousin of anandamide) involved hydrogen sulfide
Neuroprotective Actions of Cannabinoids in the Bovine Isolated Retina: Role of Hydrogen Sulfide
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For chronic pain, a review on using the cannabinoids
Cannabis for Chronic Pain: Mechanistic Insights and Therapeutic Challenges
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For CBG, a review of its molecular actions & therapeutic effects (great charts!)
Cannabigerol (CBG): A Comprehensive Review of Its Molecular Mechanisms and Therapeutic Potential
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For beta-caryophyllene (one of the most common terpenes in cannabis), a review of its wide-ranging effects & its ability to activate the CB2 receptor
A Systemic Review of Beta-Caryophyllene
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Preclinical
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In a rat model of working memory, THC enhanced memory in aged rats while having no effect in young adults
Cannabis smoke and oral Δ9THC enhance working memory in aged but not young adult subjects
As an aged rat myself, I find this research hopeful.
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In a mouse model of Alzheimer's disease, CBD boosted acetylcholine signaling, improved cognitive function & reduced senile plaques
Boosting Acetylcholine Signaling by Cannabidiol in a Murine Model of Alzheimer's Disease
And in a computer & mouse model of Alzheimer’s disease, CBDA & CBGA improved cognitive deficits via AChE/BuChE, BACE-1 & TRPM7s
Identification of Cannabidiolic and Cannabigerolic Acids as MTDL AChE, BuChE, and BACE-1 Inhibitors Against Alzheimer's Disease by In Silico, In Vitro, and In Vivo Studies
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In a mouse model of pain from colitis, CBD, CBG, CBC & CBDV reduced visceral hypersensitive pain
Entourage effects of non-psychotropic cannabinoids (npCBs) on visceral sensitivity in experimental colitis
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In a mouse model of kidney damage from chemotherapy treatment, cannabis extract improved urinary parameters, restored migratory capacity & prevented apoptosis (programmed cellular suicide)
Lebanese Cannabis sativa L. extract protects from cisplatin-induced nephrotoxicity in mice by inhibiting podocytes apoptosis
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In a mouse model of muscular dystrophy, full-spectrum CBD oil decreased inflammation, reduced scarring & improved muscle parameters
Treatment With Full‐Spectrum Cannabidiol Oil Improved the Pathological Findings of Dystrophic Mutant Mice
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In an elderly rat model of intestinal ischemia (loss of blood flow), CBD significantly reduced intestinal injury & increased absorptive function
Cannabidiol as prophylactic treatment for intestinal ischaemia reperfusion injury in elderly rats
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In a mouse & tissue model of atopic dermatitis (eczema, dry itchy inflamed skin), CBG downregulated inflammatory markers via the JAK/STAT/NFκB pathway
Anti-Inflammatory Effects of Cannabigerol In Vitro and In Vivo Are Mediated Through the JAK/STAT/NFκB Signaling Pathway
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In a mouse model of toxicity from cadmium, CBD reversed oxidative stress markers, reduced proinflammatory cytokines & protected the liver & kidney from damage
Investigation of Cannabidiol's Protective Effects on Cadmium‐Induced Toxicity in Mice
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In a rat model of anxiety, CBD reduced avoidance behavior via changes to the lipid network in the nucleus accumbens shell (a region of neural interface between motivation & action)
Cannabidiol abrogates cue-induced anxiety associated with normalization of mitochondria-specific transcripts and linoleic acid in the nucleus accumbens shell
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In a rat model of morphine use disorder, treatment with CBD only lessened withdrawal behavior in male rats
Morphine-induced side effects can be differentially modulated by ...
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In a mouse model of vaporized cannabis, the highest doses caused painkilling, locomotor suppression, & hypothermic effects with gendered differences in plasma THC levels
Influence of solvent, sex, and age on pharmacokinetic and acute behavioral effects of vaporized cannabis extract in mice
And for cannabis ethanol extracts, an analysis of their cytotoxic, anti-inflammatory & anticancer potential
EXTRACTION, GC-MS ANALYSIS, CYTOTOXIC, ANTI-INFLAMMATORY AND ANTICANCER POTENTIAL OF CANNABIS SATIVA FEMALE FLOWER; IN VITRO, IN VIVO AND IN SILICO
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In lung cells exposed to radiation (similar to a cancer treatment), CBD reduced oxidative stress, proinflammatory cytokines & apoptosis (program cellular suicide)
Cannabidiol (CBD) Protects Lung Endothelial Cells from Irradiation-Induced Oxidative Stress and Inflammation In Vitro and In Vivo
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In human intestinal cells, CBD reduced oxidation, upregulated signaling of the mitochondria (powerhouse of the cell) & supported the intestinal barrier
Cannabidiol Enhances Mitochondrial Metabolism and Antioxidant Defenses in Human Intestinal Epithelial Caco-2 Cells
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In a neuronal model of pain, CBD, CBG & CBN inhibited the voltage-gated sodium channels for less excitability of pain signals, with CBG being the strongest
Nav1.8, an analgesic target for nonpsychotomimetic phytocannabinoids
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In fat stem cells, THC decreased their proliferation but increased their metabolic activity & differentiation
?9-Tetrahydrocannabinol Increases Growth Factor Release by Cultured Adipose Stem Cells and Adipose Tissue in vivo
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Against human pathogenic bacteria, cannabis ethanol extracts (from a Thai cultivar) had antibacterial properties
Evaluation of the Antibacterial Potential of Ethanolic Cannabis sativa L. (Hang Kra Rog Phu Phan ST1) Extracts Against Human Pathogenic Bacteria
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Novel Studies
(my new grab bag section for stuff I haven’t quite seen before)
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In a cannabis consumption lounge, an analysis of the fine & ultrafine particle concentrations
Fine and Ultrafine Particle Concentrations in a Cannabis Consumption Lounge
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For cannabis leaves as leftover biomass, an analysis of their anti-inflammatory effects
Enhancing Industrial Hemp (Cannabis sativa) Leaf By-Products: Bioactive Compounds, Anti-Inflammatory Properties, and Potential Health Applications
There's a long human history with hemp leaves as a medicine that has fallen off in the last century or two.
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The minor cannabinoid CBL increases activity at the serotonin 5-HT1A receptor (positive allosteric modulation)
An Unexpected Activity of a Minor Cannabinoid: Cannabicyclol (CBL) Is a Potent Positive Allosteric Modulator of Serotonin 5-HT1A Receptor
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On inhibiting a viral enzyme complex from the COVID virus using the cannabinoid-inspired inhibitor chromenephenylmethanone-1 (CPM-1)
Cannabinoid-Inspired Inhibitors of the SARS-CoV-2 Coronavirus 2'- O-Methyltransferase (2'- O-MTase) Non-Structural Protein (Nsp10-16)
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The essential oils from lavender & hops inhibited the MAGL enzyme (which synthesizes 2-AG)
Lavender and hops essential oils inhibit monoacylglycerol lipase through an uncompetitive kinetic mechanism
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In the roots of Achillea millefolium L. (yarrow), endocannabinoid components were found that inhibited the FAAH & MAGL enzymes
Bioassay-Guided Isolation and Analysis of Phytochemicals with Endocannabinoid Activity in Achillea millefolium L.
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For navelina oranges (Citrus sinensis), their anti-inflammatory & anti-fibrotic (scarring) effects seemed to be mediated by the CB2 receptor
Anti-Inflammatory and Anti-Fibrotic Effects of a Mixture of Polyphenols Extracted from “Navelina” Orange in Human Hepa-RG and LX-2 Cells Mediated by Cannabinoid Receptor 2
And in the traditional Chinese medicine Schisandra chinensis used for treating stress, it caused an antidepressant effect & improved the disrupted levels of endocannabinoids via the CB2 receptors of the microglia (guardian immune cells of the brain) & the PERK-eIF2α pathway
Schisandra chinensis lignans exerts endocannabinoids-like antidepressive effect: The phagocytotic relationship of activated CB2R-mediated M2 microglia and “stressed-but-viable” neuron
Two more for our long list of plants/old medicines whose benefits work via the ECS.
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the Headlines & Fav Articles
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A new memo grants immigration enforcement powers to the DEA
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Acting DEA head Derek Maltz claimed that cannabis is a "gateway drug" that's "actually causing psychosis, schizophrenia, depression [and] anxiety,"
Many in the canna-mediasphere are up in arms about this, but I’d say it’s all moderately true.
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On Bluesky, two lists of cannabis policy starter packs
I’m there, but not posting much yet because…
a. They have a 1-minute limit on video
b. I’m not sure if I have another social media platform in me
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In Mexico, public health data showed that higher levels of municipal education were linked to a higher prevalence of recreational cannabis use
Municipal socioeconomic environment and recreational cannabis use in Mexico: Analysis of two nationally representative surveys
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A feminist Chicanx history of cannabis history & resistance
Chicanx Cannabis Relationships: Cultural and Political Histories of Cannabis Resistance
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In the NHL, booze is out & weed gummies are in
And Champ Bailey of the NFL Hall of Fame on how cannabis helped him during his football career
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Paul Rubens (Pee-wee Herman) "spent my entire adult life hiding I was a huge weed head" (from his final interview)
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History Corner: In a 2nd century BCE Egyptian vase, traces of Syrian rue & Egyptian lotus (both of which get you high)
Multianalytical investigation reveals psychotropic substances in a ptolemaic Egyptian vase
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International
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Prohibition Partners released their Global Cannabis Report
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Spain reportedly on the brink of legalizing medical cannabis (though it took forever & critics say it's far too limited)
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In Germany, of the 444 cannabis club applications, only 83 have been approved so far
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In Poland, medical cannabis prescriptions are way down after telemedicine restrictions put into place + a crackdown on vaped or smokeable CBD moves forward
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Uruguay's legal cannabis market continues to grow
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Saint Lucia releases draft law to map the way for hemp & cannabis legalization this year
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In Australia, the Legal Cannabis Party calls out Meta’s hypocrisy on free speech & cannabis content suppression
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Malaysia opens Hemp Science Center
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In China, a thesis project comparing the legal policies & personal experiences of Chinese university students abroad versus in China
Chinese university students attitudes towards cannabis and related policies : a comparison of studying abroad and in China
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In Thailand, the evolving mythology of cannabis using Barthes’ theory of myth & cultural institutions based on 24 interviews
Cannabis mythology: the process of shaping from experience in Nakhon Si Thammarat, Thailand
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The Laws, The War on Drugs & Driving
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A report on the effects of rescheduling cannabis from the National Academies of Sciences, Engineering, and Medicine
Cannabis Use, Public Health, and Traffic Safety: Outcomes from the Scientific Literature and Expert Opinion on the Potential Impacts of Rescheduling
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For legalization, a call to jointly assess both health & crime-related indicators
Cannabis legalization: a call for the integration of main health and crime indicator domains towards comprehensive policy impact assessments
“While many key health-related indicators show increases in adverse outcomes, improvements are shown for main crime-related outcomes associated with legalization.”
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In this natural experiment, the opening of retail cannabis stores was not linked to increased ED visits for cannabis, alcohol or opioids
The impact of recreational cannabis retailer allocation on emergency department visits: A natural experiment utilizing lottery design
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In the marketing of cannabis edibles, on how trademark parody can lead to children accidentally ingesting cannabis products
Joke or counterfeit? Balancing trademark parody and consumer safety in the edibles market
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An essay reviewing a book focused on the international drug control system & the 1961 Single Convention on Narcotic Drugs: ‘Legalising the Drug Wars’ by John Collins
Review Essay: The flexible or inflexible nature of the international drug control system: drug prohibition regime or drug regulatory regime? A review of John Collins Legalising the Drug Wars: A Regulatory History of UN Drug Control (CUP, 2022)
If anyone was looking to get me a late Christmas present, here it is.
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In Argentina, an analysis of the raids on growers & producers of cannabis derivatives
Procedimientos policiales a personas que cultivan y producen derivados de cannabis en Argentina (2010-2020)
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For driving, an analysis of the per se limits of blood levels (such as (1, 2 & 5 ng/mL) & why there is not good data to back up their efficacy
Evaluation of Cannabis Per Se Laws: A Semi-Mechanistic Pharmacometrics Model for Quantitative Characterization of THC and Metabolites in Oral Users
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In Australia, the level of THC detected in injured drivers rose since 2010 & along with meth, was the most common drug in fatal crashes
Trends in alcohol, MDMA, methylamphetamine and THC in injured and deceased motor vehicle drivers and motorcyclists over a decade (2010–2019) in Victoria, Australia
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Business, Economics & Education
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European cannabis seeds quietly took over the US market
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In Australia, analyzing the advertising and breaches and promoting medical cannabis such as listing health conditions
Research Letter: Unveiling the boundaries: Analysing advertising breaches in the promotion of medicinal cannabis in Australia
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A proposed framework for ensuring honest cannabis laboratories called “the Peer-review Blinded Assay Test”
Peer-review Blinded Assay Test (P-BAT): a framework for trustless laboratory quality assurance for state-regulated cannabis markets
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Psychedelics, Plant Medicines & Other Psychoactives
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The FDA approved a ketamine nasal spray for treatment-resistant depression
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The Psychoactive Research
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People with an emergency department visit involving hallucinogens had a higher risk of developing a schizophrenia spectrum disorder
Emergency Department Visits Involving Hallucinogen Use and Risk of Schizophrenia Spectrum Disorder
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In people with bipolar disorder, psychedelics reduced depressive symptoms & increased the number of days without mental health symptoms
Psychedelic use and bipolar disorder – An investigation of recreational use and its impact on mental health
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For people with a terminal illness, a meta-analysis of 9 studies including 606 participants found psychedelics to have promising effects on depression & anxiety
Psychedelics as an intervention for psychological, existential distress in terminally ill patients: A systematic review and network meta-analysis
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For psilocybin & depression, a meta-analysis of six trials found positive results that were superior to the typical interventions
Randomized Controlled Trials of Psilocybin‐Assisted Therapy in the Treatment of Major Depressive Disorder: Systematic Review and Meta‐Analysis
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In the antidepressant use of psilocybin, there appeared to also be benefits for sleep disturbances
Preliminary Evidence of Sleep Improvements Following Psilocybin Administration, and their Involvement in Antidepressant Therapeutic Action
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For alcohol use disorder, a review of using psychedelics
Psychedelic Research for Alcohol Use Disorder with Comorbid Major Depressive Disorder: An Unmet Need
And for tobacco use disorder, a systematic review of using psychedelics
Psychedelics as a potential treatment for tobacco use disorder: a systematic review
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For adolescent depression & trauma, a review on the potential of MDMA & psychedelics
Therapeutic Potential of MDMA- and Psychedelic-Assisted Psychotherapy for Adolescent Depression and Trauma
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For psychedelics, introducing a condensed version of the Awe Experience Scale
Developing a short form of the Awe Experience Scale (AWE-SF) in psychedelic samples
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The Plant & the History
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On Ukrainian hemp growing terms
HEMP GROWING VOCABULARY AS A COMPONENT OF THE DICTIONARY OF THE MIDDLE BUG AREA DIALECTS
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Growing & Processing
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On the effects of air temperature & light cycles on yield
High air temperature reduces plant specialized metabolite yield in medical cannabis, and has genotype-specific effects on inflorescence dry matter production
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The bacterium Bacillus velezensis S141 increased plant growth
Mechanisms of Cannabis Growth Promotion by Bacillus velezensis S141
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Root-zone phosphorus did not improve yield
Elevated root-zone P and nutrient concentration do not increase yield or cannabinoids in medical cannabis
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On the pathogen Fusarium oxysporum & how it spreads
Virulence and dissemination enhancement of a mycoherbicide
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On the biology of the different aphids that feed on industrial hemp
Life table analyses and feeding behaviors of cannabis aphid, cotton aphid, and green peach aphid (Hemiptera: Aphididae) on industrial hemp
领英推荐
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For an industrial hemp harvester & dryer, analysis of the optimal operational parameters
Research on the Operational Parameters and Performance of Key Components of an Industrial Hemp Harvester and Drier
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On the robotic manipulation of hemp plants & a new visual feedback system
Visual Feedback System Supporting Robotic Manipulation of Hemp Plants
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On hemp seed germination & maturation rates
Determination of Germination and Emergence Performance of Hemp (Cannabis sativa L.) Seeds at Different Maturity Stages
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For cannabis seeds, how different durations of hot water exposure altered germination
EFFECT OF EXPOSURE TIME IN HOT WATER ON GERMINATION OF CANNABIS SEED
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For cannabis trichomes, an analysis of their epigenome
Characterization of the Cannabis sativa glandular trichome epigenome
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On the trichomes & the molecular machinery underpinning their production of cannabinoids & terpenes
Characterisation of Cannabis glandular trichome development reveals distinct features of cannabinoid biosynthesis
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A thesis project on how the cultivation & extraction conditions of cannabis altered the yield & bioactivity
THE EFFECTS OF CULTIVATION AND EXTRACTION CONDITIONS ON THE PHYTOCHEMISTRY AND BIOACTIVITY OF CANNABIS SATIVA L.
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In Iranian cannabis, a genetic study of the single nucleotide polymorphisms associated with their sex, yield & traits
Population genomics of a natural Cannabis sativa L. collection from Iran identifies novel genetic loci for flowering time, morphology, sex and chemotyping
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For new US farmers, surveys on their motivations to grow hemp
First-year hemp farmers’ motives and resources to cultivate hemp
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In Turkey, a survey of farmers on their motivations & experiences around hemp cultivation
ANALYSIS OF FARMERS' HEMP GROWING TENDENCIES AND EXPECTATIONS: THE CASE OF TüRK?YE
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On growing hemp in Serbia
Agroecological conditions for optimal cultivation of industrial hemp (Cannabis sativa L.) in the territory of the Republic of Serbia
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On optimizing extraction processes for CBD from hemp & an analysis of its biological activity
Optimization of Extraction and Enrichment Process of Cannabidiol from Industrial Hemp and Evaluation of Its Bioactivity
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On extracting using a green & selective supercritical fluid method
Green and selective supercritical fluid extraction of essential oil and cannabidiol from Cannabis sativa L.
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Formulating & Analyzing
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On creating an inhalable CBD powder
Cannabidiol and Hydroxypropyl-β-Cyclodextrin for the Development of Deflated Spherical-Shaped Inhalable Powder
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A review on quantifying cannabinoids with chromatographic & spectroscopic analyses
Chromatographic and Spectroscopic Analyses of Cannabinoids: A Narrative Review Focused on Cannabis Herbs and Oily Products
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Analyzing cannabinoid levels with AI & Raman microscopy
Analysis of Major Cannabinoids using Raman Microscopy, Chemometrics, and a Novel Artificial Intelligence Approach
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On measuring CBD levels in a nanoemulsion of hemp oil with a HPLC-DAD
Novel Intravenous Nanoemulsions Based on Cannabidiol-Enriched Hemp Oil—Development and Validation of an HPLC-DAD Method for Cannabidiol Determination
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For cannabis leaves from Himachal Pradesh, forensically characterizing them using a GC-MS
A review on quantifying cannabinoids with chromatographic & spectroscopic analyses Chromatographic and Spectroscopic Analyses of Cannabinoids: A Narrative Review Focused on Cannabis Herbs and Oily Products
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Food & Nutrition
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In beer production, incorporating hemp to improve drinkability & increase bitterness
Addition of Industrial Hemp (Cannabis sativa L.) Dry Inflorescence in Beer Production
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In hemp milk, an analysis of cannabinoid levels before & after fermentation
Exploring the Presence of Cannabinoids in Hemp-Infused Fermented Milk Drinks: An Analysis of Pre- and Post-Fermentation Levels
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For hemp seed oil, a review of nutritional value & industrial applications
Nutritional and Industrial Insights into Hemp Seed Oil: A Value-Added Product of Cannabis sativa L.
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For hemp seed oil, an analysis of extraction methods & temperature influence
Influence of extraction methods and temperature on hemp seed oil stability: A comprehensive quality assessment
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For hemp seed oil, the effects of different cooking temperatures & times
Effect of cooking temperature and time on the quality and safety of hemp seed oil
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A review of the nutritional & elemental attributes of the cannabis plant & seeds
An overview of physicochemical, nutritional and elemental attributes of Cannabis (Cannabaceae)
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In laying hens, adding hemp to their diet increased egg mass, reduced saturated fatty acid content, improved fatty acid ratio, lowered cholesterol levels & increased antioxidant activity
Effects of dietary hemp co-product inclusion on laying hens performances and on egg nutritional and
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In dairy cows, a large analysis of their endocannabinoid system & how supplementing their endocannabinoid system may be modulated by their reproductive stage
International Symposium on Ruminant Physiology: The involvement of the endocannabinoid system in metabolic and inflammatory responses in dairy cows during negative energy balance
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For hemp seed protein complexes with gallic acids, their antioxidant properties
Characterization of physical, structural and antioxidant properties of hemp seed and seed meal protein-gallic acid conjugates
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The effects of fermentation times on hemp seed protein gels
Impact of Probiotic Fermentation on the Physicochemical Properties of Hemp Seed Protein Gels
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Analyzing the best methods for preparing hemp protein isolates
Investigating the preparation of hemp-protein isolate (HPI)
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On the polysaccharides from hemp kernels
Characteristics of Polysaccharides from Industrial Hemp (Cannabis sativa L.) Kernels
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Industrial Uses & Fiber
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On the interest of young people on wearing hemp-based clothing
An Investigation of Young Consumers’ Acceptance of Hemp Fashion Products Using Partial Least Squares Structural Equation Modeling Analysis
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On making biodegradable leather from hemp fiber with natural rubber
Hemp fibre reinforced natural rubber bio-macromolecule based biodegradable engineered leather
For all the BDSM vegans in the back…
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For antimicrobial food packaging, a review of using the cannabinoids
Mechanisms and strategic prospects of cannabinoids use: Potential applications in antimicrobial food packaging—A review
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On the separation of hemp fast fibers, a thesis on a chemical treatment
Chemical treatment for the separation of hemp bast fibers
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On the energy consumption of creating biocomposites with hemp shives
Evaluation of Mechanical Energy Consumption in WPC Production from Pine (Pinus sylvestris) and Hemp (Cannabis sativa L.) with ABS Thermoplastic Additions
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CANNABINOID SCIENCE
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A review on the gaps in cannabis research
Where are you heading to, Cannabis research?
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A review on using machine learning for cannabis research
Applications of Machine Learning in Cannabis Research: A Scoping Review
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Public Health
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On CBD usage in the US, over 10% reported using CBD in the last 30 days & this number was significantly higher among cannabis users
Patterns of cannabidiol use among marijuana users in the United States
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From the Leafwell patient database, a descriptive analysis of their usage
Towards a comprehensive understanding of medical conditions among medical cannabis patients in a large database: A descriptive analysis
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A proposal to standardize the cannabis dose-response with the Index of Cannabis Equivalence (ICE)
The Index of Cannabis Equivalence (ICE): A User-Centered Approach to Standardization of Cannabis Dose–Response
“The Index of Cannabis Equivalence (ICE) identified the following low-dose cannabis equivalencies: two puffs on a joint, pipe, herbal or concentrate vaporizer is equivalent to one hit on a bong, a 5?mg/THC edible, and ? dab of a concentrate.”
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Cannabinoids may bioaccumulate more than currently suspected
Is the potential for bioaccumulation of cannabinoids underestimated? Insights from biomimetic chromatography in cannabinoid exposure evaluation
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In British Columbia, a sociological analysis of how low-threshold medical cannabis access points influenced individual’s use
“Becoming a Medical Cannabis User” Revisited: Understanding the Role of Low-Threshold Access Points in British Columbia, Canada
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In cannabis use patterns of US adults, a comparison of medically recommended versus non-medical cannabis use patterns
Medically Recommended vs Nonmedical Cannabis Use Among US Adults
And a study of the prevalence of usage between those two different populations
Prevalence of cannabis consumption methods among people with medically recommended and nonmedical cannabis use in the United States
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In Queer & straight adults, positive affect was associated with subsequent cannabis use & negative affect was negatively related to cannabis use
Positive and negative affect differentially relate to alcohol and cannabis use in LGBTQ+ and cisgender–straight heavy-drinking adults: Results of an ambulatory assessment study
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On reducing medical cannabis use by veterans (though I think we should be working to increase it)
Reducing medical cannabis use risk among Veterans: A descriptive study
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How you describe the simultaneous use of cannabis & alcohol is associated with how much you use them
Descriptive norms for simultaneous cannabis and alcohol use predict simultaneous use patterns assessed via daily surveys.
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A review of self-medicating with cannabis
"Self-Medication with Cannabis"
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Adolescents & Young Adults
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For young people, a systematic review on how their earlier age of cannabis use onset is associated with later cannabis use disorder
Age of onset of cannabis use and substance use problems: A systematic review of prospective studies
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In young adults, those with cannabis use disorder also had higher levels of synthetic cannabinoid polysubstance use
The Association Between Past 12-Month Synthetic Cannabinoid Polysubstance Use and Cannabis Use Disorder in a Nationally Representative US Sample
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Among adolescents, cannabis dependency was linked to higher school absenteeism rates & worse performance on executive function tasks
The Impact of Cannabis Dependency on Executive Functions and Their Link to School Dropout Among Adolescents
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In young gender diverse adolescents, they were more likely to experiment with cannabis, nicotine & alcohol
Association between gender diversity and substance use experimentation in early adolescents
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In college students, adverse childhood experiences predicted more cannabis use
Do Adverse Childhood Experiences and Depressive Symptoms Predict Cannabis Use among College Students of Color
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In college men who experienced cyber dating abuse, they were more likely to use cannabis the next day
Does cyber dating abuse victimization predict next-day alcohol and cannabis use among college students?
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In adolescents with a genetic risk for adult cannabis use disorder, they tended to use more substances, have higher levels of impulsivity, risk-taking, sensation seeking & novelty seeking as well as alterations to their white matter structure
Impulsivity behaviors and white matter mediate the relationship between genetic risk for cannabis use disorder and early cannabis use in adolescents
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In college students, impulsivity & delay discounting showed a moderate correlation to alcohol use & lifetime cannabis use
Associations Between Personality and Neurocognitive Risk Factors for Substance Misuse with Alcohol and Cannabis Use in College Students
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In young adults, an analysis of their cannabis use, associated problematic outcomes & factors around quitting
Cannabis use characteristics and associations with problematic use outcomes, quitting-related factors, and mental health among US young adults
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In young adults, on a type of survey for estimating their total quantities of THC & CBD ingested
Using ecological momentary assessment to quantify Δ-9-tetrahydrocannabinol and cannabidiol use across different forms of cannabis: Feasibility in a sample of Canadian young adults reporting frequent cannabis use
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In schools near Fort Worth, Texas, the retail availability of delta-8 THC in 2021
Retail Availability of Delta-8 THC Near Schools, Fort Worth, Texas, 2021
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For young adult cannabis use, a model of how social dynamics alter their usage
Model Building with Youth: Applying a System Science Approach to Examine the Dynamic Social Context of Adolescent and Young Adult Marijuana Use
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For youth, a model for predicting the risk of developing alcohol use disorder & cannabis use disorder
A Bayesian Learning Model for Joint Risk Prediction of Alcohol and Cannabis Use Disorders
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For cannabis use disorder in young people, AI to predict their susceptibility
Absolute Risk Prediction for Cannabis Use Disorder Using Bayesian Machine Learning
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Validation of the Serbian questionnaire on cannabis effects for adolescents
Validation and adaptation of the Serbian adaptation of the Marijuana Effect Expectancies Questionnaire among adolescents
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The Brain & Neurological Disorders
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In brain scans of people with cannabis use disorder, their brain volume scores were within normal ranges for both sexes while females had greater cortical thickness than males in 14 different regions
Sex differences in normative modeling of cortical thickness in cannabis use disorder
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In older adults, on the relationship of their circulating endocannabinoid & fatty acid levels to cognitive performance
Circulating Endocannabinoids and Cognitive Function in Older Adults
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For Hermansky–Pudlak syndrome (a rare genetic disorder of albinism & bleeding problems), anandamide could serve as a blood biomarker for pulmonary fibrosis (lung scarring)
Anandamide Is a Potential Blood Biomarker of Hermansky-Pudlak Syndrome Pulmonary Fibrosis
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In a mouse model of Alzheimer's disease, inhibiting the FAAH enzyme (which degrades anandamide) “fully reverted neurocognitive decline”, lessened neuroinflammation & promoted neuroprotection
Fatty‐acid amide hydrolase inhibition mitigates Alzheimer's disease progression in mouse models of amyloidosis
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In a mouse model of Parkinson's disease, activation of the CB2 receptor not only decreased inflammation but also formed receptor heteromers (joined receptor units) with NMDA glutamate receptors to lessen their detrimental increased signaling
The interplay between CB2 and NMDA receptors in Parkinson’s disease
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In female rats, inhibiting the diacylglycerol lipase α enzyme (DAGLα – which synthesizes 2-AG) reduced the integrity of the blood-brain barrier & increased vascular reactivity
Inhibition of diacylglycerol lipase α induced blood–brain barrier breach in female Sprague–Dawley rats
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In neuronal cells, various types of lysophosphatidylinositol (an endocannabinoid that activates the GPR55 receptor) caused different changes to neuroinflammation
Effect of Fatty Acyl Composition for Lysophosphatidylinositol on Neuroinflammatory Responses in Primary Neuronal Cultures
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In brain cells, the interactions of the cannabinoid & muscarinic acetylcholine receptors for synaptic plasticity In the hippocampus (memory center of the brain)
Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection
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Mental Health, Addiction & Cannabis Use Disorder
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On how cannabis can induce depersonalization & derealization
Depersonalisation and Weed
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In cannabis users seeking treatment for opioid use disorder, buprenorphine was associated with reduced cannabis use while extended-release naltrexone wasn't
Effects of randomization to buprenorphine or naltrexone for OUD on cannabis use outcomes: A secondary analysis of the X:BOT trial
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In people with trauma history, a survey found that cannabis potency was significantly correlated with cannabis dependence & anxiety levels, but only when assessed via THC proportion and not THC:CBD ratio
The roles of cannabis potency and gender in cannabis dependence and anxiety in recent cannabis users with trauma exposure histories
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In humans with PTSD, the gendered differences in their endocannabinoid & inflammatory markers
Sex Differences in Endocannabinoid and Inflammatory Markers Associated with Posttraumatic Stress Disorder
“Male PTSD patients showed a significant decrease in AEA, AA [arachidonic acid] and OEA [oleoylethanolamide] levels compared to male controls … and to female subgroups.”
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In people with schizophrenia spectrum disorders & cannabis use disorder, treatment with partial dopamine agonists (aripiprazole or brexpiprazole) improved negative symptoms, craving & general psychopathology
Partial Dopamine D2/3 Agonists and Dual Disorders: A Retrospective-Cohort Study in a Real-World Clinical Setting on Patients with Schizophrenia Spectrum Disorders and Cannabis Use Disorder
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For the dual use of cannabis smoking & vaping, people were more likely to experience severe externalizing symptoms
Examining the Relationship of Cannabis use Patterns, Mental Health, and Sociodemographic Factors: A Focus on Cannabis Vaping, Smoking and Dual-Use
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For substance use disorders, a review of using cannabinoids
Cannabinoid-based Pharmacology for the Management of Substance Use Disorders
And for alcohol use disorder, a review of using cannabinoids
Cannabinoid for alcohol use disorder
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For sleep, a review on a bidirectional model of medicating with cannabis leading to worse sleep problems
Sleep Health, Self-Medication, and Cannabis Risk: A Bidirectional Model and Research Agenda
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For anxiety, a thesis project reviewing the evidence for the involvement of anandamide
Anandamide and anxiety
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In a rat model of cannabis withdrawal, they had reduced brain activity in their rostromedial tegmental nucleus (a center of averse stimuli & behavioral inhibition) & lateral habenula (a center of learning, motivation & addiction)
Functional Adaptation in the Brain Habenulo-Mesencephalic Pathway During Cannabinoid Withdrawal
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In a rat model of anxiety, blocking the CB1 receptor reduced their social deficits from empathic pain in witnessing the pain of other rats
The Modulatory Effects of CB1 Receptors on Social Behavior and Anxiety in Rats: Insights from an Empathic Pain Paradigm
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In a mouse model of threat reactivity, cannabinoids increased activity in the amygdala & altered the dynamics of the somatostatin neurons
Cannabinoid Modulation of Central Amygdala Population Dynamics During Threat Investigation
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Pain, Musculoskeletal & Surgeries
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In people who had spinal fusion surgery, those with a history of cannabis use were less likely to be using opioids postoperatively & had lower rates of high-dose opioid utilization
Effect of cannabis use history on postoperative opioid utilization in lumbar fusion patients: an American retrospective study
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For musculoskeletal pain, a survey found that orthopedic patients are highly interested in cannabis-based products
Orthopedic Patients Are Highly Amenable to Cannabis-Based Products for the Treatment of Musculoskeletal Pain
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For chronic pain, a review of 22 trials on using the cannabinoids
Exploring Natural Analgesics for Chronic Pain Management: Cannabinoids and Other Phytoconstituents
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In a mouse model of arthritis, activating the CB2 receptor reduced paw swelling, lowered spleen index, reduced inflammatory cell migration & bone erosion & preserved joint integrity via the Th17/Treg balance
Cannabinoid receptor 2 selective agonist ameliorates adjuvant-induced arthritis by modulating the balance between Treg and Th17 cells
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In a mouse model of spinal cord injury, dysfunctions in anandamide & the CB1 & TRPV1 vanilloid receptors led to a maladaptive hyperactive pain state
Maladaptive changes in the homeostasis of AEA-TRPV1/CB1R induces pain-related hyperactivity of nociceptors after spinal cord injury
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In a mouse model of pain, a thesis project on how activating the CB2 receptor alleviated pain without producing tolerance & also prevented the development of tolerance to morphine
Examination of CB2 Cannabinoid Receptor Agonist LY2828360 in Reducing Mechanistically Distinct Forms of Pain in Rodents
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For neuropathic pain, a biodegradable CBD
Biodegradable cannabidiol: a potential nanotherapeutic for neuropathic pain
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Guts, Metabolism & Oral Health
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For people with nausea and/or vomiting, nabilone (a THC derivative) was prescribed after everything else had failed
Characterization of Nabilone for the Treatment of Chemotherapy-Induced and Refractory Nausea and Vomiting
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In the intestinal tissue of Crohn's disease patients, increased expression of the NAAA enzyme (and hence, the reduced levels of its substrates oleoylethanolamide & PEA) reduced intestinal scarring
P0181 Modulating macrophage activity via NAAA pharmacological inhibition: a therapeutic strategy for intestinal fibrosis
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Immune System & Microbial
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In a tissue model of tuberculosis, activating the CB2 receptor reduced proinflammatory cytokine release, the transcription of proinflammatory genes & the activation of macrophages (guardian immune cells of the brain)
Cannabinoid Receptor type 2 agonist GP1a attenuates macrophage activation induced by M. bovis-BCG by inhibiting NF-?B signaling
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Reproduction & Hormones
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During human lactation, cannabis consumption caused greater protein levels & lower fat levels in their milk
The Effect of Cannabis Consumption During Lactation on the Macronutrient Concentrations in Breast Milk
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In Quebec, a survey of how healthcare professionals communicate to pregnant people about the effects of cannabis
Talking with pregnant women exposed to cannabis use after cannabis legalization: Experiences of professionals working in Québec's social and healthcare system
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In young Queer people who recently delivered a baby, on why they were more likely to use cannabis
Exploring Peripartum Cannabis Use Among Young Sexual Minority People: A Qualitative Study
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In African-American women, interviews on their perceived neighborhood environment & cannabis use during pregnancy
Effect of Perceived Neighborhood Environment on Cannabis Use during Pregnancy among African American Women
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In pregnant & lactating dairy cows, adding omega-3 fatty acid altered their endocannabinoid system & immune responses
Omega-3 fatty acids supplementation from late pregnancy to early lactation attenuates the endocannabinoid system and immune proteome in preovulatory follicles and endometrium of Holstein dairy cows
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For prenatal cannabis exposure, using preclinical models to quantify THC fetal exposure levels
Quantification and prediction of human fetal (-)-Δ9-tetrahydrocannabinol/(±)-11-OH-Δ9-tetrahydrocannabinol exposure during pregnancy to inform fetal cannabis toxicity
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The Heart & Blood
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For Daphnia magna (a small plankton crustacean), a thesis project on the effect of CBD on heart rate
Impact of Cannabidol (CBD) on Daphnia magna Heart Rate
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The Liver & Drug Metabolism
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In liver transplant patients, therapeutic exercises increased their levels of anandamide & 2-AG
Endocannabinoid and hematological responses to pre- and post-therapeutic exercises in liver transplant patients
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In non-alcoholic steatohepatitis (serious liver disease of fatty buildup & inflammation), a mixture of olive oil & far infrared-processed hemp seed oil helped with weight gain during a choline-deficient high-fat diet
Effects of Supplementation with Far Infrared-Processed Hemp Seed Oil and Olive Oil Mixture on Choline-Deficient Diet-Induced Non-Alcoholic Steatohepatitis in Mice
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The Lungs
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On combining CBD with kaempferol (a flavonoid with medical benefits) for anti-inflammatory effects in treating chronic obstructive pulmonary disease
Kaempferol can increase aerosolization and decrease the cytotoxicity of inhaled cannabidiol
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The Skin
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In the skin, a review of the role of the eicosanoids (derivatives of arachidonic acid, the precursor to anandamide)
Metabolic pathways of eicosanoids—derivatives of arachidonic acid and their significance in skin
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Cancer & Chemotherapy
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For Australian cancer patients, a survey of their views on medical cannabis
Patients’ Perceptions of the Efficacy, Safety, and Quality of the Evidence of Medicinal Cannabis: A Survey of Australian Cancer Patients
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In cancer survivors, those who co-used cannabis & alcohol were more likely to have high blood pressure but no changes to immune biomarkers
Alcohol and Cannabis Use Associated with Cardiometabolic Biomarkers among "All of Us" Cancer Survivors
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In brain cancer cells, both CBD & AM 1172 (a drug that inhibits the FAAH enzyme as well as anandamide reuptake) sometimes combined well with treatment drugs & sometimes antagonized them
Isobolographic interactions of cannabidiol and AM 1172 with cisplatin in human neuroblastoma and glioblastoma cell lines: An in vitro study
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In colorectal cancer cells, CBD halted proliferation, migration & invasion & induced apoptosis (programmed cellular suicide) via the CB2 receptor & stress to the endoplasmic reticulum (organelle of protein modification)
P0112 Cannabidiol (CBD) targeting of colorectal cancer cells is mutation-independent and via CB2 receptor
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In leukemia cells, CBN & CBG caused anticancer effects
The Anticancer Activity of Cannabinol (CBN) and Cannabigerol (CBG) on Acute Myeloid Leukemia Cells
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In breast cancer cells, a thesis project on the combination of THC & CBD causing antineoplastic & antiproliferative effects
Identifying the cannabinoid effects against breast cancer in vitro
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In leukemia cells, CBD altered lipid levels
Unveiling cellular changes in leukaemia cell lines after cannabidiol treatment through lipidomics
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Synthetic Cannabinoids & Hemp-Derived Cannabinoids
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In Scottish prisons, on measuring the levels of the synthetic cannabinoid HHC
Detection and quantitation of the semi-synthetic cannabinoid hexahydrocannabinol in seized samples from Scottish prisons
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In adolescent mice, long-term exposure to the synthetic cannabinoid AB-FUBINACA made them more vulnerable to psychiatric disorders & in females, alterations to memory, increased anxiety, psychotic-like effects & the loss of dendritic spines (related to synaptic plasticity)
Long-term consequences of adolescent exposure to the synthetic cannabinoid AB-FUBINACA in male and female mice
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In human lymphocytes (immune cells of the bone marrow & blood), synthetic cannabinoids increased the number of sister chromatid exchanges (DNA breaking & rejoining during replication)
Synthetic Cannabinoids are Genotoxic in Cultured Human Lymphocytes
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Biochemical Discoveries & Tools
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For the CB1 receptor, a review of the structure-function relationships of its many ligands
Cannabinoid receptor 1 ligands: Biased signaling mechanisms driving functionally selective drug discovery
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On finding the negative allosteric binding site where CBD modulates the CB1 receptor
Determination of the Negative Allosteric Binding Site of Cannabidiol at the CB1 Receptor: A Combined Computational and Site-Directed Mutagenesis Study
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For the CB1 receptor, a molecular modeling comparison of phytocannabinoids versus synthetic cannabinoids [Portuguese]
Molecular modeling of cannabinoid binding to the CB1 receptor: comparing Cannabis sativa and synthetic cannabinoids
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A new fluorescent CB2 probe for imaging their location in the plasma membranes of living cells
Probing Native CB2 Receptor Mobility in Plasma Membranes of Living Cells by Fluorescence Recovery After Photobleaching
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On inhibiting the FAAH enzyme (which breaks down anandamide) with new beta-lactams
NEW b-LACTAMS TO INHIBIT THE FATTY ACID AMIDE HYDROLASE (FAAH): PREPARATION AND PHARMACOLOGICAL EVALUATION
NEW b-LACTAMS TO INHIBIT THE FATTY ACID AMIDE HYDROLASE (FAAH)
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Measuring cannabinoids in plasma using a disposable pipette extraction & UHPLC-MS/MS
A Disposable Pipette Extraction-UHPLC-MS/MS Method Based on Removal of Phospholipids to Determine Anandamide, 2-Arachidonoylglycerol, Cannabidiol, and Δ9-Tetrahydrocannabidiol in Plasma Samples
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In yeast, enhancing their biosynthesis of CBC acid
Enhancing Cannabichromenic Acid Biosynthesis in Saccharomyces cerevisiae
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On better in silico methods for computing new cannabinoid compounds
Accurate Enthalpies of Formation for Bioactive Compounds from High-Level Ab Initio Calculations with Detailed Conformational Treatment: A Case of Cannabinoids
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Thanks.
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PS: For today’s jazz saxophone, ‘African Voodoo’ by Manu Dibango, the Cameroonian sometimes called the greatest jazz saxophonist Africa ever produced. As a student & amalgamator of traditions from Afro-soul to jazz to funk to Latin music, Dibango & his group recorded the album in three days with no prior planning.
Musical from a young age, Dibango discovered jazz at 15 while attending school in France. He learned the piano & saxophone while conquering the Paris jazz scene of the ‘50s before moving to Brussels & taking up the vibraphone. He then helped to found the famous Congolese rhumba group African Jazz. He later started his own fusion group in Cameroon & worked as a studio musician in Paris. But his life changed completely when his 1972 single ‘Soul Makossa’ became an international sensation (and is now known as the most sampled African song in history). He collaborated with many of the world’s jazz greats & continued a prodigious output of music into his seventies. Awarded a UNESCO Artist for Peace award, he became an elder statesman to the musical youth of Africa up until his death from COVID in 2020.
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This newsletter is the backbone of my work & I hope it brings you a measure of value. If so, please consider upgrading to a paid subscription & support my sharing all of the new cannabinoid science each week.
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